International Journal of Brain Disorders and Treatment is an international, open access, peer reviewed journal that publishes articles on causes, symptoms and diagnosis of various brain disorders, infections, trauma, stroke, seizures, and tumors of brain etc. The main objective of the journal is to disseminate the scientific work, publication, education, and exchange of ideas globally. The Journal provides authors with a platform to contribute their findings and help raise awareness among readers on brain diseases and management. We aim to provide free, immediate and unlimited access to highest quality clinical content via open access platform.

International Journal of Brain Disorders and Treatment focus on various aspects of brain disorders viz., ALS, Alzheimer's Disease, Bell's Palsy, Birth Defects of the Brain and Spinal Cord, Brain Aneurysm, Brain Injury, Brain Tumor, Cerebral Palsy, Chronic Fatigue Syndrome, Concussion, Dementia, Disk Disease of Neck and Lower Back, Dizziness, Epilepsy, Guillain-Barre Syndrome, Headache - Cluster, Headache - Tension, Migraine Headaches, Multiple Sclerosis, Muscular Dystrophy, Neuralgia, Neuromuscular and Related Diseases, Neuropathy, Parkinson's Disease, Psychiatric Conditions (Severe Depression, Obsessive-Compulsive Disorder), Scoliosis, Seizures, Spinal Cord Injury, Spinal Deformity, Spinal Disorder (Subacute Combined Degeneration), Spine Tumor, Stroke, Vertigo, etc. Original Article, Reviews, Mini Reviews, Short Communications, Case Reports, Clinical Image, Perspectives/Opinions, Letters, Short Note and Commentaries are welcome for possible publication. All articles published in the journal are subject to a rigorous peer review process.

 
Journal Information

Title: International Journal of Brain Disorders and Treatment

ISSN: 2469-5866

Editor-in-chief: Terry Lichtor

NLM title abbreviation: Int J Brain Disord Treat

ISO abbreviation: Int J Brain Disord Treat

Other titles: IJBDT

Category: Neuroscience

Country of publication: USA

Language: English

DOI: 10.23937/2469-5866

Publication format (s): Electronic and print

Publication policy: Open Access; COPE guide

Peer review: Double blind

Review speed: 3 weeks

Fast-track review: 10 days

Publication type(s): Periodicals

Publisher: ClinMed International Library

Contact email: contact@clinmedjournals.org

 
Articles Search by   Keyword   |   Journal title   |   Author name   |   DOI

 

 Open Access DOI:10.23937/2469-5866/1510023

Case Report: Paired/Dual Colloid Cysts in the Third Ventricle - A Discussion of Embryological Origin

SM Jay and MR MacFarlane

Article Type: Case Report | First Published: May 25, 2018

A 31-year-old male presented with a 4-month history of rising intracranial pressure. Initial computed tomography (CT) and then magnetic resonance imaging (MRI) showed moderate dilatation of the lateral ventricles with periventricular signal change, an indistinct third ventricle with an ill-defined lesion in the anterosuperior part of the third ventricle. At time of operation two paired/dual colloid cysts were found lying side-by-side in the third...
 

 Open Access DOI:10.23937/2469-5866/1510022

Concomitant Behavioral, Electrochemical and Electrophysiological Study in Real Time on the Role of CRF and CRF Antagonist(S) in Anxiety and Depression: Possible Association CRF + 5-HT Receptor Antagonists?

Francesco Crespi

Article Type: Research Proposal | First Published: February 08, 2018

Corticotropin releasing factor (CRF) is involved in conditions of anxiety and stress: It stimulates the release of adrenocorticotropin hormone (ACTH). Also, catecholamines increase ACTH release, while serotonin (5-HT) increases both ACTH and CRF. ...
 

 Open Access DOI:10.23937/2469-5866/1510021

The Effect of a Functional Intensive Intervention Program on Self-Care in Children with Cerebral Palsy: A Case Study

Rosanne Roelofsma and Eugene Rameckers

Article Type: Original Research | First Published: November 29, 2017

Former studies have shown that usual care in children with Cerebral Palsy (CP) often lacks effectiveness. Task-oriented functional intensive therapies have been shown to be promising for CP patients. The present case study aimed to examine the effect of a task-oriented functional intensive therapy program....
 

