Journal of Rheumatic Diseases and Treatment (JRDT) is an international peer-reviewed journal committed to promoting the best standards of scientific discoveries and education. It covers all aspects of medical specialty, which has the spectrum of musculoskeletal conditions, arthritic disease, and connective tissue disorders. JRDT publishes basic, clinical, and translational research.

Journal of Rheumatic Diseases and Treatment is a newly launched journal which provides elaborate author benefits along with reliable copy rights policy. We are open to invite experts to join our editorial board of JRDT. All the articles pass through a dual review process in which two independent review comments followed by editor's decision will be considered to publish the article. JRDT ensures the maintenance of its standards by publishing the high quality, original and new advances in its field.

 
Journal Information

Title: Journal of Rheumatic Diseases and Treatment

ISSN: 2469-5726

Editor-in-chief: Bruce M. Rothschild

NLM title abbreviation: J Rheum Dis Treat

ISO abbreviation: J Rheum Dis Treat

Other titles: JRDT

Category: Rheumatology/Orthopedics/Musculoskeletal diseases

Country of publication: USA

Language: English

DOI: 10.23937/2469-5726

Publication format (s): Electronic and print

Publication policy: Open Access; COPE guide

Peer review: Double blind

Review speed: 3 weeks

Fast-track review: 10 days

Publication type(s): Periodicals

Publisher: ClinMed International Library

Contact email: contact@clinmedjournals.org

 
Articles Search by   Keyword   |   Journal title   |   Author name   |   DOI

 

 Open Access DOI:10.23937/2469-5726/1510065

Monitoring the Time Course of Disability through a Self-Assessment Instrument "Activity Index" (IA) in RA Patients

L Ren, X Zhang, ZG Li, H Tang and R Theiler

Article Type: ORIGINAL RESEARCH | First Published: September 01, 2018

Rheumatoid arthritis (RA) is a heterogeneous autoimmune disease whose etiopathogenesis is largely unknown. Available treatments, though effective, are insufficient in so far as there is no cure for a major proportion of patients. In those patients the disease becomes chronic with progressive joint damage, disability, and limitation of participation. Current treatment approaches include pain-relieving drugs and anti-inflammatory medications that slow joint damage, combined with physical therapies...
 

 Open Access DOI:10.23937/2469-5726/1510064

Trend of Frequency and Outcome of Reactive Arthritis in Japanese Patients with Bladder Cancer following Intravesical BCG Therapy over the Last 20 Years

Yoshinori Taniguchi, Hirofumi Nishikawa, Yasuhiko Yoshinaga, Eri Amano, Shigeto Kobayashi and Yoshio Terada

Article Type: Brief Report | First Published: June 23, 2018

Reactive arthritis (ReA) is a sterile arthritis occurring in a genetically predisposed individual, secondary to an extra-articular infection, usually of the gastrointestinal or genitourinary tract. Intravesical instillation of Bacillus Calmette-Guerin (iBCG) is used as an effective immunotherapy of bladder cancer. Despite of the clinical efficacy, ReA could develop as adverse event and the frequencies are known as about 0.5 to 1% in Western countries and 2.0% in Japan. However, the trend of freq...
 

 Open Access DOI:10.23937/2469-5726/1510063

Multifocal Avascular Necrosis of the Lunate and Triquetrum in a Child with Systemic Lupus Erythematosus

Roberts DC, Jester A, Southwood T, Johnson K and Oestreich K

Article Type: Case Report | First Published: June 15, 2018

Avascular necrosis is a known complication of systemic lupus erythematosus. We report an unusual case of avascular necrosis affecting both the lunate and triquetrum in a child with this condition. Vasculitis, synovitis and IgM anticardiolipin antibodies were probable predisposing factors. The use of arthroscopic synovial debridement improves symptoms even in the presence of carpal chondromalacia and potentially delays the need for salvage surgery...
 

 Open Access DOI:10.23937/2469-5726/1510062

Autoimmunity and Lymphoma: A Brief Review

Edward B Miller

Article Type: Review Article | First Published: June 15, 2018

The relationship between the immune system and both Hodgkin's (HL) and Non-Hodgkin's (NHL) lymphomas is a complex bidirectional process which has fascinated researchers and clinicians for many years. Lymphomas of all types are known to be associated with autoimmune paraneoplastic manifestations, and conversely are recognized in increased frequency in patients with pre-existing autoimmune diseases....
 

 Open Access DOI:10.23937/2469-5726/1510061

Ten Year Risk of Cardiovascular Events during anti-TNF Alpha in Rheumatoid Arthritis Patients

Ilaria Cavazzana, Carlo Alberto Scire, Francesca Dallara, Maria Lorenza Muiesan, Angela Tincani and Franco Franceschini

Article Type: Research Article | First Published: June 14, 2018

Rheumatoid arthritis (RA) is a chronic and systemic inflammatory disease, characterized by an increased risk of premature death, largely due to cardiovascular disease (CVD) and particularly to coronary artery disease (CAD). In addition to classical Framingham CV risk factors, the inflammatory burden of the disease leads to the development of early and accelerated atherosclerosis, mediated by cytokines, immune complex, abnormal lipid metabolism and endothelial dysfunction....
 

