Citation

Zittan E, Silverberg MSs (2018) Use of Dapsone for Difficult to Treat Stricturing Esophageal Crohn's Disease: A Difficult Pill to Swallow. Int Arch Clin Pharmacol 4:016. doi.org/10.23937/2572-3987.1510016

Copyright

© 2018 Zittan E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

CASE REPORT | OPEN ACCESSDOI: 10.23937/2572-3987.1510016

Use of Dapsone for Difficult to Treat Stricturing Esophageal Crohn's Disease: A Difficult Pill to Swallow

Eran Zittan* and Mark S Silverberg

Division of Gastroenterology, Mount Sinai Hospital, University of Toronto, Canada

Abstract

Crohn's disease (CD) can affect any part of the gastrointestinal tract. Although esophageal involvement is rare, it can lead to debilitating complications such as tracheobronchial fistulation. Although current guidelines recommend early, advanced therapy with acid suppression, immunosuppressants and biologics, there are a lack of specific clinical trial data demonstrating efficacy for this phenotype. Despite aggressive management, CD of the esophagus is often refractory to conventional therapy. We report a case of stricturing esophageal Crohn's disease refractory to conventional therapy that was successfully treated with endoscopic dilatation and oral dapsone.