 Open Access DOI:10.23937/2469-5866/1510020

Specific Effects of Antipsychotic Chlorpromazine on Glutamatergic Ionotropic Mechanisms. Novel Targets for Treatment Schizophrenia

Anatoly A Mokrushin

Article Type: Research Article | First Published: October 25, 2017

Chlorpromazine hydrochloride (CPZ) refers to antipsychotic drugs. CPZ is drug of first choice for the treatment of schizophrenia. However, its impact on the main excitatory neurotransmitter system, glutamatergic, is unclear. This issue is the aim of our study....
 

 Open Access DOI:10.23937/2469-5866/1510019

Microglial NLRP3 Activity in Alzheimer's Disease

Bruno Cabral de Lima Oliveira

Article Type: Review Article | First Published: September 11, 2017

Alzheimer's Disease (AD) is the major disease leading to dementia. This disease is characterized by the presence of β-Amyloid (Aβ) extracellular deposits and neurofibrillary tangles, which induce senile plaques formation. Furthermore, inflammation in AD is mainly mediated by innate immunity-related cells, especially microglia....
 

 Open Access DOI:10.23937/2469-5866/1510018

Evaluation of Seizures in Patients with Chronic Subdural Hematoma Treated by Burr-Hole Surgery and Risk Factors for Seizures

Tetsuhisa Yamada and Yoshihiro Natori

Article Type: Research Article | First Published: March 27, 2017

Chronic subdural hematoma is one of the most commonly encountered diseases in neurosurgery. The treatment method is well established, but seizures develop as a complication in 2.3% to 20.4% of patients. We studied patients with seizures to clarify the status of patients at the onset of seizures and define risk factors for seizures....
 

 Open Access DOI:10.23937/2469-5866/1510017

Headache Attributed to Obsessive Compulsive Disorder of Mastication

Mianwang He, Xiaolin Wang and Shengyuan Yu

Article Type: Editorial Letter | First Published: December 23, 2016

A 51-years-old man who had developed severe phobia, anxiety since took illicit drugs twice 10 years ago, subsequently palpitation and shortness of breath appeared, having a continuous feeling that someone would attack him and he would die soon. Only mastication can partially relieve phobia and anxiety, and continuous involuntary mastication habit with left side teeth was developed. Anxiety and depression diagnosis was made by local clinic, but he...
 

 Open Access DOI:10.23937/2469-5866/1510016

Meta-analysis of Association between Helicobacter pylori Infection and Epilepsy

Gang Yao, Ping Wang, Xiang-Dan Luo and Ting-Min Yu

Article Type: Original Article | First Published: December 06, 2016

Despite recent research focus on the association between Helicobacter pylori (H. pylori) infection and epilepsy there is no consensus about the findings. To obtain a more comprehensive estimate of the association we conducted a meta-analysis to determine the prevalence of H. pylori infection in epilepsy patients and healthy controls. PubMed, EMBASE, Cochrane Library, Web of Science, Google Scholar and CINAHL were searched to identify eligible stu...
 

 Open Access DOI:10.23937/2469-5866/1510015

Hyperintentionality Hypothesis of Major Depression. Disordered Emotional and Cognitive Self-Observation in Tripartite Synapses and the Glial Networks

Bernhard J Mitterauer

Article Type: Original Article | First Published: December 03, 2016

Major depressive disorder is basically a disorder of the integration of distinct time periods generated in tripartite synapses and the astroglial networks. If the sequence of time periods is dysregulated, the patient does not only suffer from emotional impairment but also from cognitive deficits dependent on the brain region affected. Since the synaptic interactions operate on feedforward and feedback mechanisms, I speak of synaptic locations of ...
 

 Open Access DOI:10.23937/2469-5866/1510014

Predictive Factors of Brain Death in Acute Neurocritical Patients Identified as Potential Organ Donors

Guixing Xu, Ping Xu, Jing Zhao, Zhiyong Guo and Xiaoshun He

Article Type: Prospective Observational Study | First Published: August 25, 2016

In this prospective observational study, we collected clinical data of acute neurocritical patients with a potential progression to BD, who was admitted in the First Affiliated Hospital of Sun Yet-sen University from May 2015 to April 2016. Final endpoint was adjudicated brain death (BD). The clinical data were compared between patients who identified as BD within 7 days and those who identified beyond 7 days, the time of spontaneous respiratory ...
 

 Open Access DOI:10.23937/2469-5866/1510013

Maternal Undernutrition in Rats Affects Hippocampal Development through Inhibition of Neurogenin 1

Marquis L Jessie, Lili C Kudo, Nancy Vi, Kimbley Lau, Mina Desai, Michael G Ross and Stanislav L Karsten

Article Type: Research Article | First Published: July 11, 2016

Maternal undernutrition (UN) in rats inhibits neurologic development in offspring. To investigate these alterations we compared hippocampal global gene expression profiles of UN and control newborn pups. Whole transcriptome microarray analysis revealed significant changes in the expression of several genes including Neurogenin1 (Ngn1), a known neuro developmental regulatory factor. Expression of Ngn1 in the UN hippocampus was nearly 70% reduced. ...
 