 Open Access DOI:10.23937/2469-5726/1510060

Modulation of Histone Deacetylases (HDACs) Expression in Patients with and without Systemic Lupus Erythematosus: Possible Drug Targets for Treatment

Kenneth L Wiley, Edward Treadwell, Kayihura Manigaba, Beverly Word, Jarren Oates and Beverly D Lyn-Cook

Article Type: Research Article | First Published: April 28, 2018

There is increasing evidence that epigenetic factors may play a role in the pathogenesis of Systemic Lupus Erythematosus (SLE). Both global and gene specific methylation is known to occur in lupus patients, as well as, changes in histone acetylation status. Histone acetylation is associated with active chromatin or activation of genes, whereas histone deacetylase (HDAC) activity is associated with silencing of genes. Therefore, HDACs have been ta...
 

 Open Access DOI:10.23937/2469-5726/1510059

Synovial Macrophages: Potential Key Modulators of Cartilage Damage, Osteophyte Formation and Pain in Knee Osteoarthritis

Majoska HM Berkelaar, Nicoline M Korthagen, Gerrit Jansen and Willem Evert van Spil

Article Type: Review Article | First Published: March 03, 2018

Synovitis is common in knee OA patients and a known contributor to disease incidence and progression. Macrophages are the most common immune cell type present in this inflamed synovial tissue and expectedly contribute both directly and indirectly to OA progression through the induction of inflammatory mediators, growth factors and proteinases, resulting in enhanced cartilage degeneration and osteophyte formation. Furthermore, macrophage infiltrat...
 

 Open Access DOI:10.23937/2469-5726/1510058

The Role of Interleukin-37 in Inflammation: Suppression or Promotion?

Liping Ding, Xiaoping Hong and Dongzhou Liu

Article Type: Mini Review | First Published: January 22, 2018

IL-37 not only has anti-inflammatory effects, but also induces marked metabolic changes with higher levels of muscle AMPK, greater rates of oxygen consumption, and increased oxidative phosphorylation both in the context of inflammation- induced fatigue and in healthy mice. In addition, expression of human IL-37 in mice could protect cardiomyocytes from apoptosis and suppress the migration ability of neutrophils in myocardial ischaemia/reperfusion injury condition....
 

 Open Access DOI:10.23937/2469-5726/1510057

Rheumatoid Pulmonary Nodules and Significantly Elevated Urinary Cadmium in a Kaolin (China Clay) Worker: Could Cadmium Adsorption onto Occupationally Inhaled Dust Explain Caplan's Syndrome?

Dan Murphy, Robert Marshall, Chris Harrington, Andrew Taylor and David Hutchinson

Article Type: Case Report | First Published: November 10, 2017

Over 60 years ago Caplan's syndrome was described in the coal miners of South Wales (UK). Higher rates are seen in mining populations globally, particularly in kaolin workers. We describe Caplan's syndrome in a kaolin worker associated with a raised urinary cadmium level....
 

 Open Access DOI:10.23937/2469-5726/1510056

Relationship between Serum 25-Hydroxyvitamin D Levels, Disease Activity and Anti-Cyclic Citrullinated Peptide Antibody Levels in Indian Rheumatoid Arthritis Patients

Shradha C Borukar, Arun R Chogle and Sudha S Deo

Article Type: Research Article | First Published: September 29, 2017

In our study, 42 RA patients were selected according to the ACR Criteria and 50 healthy participants were recruited for comparison, as controls. After a detailed medical history and anthropometric evaluation, all participants were subjected to CRP analysis and their disease activity scores (DAS28-CRP) were calculated using DAS calculator....
 

 Open Access DOI:10.23937/2469-5726/1510055

Clinical and Ultrasonic Characteristics of 100 New Crystal Proven Gouty Patients in a Rheumatology Clinic

Ole Slot

Article Type: Research Article | First Published: September 29, 2017

A 30-years old study reported gout to be oligo- or polyarticular in 40% of cases presenting to a rheumatology clinic. The prevalence of gout has increased markedly since and presently gout has become the most prevalent inflammatory joint disease. Furthermore, specific Ultrasound (US) changes in gout have been described in recent years....
 

