SARS-Cov-2 Neurological Infection: Implications and Possible Mechanisms
Marco Antônio Machado Schlindwein, Letícia Caroline Breis, Isabelle Pastor Bandeira and Marcus Vinicius Magno Gonçalves, MD, PhD
Article Type: Commentary | First Published: April 16, 2020
COVID-19 is an emergent disease with reported neurotropism and neuroinvasion, although its pathophysiology is not yet understood. We present the newly discoveries and hypothesis for SARS-Cov-2 neurological infection. Recently, the first case of encephalopathy associated with SARS-COV2 infection described was published. The patient rapidly progressed from fever and cough to an altered mental status, headache and unresponsive to verbal commands, with no alterations in the liquor, suggesting that t...
Late-Life Alzheimer's Disease (AD) Detection Using Pruned Decision Trees
Gopi Battineni, Nalini Chintalapudi and Francesco Amenta
Article Type: Original Research | First Published: February 08, 2020
Machine Learning (ML) is a contemporary technique of artificial intelligence. These methods are exponentially rising in the medical field, especially in diagnosis and disease predictions. The present study was aimed to develop a decision tree model to predict late-life Alzheimer’s disease (AD). A dataset of 150 subjects along with 373 MRI sessions demographic values were considered in this paper. Pruned decision trees (J48) were employed to do predictive analysis on AD subjects. Model validati...
Assessment of the Topographic Memory in Epileptic Patients
BAKOU Niangoran Francois, KPI-N'DIH Annabelle, BA Abdoulaye and ADOU Kobenan Fieni
Article Type: Research Article | First Published: December 04, 2019
The method used is that of named Route Learning Task (RLT). It is a path learning task (topographic memory) that is based solely on learning a route composed of visual but non-verbal cues so that there is no influence of Examiner language or signposts on patient behavior. At a normal walking pace, the subjects had to travel a 10-minute loop in the cocody university hospital. The route (approximately 200 m) included 7 crossings that required an orientation decision. The examiner showed the route ...
Optic Perineuritis Secondary to Sjogreen’s Syndrome: Case Report
Juliana Emy Tolachinski Oikawa, Julia Gomes Leite de Souza, Vitoria Caroline Cardoso Ferreira, Paulo Roberto Wille, MD, PhD, Laura Fiuza Parolin, MD and Marcus Vinícius Magno Goncalves, MD, PhD
Article Type: Case Report | First Published: November 04, 2019
Optic perineuritis (OPN) is a rare inflammatory disease involving the optic nerve sheath, causing pain and disc edema and is often bilateral. The diagnosis of OPN is commonly based on magnetic resonance imaging (MRI) findings and clinical features. In MRI it is possible to visualize a circumferential enhancement around the intraorbital optic nerve with preservation of the nerve itself (doughnut sign). This is better seen in contrast-enhanced and suppressed coronal MRI sequences with fat. Magneti...
Interleukin 31 and Mast Cells: A New Piece in the Puzzle of the Pathophysiology of Multiple Sclerosis?
Andre Eduardo de Almeida Franzoi, Marcus Vinicius Magno Goncalves, Osvaldo Nascimento and Jefferson Becker
Article Type: Short Commentary | First Published: November 30, 2018
During development, they enter the brain by way of penetrating blood vessels, with which they remain associated. MCs can move through the blood-brain barrier (BBB) of normal brain, but may also traverse the blood-spinal cord barrier and BBB when compromised by disease. They are capable of phagocytosis, antigen presentation, and can also modulate the adaptive immune response....
Neuregulin in Health and Disease
Juan Carlos Cespedes, Mingli Liu, Adriana Harbuzariu, Annette Nti, John Onyekaba, Hanna Watson Cespedes, Praveen K Bharti, Wesley Solomon, Precious Anyaoha, Sri Krishna, Andrew Adjei, Felix Botchway, Byron Ford and Jonathan K Stiles
Article Type: Review Article | First Published: November 10, 2018
Neuregulins, a family of EGF-like signaling molecules, are involved in cell-cell crosstalk and play an important role in development, maintenance and repair of the nervous system, heart, breast and other organs. Independent studies described a ligand for the oncogene ErbB2 (neu, Her2) and factors that stimulated proliferation of Schwann cells, as well as synthesis of receptors for acetylcholine by muscle. These ligands and factors are essentially products of the same gene, referred to by Marchio...
Case Report: Paired/Dual Colloid Cysts in the Third Ventricle - A Discussion of Embryological Origin
SM Jay and MR MacFarlane
Article Type: Case Report | First Published: May 25, 2018
A 31-year-old male presented with a 4-month history of rising intracranial pressure. Initial computed tomography (CT) and then magnetic resonance imaging (MRI) showed moderate dilatation of the lateral ventricles with periventricular signal change, an indistinct third ventricle with an ill-defined lesion in the anterosuperior part of the third ventricle. At time of operation two paired/dual colloid cysts were found lying side-by-side in the third ventricle and obstructing both foramena of Munro....