 Open Access DOI:10.23937/2469-5866/1510012

Decreased Hippocampal Volume is Related to White Matter Abnormalities in Treatment-Resistant Depression

Christina B Young, Philip van Eijndhoven, Robin Nusslock, Guillen Fernandez, Aart Schene, Christian F Beckmann and Indira Tendolkar

Article Type: Original Article | First Published: June 22, 2016

Despite considerable research on the pathophysiology of unipolar depression, relationships between gray and white matter brain changes associated with treatment-resistant depression (TRD) have been sparsely investigated. Here, we used voxel-based morphometry and tract-based spatial statistics to examine differences in fronto-limbic gray matter volume and their connecting white matter tracts, respectively....
 

 Open Access DOI:10.23937/2469-5866/1510011

Executive Dysfunction and Processing Speed Predict Nonverbal Problem Solving Deficits in a Substance Use Disorder Population

Gerald T Voelbel, Zijin Wu, Cristina Tortarolo and Marsha E Bates

Article Type: Empirical Research | First Published: May 26, 2016

Individuals with chronic substance use disorders have demonstrated various types of executive dysfunction, including nonverbal planning and problem solving. Prior studies that have examined the cognitive abilities that support performance of the Tower of Hanoi, a measure of nonverbal planning and problem solving task, have predominately been investigated in healthy adult populations. The present study examined how executive functions such as conc...
 

 Open Access DOI:10.23937/2469-5866/1510010

Congenital Marin-Amat Syndrome and Asymmetric Crying Face: A Case Report

Arzu Ekici, Kursat Bora Carman, Ozlem Ozdemir, Aynur Kucukcongar and Mehmet Ali Ekici

Article Type: Case Report | First Published: March 18, 2016

Marin-Amat syndrome is a rare facial synkinesis and is characterized by the eyelid drooping on jaw opening. It is mostly an acquired phenomenon occurring after peripheral facial paralysis and very rarely congenital. Asymmetrical crying face is a rare minor congenital anomaly, that is the result of unilateral agenesis or hypoplasia of the depressor anguli oris muscle. Our case is the second one in which the onset of Marin-Amat Syndrome is congenit...
 

 Open Access DOI:10.23937/2469-5866/1510009

Diagnostic Challenge of Ovarian Teratoma Related Anti N-Methyl-D-Aspartate Receptor Encephalitis in a Patient with Giant Arachnoid Cyst

Kilinc O, Gulatar B, Gonul O, Yildizhan B and Midi I

Article Type: Case Report | First Published: January 26, 2016

Anti-N-methyl-D-aspartate receptor (NMDAr) encephalitis is well-characterized and treatable subtype of inflammatory encephalitis. This type of encephalitis is often associated with ovarian teratoma in young women and characterized by memory deficits, seizures, confusion and psychological disturbances. In this report, we presented a case of anti-NMDAr encephalitis in a woman with a previously asymptomatic, giant posterior fossa arachnoid cyst (AC)...
 

 Open Access DOI:10.23937/2469-5866/1510008

Pathological Changes of Astrocytes under Seizure

Shanshan Lu, Fushun Wang and Jason H. Huang

Article Type: Review Article | First Published: January 09, 2016

Multiple lines of studies support the view that defective functions of astrocytes contribute to neuronal hyper-excitability in the epileptic brain. Autopsy and surgical resection specimens find that post-traumatic seizures and chronic temporal lobe epilepsy may originate from glial scars. Astrogliosis, a component of glial scar, which involves structural and metabolic changes in astrocytes, is often a prominent feature of temporal epilepsy and mo...
 

 Open Access DOI:10.23937/2469-5866/1510007

Speech Disorder and Behavioral Involvement in a Thalamic Stroke: A Case Report

Paola Caruso, Moretti R and Manganotti P

Article Type: Case Report | First Published: December 14, 2015

Data from literature on clinical manifestation of thalamic strokes have been published for ages. First in 1906 Dejerine e Roussy has spoken about sensory motor disturbances and have opened the door to new pathologic disorders that may occur after thalamic lesions. From 1925 behavior and speech disorders related with thalamic injury were described. Since then a classification of thalamic syndromes into four groups based on the four main arterial t...
 