 Open Access DOI:10.23937/2469-5726/1510054

Sustainability and Clinical Effectiveness of Inpatient Rehabilitation in Painful Shoulder Diseases

Werner Kullich, Barbara Stritzinger, Monika Mustak-Blagusz, Thomas Berger, Albrecht Falkenbach4 Jutta Rus-Machan and Bibiane Steinecker-Frohnwieser

Article Type: Research Article | First Published: September 01, 2017

Complaints of the shoulder are often accompanied with pain, function lease and impaired quality of life. Inpatient rehabilitation in Austria acts as a powerful non-operative intervention to improve shoulder function and to reduce pain. The aim of this presented study was to observe the long-lasting effects of rehabilitation on shoulder complaints in a follow up trial....
 

 Open Access DOI:10.23937/2469-5726/1510053

Algorithm for Treatment of Hip and Knee Osteonecrosis: Review and a Presentation of Three Example Cases

Kim-Orden Michael, Barrett Kody and Khatod Monti

Article Type: Case Series | First Published: July 19, 2017

Osteonecrosis (ON) of the hip and knee can be a source of severe morbidity for affected individuals. Although several risk factors and explanations for the pathogenesis of ON have been recognized, there exists little consensus in the literature as to the appropriate clinical management....
 

 Open Access DOI:10.23937/2469-5726/1510052

Rheumatoid Arthritis of the Craniovertebral Junction: Surgical Strategies, Current Approach and Proposal of a New Therapeutic Algorithm

Luis Eduardo Carelli Teixeira da Silva, Alderico Girao Campos de Barros and Marcelo Glauber da Silva Pereira

Article Type: Review Article | First Published: June 12, 2017

Rheumatoid Arthritis (RA) is a systemic inflammatory disease with an autoimmune feature and an etiology that is still unknown. It is characterized by a symmetrical peripheral polyarthritis that affects primarily the small joints of hands and feet, with several levels of extra-articular manifestation....
 

 Open Access DOI:10.23937/2469-5726/1510051

A Pediatric Case of NMOSD with Positive Seroconversion of AQP4-ab after 5 Years and Subsequent Diagnosis of SLE

Aisha Bushra, Osman Farooq, Svetlana P Eckert, Caila B Vaughn, Rabheh Abdul Aziz and Bianca Weinstock-Guttman

Article Type: Case Report | First Published: March 18, 2017

Neuromyelitis optica spectrum disorder (NMOSD) is a demyelinating disorder of the central nervous system that is distinct from multiple sclerosis and is primarily characterized by recurrent episodes of optic neuritis (ON) and/or longitudinal extensive transverse myelitis (LETM). The presence of aquaporin antibodies (AQP4-ab) in the serum and/or cerebrospinal fluid (CSF) is a highly specific biomarker for diagnosis, although repeated testing may b...
 

 Open Access DOI:10.23937/2469-5726/1510050

Role of Strontium Ranelate in the Therapy of Osteoporosis

Pavel Horak, Martina Skacelova and Ahmed Kazi

Article Type: Review Article | First Published: March 01, 2017

Strontium ranelate is a medicine used to treat postmenopausal osteoporosis in women and osteoporosis in men. Preclinical data suggest its dual effect consisting of the control of bone resorption and promotion of bone formation. Administration of strontium ranelate leads to significant increase in the bone mass. Changes in bone density can be used to evaluate the adherence of patients as well as, in case of strontium ranelate, to estimate the frac...
 

 Open Access DOI:10.23937/2469-5726/1510049

Rheumatic Disease Frequency in Hospitilized Acute Stroke Patients

Nihal Ozaras, M Serdar Sag, M Akif Sariyildiz and Sule Deveci

Article Type: Letter to the Editor | First Published: February 21, 2017

Rheumatic diseases (RD) have increased risk for stroke. We examined the records of acute stroke patients for concomitant diseases. Two of 178 patients had gout, no other RD was detected. Considering the result of our study and current evidence in the literature, we suggest that patients with gout should be monitored closely for the risk of stroke and the clinician should be aware of higher risk of stroke in these patients....
 

 Open Access DOI:10.23937/2469-5726/1510048

SLE - Update Ethiopathogenesis Leading to Biological Therapy

J Rovensky, S Blazickova and I Stiborova

Article Type: Review Article | First Published: February 21, 2017

Systemic lupus erythematosus is a chronic, autoimmune disorder which may have even fatal consequences, particularly if it affects vital organs of the human body. It is typically manifested by inflammation of various organ systems. The course of the disease includes sporadic flare-ups, or relapses, which may lead to irreversible damage of the organs. The focus is on the suppression of clinical symptoms, inhibition of the formation of autoantibodie...
 

