International Archives of

Clinical PharmacologyISSN: 2572-3987

Early Online

 Open Access DOI:10.23937/2572-3987.1510027

Effect of Various Activation of the Skin TRPA1 Ion Channel on Cardiovascular Systemic Parameters in Hypertensive Rats

TV Kozyreva and ES Meyta

Article Type: Research Article | First Published: September 16, 2021

The effect of different activation of the skin TRPA1 ion channel on the parameters of the cardiovascular system was studied in rats with hereditary stress-induced hypertension while recovery from anesthesia. The activation of the TRPA1 ion channel was performed by application to skin its agonist - allyl isothiocyanate (AITC) in two concentrations 2.5% and 0.5%. The following parameters were measured that characterize the work of the cardiovascular system: Blood pressure (systolic, diastolic, and...

 Open Access DOI:10.23937/2572-3987.1510026

Analytical Validation of Quantitative Pharmacodynamic Methods used in Clinical Cancer Studies

Dick Pluim and Jos H Beijnen

Article Type: Review Article | First Published: August 20, 2021

Quantitative pharmacodynamic (PD) methods are used to assess the effect of a drug on its target. The use of these methods in clinical cancer studies has increased enormously with the advent of targeted therapies in the past years. To ensure that quantitative PD methods meet their expectations, methods need to be validated according to internationally recognized standards for amongst others specificity, accuracy, sensitivity, precision and stability. We show that 87% of our selected clinical canc...

 Open Access DOI:10.23937/2572-3987.1510025

Antimalarial Drug Prescription: Evaluation of the Healthcare Professionals based on the Malian National Malaria Control Program (NMCP) Guidelines

Karim Traoré, Seidina AS Diakité, Drissa Konaté, Sory I Diawara, Modibo Sangaré, Moussa S Maiga, Fatoumata Daou, Boubacar Fomba, Mahamadou Diakité and Sekou Bah

Article Type: Original Research | First Published: February 05, 2021

Since 2005, an artemisinin-based combination therapy has been recommended by the WHO and implemented by the National Malaria Control Program in Mali. The success of such strategy depends on the commitment of all stakeholders (patients and healthcare professionals). Therefore, it is necessary to assess the correct application of this recommendation. We carried out the analysis of the prescription of antimalarial molecules based on the NMCP’s guidelines in Kangaba and Bougouni Health Centers dur...

 Open Access DOI:10.23937/2572-3987.1510024

Antiplasmodial Activity of Ethanolic Extract of Neem Leaf (Azadirachta indica) in Albino Mice Infected with Plasmodium berghei

Afolabi Olajide Joseph, Simon-Oke Iyabo Adepeju and Oladokun Oluwatobiloba I

Article Type: Original Research | First Published: January 29, 2021

Malaria is a major public health problem in the world, particularly in the developing countries where the disease is difficult to manage due to multi-drug resistant parasites. The study aimed to evaluate the antiplasmodial activity of Azadirachta indica in the treatment of malaria disease. Fresh leaves of Azadirachta indica were air-dried at room temperature for six weeks and pulverized into powder using electric blender. Two hundred and fifty grams (250g) of the crushed powder was weighed with ...

Volume 7
Issue 1