Regulatory Prospects of Clinical Trials with Stem Cells in the United Arab Emirates
Yandy Marx Castillo-Aleman, MD, Yendry Ventura-Carmenate, MD, Rene Antonio Rivero-Jimenez, Ph.D and Antonio Alfonso Bencomo-Hernandez, Ph.D
Article Type: Commentary | First Published: December 04, 2021
Health research and clinical trials are driving the development of valuable medical knowledge. Many types of clinical research have been conducted in the United Arab Emirates (UAE) by governmental and private health providers in recent years, and a growing number of publications and UAE-based clinical trials have been registered worldwide. However, there are wide differences between the Emirates regarding the policies governing emerging stem cell therapies. This article aims to discuss the regul...
Endogenous Soluble TRAIL Contributes to the Survival and Growth of Human Mesenchymal Stem Cells
Joaquín Marco-Brualla, Ana Gallego-Lleyda, Jara Sanz, Paula Desportes, Pablo Fernández, Luis Martínez-Lostao, Pedro Lapuente and Alberto Anel
Article Type: Original Article | First Published: March 13, 2021
TNF-related apoptosis-inducing ligand (TRAIL) is known to induce caspase-dependent apoptosis in tumor cells, while sparing normal cells. However, TRAIL is also able to induce proliferation in cells that are resistant to cell death induction, since it can also activate NF-κB-dependent signaling pathways. Human mesenchymal stem cells (hMSC) transfected with TRAIL have been used to treat cancer, with promising results in pre-clinical models, especially in gliomas. Regarding endogenous TRAIL expres...