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International Journal of
Medical Nano Research ISSN: 2378-3664

Citation

Patnaik S, Kurdekar AD, Chunduri LAA, Prathibha C, Venkataramaniah K (2018) In Vitro Dissolution Studies on Naproxen-PVP Nanoformulations Show Enhanced Oral Bioavailability of Naproxen. Int J Med Nano Res 5:023. doi.org/10.23937/2378-3664/1410023

Copyright

© 2018 Patnaik S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

RESEARCH ARTICLE | OPEN ACCESSDOI: 10.23937/2378-3664/1410023

In Vitro Dissolution Studies on Naproxen-PVP Nanoformulations Show Enhanced Oral Bioavailability of Naproxen

Sandeep Patnaik1, Aditya D Kurdekar2, LA Avinash Chunduri1, C Prathibha2 and K Venkataramaniah2*

1Andhra Pradesh Medtech Zone, India

2Laboratories for Nanoscience and Nanotechnology Research, Sri Sathya Sai Institute of Higher Learning, India

Abstract

Phase solubility behavior, physico-chemical characteristics, cytotoxicity, morphology and dissolution enhancement of Naproxen-PVP Nanoformulations have been studied. Drug-polymer ratios of 1:1, 1:2, 1:3, 1:4 for the poorly water-soluble drug, naproxen and the polymer PVP are prepared via wet milling using a conventional Retsch Planetary ball mill. The highest dissolution enhancement over that of the pure drug, 310% was achieved for the formulation ratio of 1:4. This ability of hydrophillic surfactant carriers to accelerate the in vitro dissolution of poorly water-soluble drugs has been attributed to wetting, solubilization, and/or deflocculation. The Korsmeyer-Peppas model most aptly fits the in vitro dissolution data indicating a possible drug release mechanism predominated by anomalous non-Fickian diffusion thus helping improve the physicochemical characteristics of naproxen towards its dissolution enhancement and possibly increase the oral bioavailability of the drug without any adverse cytotoxic consequences.