 Open Access DOI:10.23937/2469-5866/1510006

Subarachnoid Haemorrhage in Patient with Eosinophilic Granulomatosis with Polyangiitis (Churg and Strauss): A Probable Central Nervous Localisation of Vasculitis

Lescuyer Sylvain, Rondeau-Lutz Murielle, Martinez Camille, Rakotoarivelo Hanta-Nirina and Weber Jean-Christophe

Article Type: Case Report | First Published: October 22, 2015

We report the case of a 43 year-old patient with Subarachnoid haemorrhage (SAH). He was diagnosed with EGPA because of asthma, naso-sinusal polyposis, asymmetrical peroneal neuritis, general signs, eosinophilic count at 4000/mm3, CRP at 50 mg/l and positive pANCA with anti-MPO specificity at 74 U/ml. Arteriography was normal. He was treated by methylprednisolone and cyclophosphamide. Remission was complete. EGPA is a rare primary vasculitis. Only...
 

 Open Access DOI:10.23937/2469-5866/1510005

Guillain-Barre Syndrome with Lymphocytic Pleocytosis of the CSF

Sneha Padidam, Jacqueline Kraft and M Kamran Athar

Article Type: Case Report | First Published: October 8, 2015

60-year-old man presented with progressive lower-extremity weakness that progressed to involve respiratory failure and are flexia over several weeks. Electromyography showed both demyelinating and axonal features. Lumbar puncture revealed a lymphocytic pleocytosis. Given the abnormalities on these tests with a clinical picture of Guillain-Barre the patient underwent extensive paraneoplastic testing and full neuro-axis imaging. Imaging revealed ab...
 

 Open Access DOI:10.23937/2469-5866/1510004

Cranial Electrotherapy Stimulation (CES) in Neuropsychiatry: Definition & Insights from Electric Learning Paradigms

Naisberg Yakov

Article Type: Research Article | First Published: September 10, 2015

The main point here is that CES method employ at both practices systematic applications of non-invasive, harmless electric currents in the range of 50 micro-to 2 milliamper, varying from 10 Hz to 100 kHz frequencies. They inject from 10 ms to 250 ms by each scalp pair out of an array of EEG electrodes transporting to regions of interest. Such electromagnetic forces induce equivalent number of ionic oscillatory streams crossing the brain in calibr...
 

 Open Access DOI:10.23937/2469-5866/1510003

Benefits of Temporary Intrathecal Baclofen Therapy: Management of Tone and Spasticity

Melissa Ann Eppinger, Thomas J. Sernas and Catherine Anne Mazzola

Article Type: Case Series | First Published: September 9, 2015

Spasticity and dystonia may develop as a consequence of brain or spinal cord injury (SCI). Central nervous system (CNS) injury may be permanent or temporary, depending on the etiology of brain or spinal cord injury. In anoxic brain injury, there may be transient or reactive demyelination due to cell death or cell dysfunction. If there is ischemia without true infarction, or cell death, there may be some ability of the brain to repair itself or re...
 

 Open Access DOI:10.23937/2469-5866/1510002

MicroRNA in Brain Neoplasia: A Review

Michela Visani, Giorgia Acquaviva, Gianluca Marucci, Moira Ragazzi, Enrico Fraceschi, Alba A Brandes, Giovanni Tallini, Annalisa Pession and Dario de Biase

Article Type: Review Article | First Published: August 27, 2015

MicroRNAs (miRNAs) are small RNAs involved in regulation of several cellular processes and are involved in the silencing of cell's message in a variety of ways. In cancer, miRNAs can be involved in the regulation of important genes involved in tumorigenesis, tumor development, and angiogenesis. For these reasons, miRNAs could have considered oncogenic-miR (miRNA with oncogenic roles) or oncosuppressor-miR (miRNA with tumor suppressor roles). MiRN...
 

 Open Access DOI:10.23937/2469-5866/1510001

External Carotid Artery Steal Syndrome via Occipital-Vertebral Anastomosis

Menarvia Nixon, Anil Nanda and Hugo Cuellar-Saenz

Article Type: Case Report | First Published: August 26, 2015

We describe a case of ECA steal syndrome due to occipital- vertebral anastamosis in an 81 y/o female patient who presented with gait ataxia and dizziness. She was referred to Neuro-interventional Radiology after discovery of carotid bruits on her physical examination. A digital subtraction angiogram confirmed mild internal carotid artery stenosis, however, more concerning was the discovery of retrograde flow of the right vertebral artery with fil...

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