Impact of a Dedicated Multidisciplinary Research and Treatment Network on Outcomes of Muscle-Invasive Bladder Cancer Patients
Debbie G Robbrecht, Rob HA Verhoeven, Peter de Vries, Michiel S van der Heijden, Joost L Boormans and Ronald de Wit (on behalf of the Dutch Uro-oncology Study group (DUOS))
Article Type: Original Article | First Published: February 09, 2019
Our retrospective analysis based on 3472 muscle-invasive bladder cancer patients, showed a non-significant trend towards survival benefit when treated in hospitals involved in a national study-group network (DUOS), with significantly superior outcomes concerning neo-adjuvant chemotherapy, surgical margins and lymph node dissection. These factors significantly correlated with an improved survival, favoring treatment at centers that are involved in a multidisciplinary national network with dedicated care for bladder cancer....
Exemestane-Induced Eosinophilic Colitis in a Patient with Grade 3 Ductal Carcinoma In-Situ: A Case Report and Review of the Literature
Kristyn Sanders, Shannon Lim, Sandra Ortega RN, Mark Gimbel and Lida Mina
Article Type: Case Report | First Published: February 07, 2019
Approximately after three months of exemestane therapy for breast cancer risk reduction, a 60-year-old female with estrogen receptor positive, right breast ductal carcinoma in situ (DCIS) presented to the emergency room with severe abdominal pain, nausea, vomiting, and diarrhea. Imaging studies revealed severe colitis of the transverse colon. No other medications were started except for exemestane that would have contributed to the patient's symptoms. Outpatient workup included stool cultures, laboratory studies, and esophagogastroduodenoscopy and colonoscopy with biopsies. Results of the stud...
Αβ-Crystallin and Laminin-332 are Prognostic Markers for Triple Negative Breast Cancers in a Brazilian Series
Marcia S Graudenz, Diego M Uchoa, Ermani Cadore, Juliana Giacomazzi and Sidia Maria Callegari-Jacques
Article Type: Research Article | First Published: February 01, 2019
Association between increased αβ-crystallin (ABC) and abnormal LN332 (LN332) expression in triple negative (TNBC) and basal-like (BLBC) breast cancers has been suggested recently. This study aims to evaluate ABC and LN332 immunohistochemical expression in a series of TN infiltrating ductal breast carcinomas and its association with clinical-pathological features and prognostic significance. Microarrays of 69 cases of TNBC cases were scored for the expression of ABC, LN332, CK5/6 and EGFR by immunohistochemistry with linked clinical and pathological data (age, tumor size, lymph node metastase...
High Prevalence of Hepatitis B Virus Infection among Pregnant Women Attending Antenatal Care in Central Nigeria
Peter Asaga Mac, Adamu Chipago Suleiman and Philomena Ehi Airiohuodion
Article Type: Original Research | First Published: January 30, 2019
A total of 200 pregnant women subjects were selected for this study to determine the sero-prevalence of hepatitis B virus (HBV) infection and assess the risk factors among pregnant women attending ante natal care at FMC, Keffi, Nigeria. A structured questionnaire was used for the data collection. Sera were collected and tested for hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg). The sero prevalence of HBV infection and its infectivity is high in Central Nigeria. This research article suggest the need for improved maternal health, routine immunization HBV screening among p...
Pulmonary Ultrasonography: Its Usefulness in Differentiating Pneumothorax vs. Bulla Pulmonar Gigante
Jose Luis do Pico and Miguel Angel Landa
Article Type: Image Article | First Published: January 30, 2019
A 66-year-old patient with air flow chronic obstructive who attends the emergency service due to aggravation of his usual restlessness and dyspnea. He recorded multiple admissions in the last year for the same reason, requiring mechanical ventilation and tracheotomy. It enters from the emergency service to the Critical Care Unit poorly perfused, lucid with restlessness, intermittent paroxysmal atrial tachycardia on the electrocardiogram. There is no air intake in both hemithorax. Non-invasive ventilation is attempted, failing a few minutes to try. Endotracheal intubation and mechanical ventila...
A Ghost Behind the Rectum: Extramedullary Hematopoiesis Diagnosed by Endoscopic Ultrasound Fine Needle Biopsy
Silvia Carrara, Daoud Rahal, Alessandro Fugazza, Milena Di Leo and Alessandro Repici
Article Type: Image Article | First Published: January 30, 2019
A 76-year-old woman underwent abdominal CT (Figure 1) to explore anemia and fatigue after negative results from upper and lower GI endoscopy. CT scan showed a large heterogeneous pre-sacral mass with a long axis of 60 mm. At digital rectal examination a solid mass was palpable from the posterior rectal wall. At rectal endoscopic ultrasound (EUS), the mass showed an intense hyperechoic in homogeneous echotexture, with hypovascularization and with a soft pattern at elastography (Figure 2)....
Endoscopic Vesicoureteral Reflux Treatment Outcomes in Patients with Voiding Dysfunction
Elif Altinay Kirli, Cagatay Dogan, Mehmet Hamza Gultekin, Zubeyr Talat and Bulent Onal
Article Type: Research Article | First Published: January 28, 2019
Voiding dysfunction (VD) increases the frequency of vesicoureteral reflux (VUR). Subureteric injection is an effective method for the treatment; however, the presence of VD may affect the success rates. This study evaluated the results of single-session endoscopic treatment in patients admitting with VD symptoms who were diagnosed with VUR, and the effect of compliance to VD treatment on these results. The data regarding patients who were being followed up for non-neurogenic VD diagnosis and who underwent subureteric injection or treated conservatively was reviewed retrospectively in terms of ...
Is Phoenicia the Origin of the N1303K CFTR Mutation?
Raed Farhat, Marie Claude Pasquet, Sandra Corbani, Andre Megarbane, Alain Kitzis and Veronique Ladeveze
Article Type: Commentray | First Published: January 26, 2019
The history of Lebanon, characterized by flows of different ethnic groups, has enabled the introduction of new genes and a wide variety of genetic diseases. The early development of medical services in Lebanon has facilitated the detection of many inherent disorders. CF figures among the 184 reported genetic diseases of the Lebanese population. Even though no epidemiological studies were performed to determine the CF incidence in Lebanon, multiple factors advocate that it could be relatively high....
Use of Programmed Multilevel Ventilation as a Superior Method for Lung Recruitment in Heart Surgery
Peter Candik, Adrian Kolesar, Martin Nosal, Matus Pauliny, Frantisek Sabol, Viera Donicova, Viliam Donic and Pavol Torok
Article Type: Original Article | First Published: January 26, 2019
During cardiac surgery, extracorporeal circulation (ECC) causes lung injury. In these inhomogenously affected lungs, the pressure control ventilation (PCV) cannot adequately ventilate differently damaged lung compartments. We invented and used original multilevel lung ventilation method named 3-LV based on alternating 3 or more pressure levels, ventilation frequencies and delivered tidal volumes. The goal of this article is to compare lung mechanics in cardiac surgery patient after ECC using standard PCV when compared to 3LV ventilation....