 Open Access DOI:10.23937/2469-5726/1510047

Glucocorticoid-Induced Leucine Zipper (Gilz) in Rheumatoid Arthritis: Relationship with Disease Activity and Steroid Use

Laura E Eades, Angeline S Thiagarajah, Sarah A Jones, Huapeng Fan, Anastasios Nalpantidis, Eric F Morand and Michelle Leech

Article Type: Research Article | First Published: February 21, 2017

Clinical data was obtained from RA patients and medical records. Three control cohorts were also recruited, including 23 healthy controls, 25 patients with fibromyalgia and 44 patients with depression. Blood was taken from each participant. Following isolation of peripheral blood mononuclear cells (PBMC) from whole blood, RNA was extracted. Reverse transcription polymerase chain reaction (RT PCR) and quantitative real time PCR (qPCR) were perform...
 

 Open Access DOI:10.23937/2469-5726/1510046

Scleroderma Renal Crisis

Gioacchino Li Cavoli, Luisa Bono, Calogera Tortorici, Carlo Giammarresi, Tancredi Vincenzo Li Cavoli and Ugo Rotolo

Article Type: Case Report | First Published: February 14, 2017

Scleroderma or Systemic sclerosis is a vascular and fibrotic disease with organ-based complications and high mortality and morbidity. Renal involvement can be quite varied and scleroderma renal crisis is the most severe manifestation. We report our experience. In February 2016 a 52-year-old male was admitted to hospital with pulmonary oedema and severe arterial hypertension (240/120 mmHg)....
 

 Open Access DOI:10.23937/2469-5726/1510045

Relapsing Polychondritis with Central Nervous System Involvement Presented as Encephalitis: 7 Cases and Literature Review

Anna Zhou, Xindi Li, Lin Zhao, Yonghong Liu and Xinghu Zhang

Article Type: Research Article | First Published: February 13, 2017

Objectives: This study aims to describe the clinical manifests, CSF features and brain MRI characters of patients with relapsing polychondritis (RP) and central nervous system (CNS) involvement presented as encephalitis. Methods: Seven cases with RP and CNS involvement were enrolled from 2011 to 2015. RP was diagnosed upon the modified McAdam criteria, and CNS dysfunction secondary to RP was decided by clinical manifests, CSF analysis and brain M...
 

 Open Access DOI:10.23937/2469-5726/1510044

Is There a Correlation Between DAS28/RADAI in a Cohort of Rheumatoid Arthritis Patients Treated with Biological Therapy

Hèctor Corominas, Silvia García-Diaz, Salvador Campos, Silvia Sánchez-Serrano, Silvia Iniesta, Isabel Padró, Lucinda Sanchez-Eslava, Elena Fernández-Casado, Montse Sesma, Cristina Saura, Mari Carmen Rodríguez, Maria Rusiñol and Montse Jordana

Article Type: Research Article | First Published: January 31, 2017

Rheumatoid arthritis (RA) is a chronic inflammatory heterogeneous disease presenting with acute flares, showing a prevalence of 0.5% in Spanish population according to the study EPISER and an annual incidence of 8.3 cases per 100,000 population, and that in the absence of optimal and individualized treatment causes a long-term severe disability....
 

 Open Access DOI:10.23937/2469-5726/1510043

Relapsing Polychondritis

Jozef Rovensky and Marie Sedlackova

Article Type: Review Article | First Published: October 10, 2016

Relapsing polychondritis (RP) is a rare immune-mediated disease that may affect multiple organs. It is characterised by recurrent episodes of inflammation of cartilaginous structures and other connective tissues, rich in glycosaminoglycan. Clinical symptoms concentrate in auricles, nose, larynx, upper airways, joints, heart, blood vessels, inner ear, cornea and sclera....
 

 Open Access DOI:10.23937/2469-5726/1510042

TB: Falsely Accused? (A Case Report and Discussion)

Kelsy Greenwald and Jo Ann Ball

Article Type: Case Report | First Published: October 03, 2016

Interferon-Gamma Release Assays (IGRAs) in the past decade have become ubiquitous screening for tuberculosis (TB). Development of these interferon release tests helped screen for TB in patients at high risk, specifically those with human immunodeficiency virus (HIV). The blood test was designed to strongly stimulate interferon release when blood was exposed to a tube laced with TB antigens....
 

 Open Access DOI:10.23937/2469-5726/1510041

Salivary Glands Ultrasonography in Rheumatoid Arthritis Patients. Its Role in Early Detection of Secondary Sjogren's Syndrome

Amal Mohamad El-Barbary, Marwa Ahmed Aboelhawa, Abeer Abdelmenem Shahba, Noha Mohamed Shafik, Hala Elsayed Hamouda and Hossam Abdelhafiz Zaytoun

Article Type: Research Article | First Published: October 01, 2016

One hundred and fifty RA patients classified into two equal subgroups according to the presence of sicca symptoms, in addition to seventy five healthy controls. All patients were subjected to self-reported questionnaire about sicca symptoms, DAS 28, Unstimulated whole salivary flow rate (UWSFR), Schirmer's test, ESR, CRP, RF, Anti- CCP, Anti-Ro, Anti-La antibodies, serum and salivary CXC ligand 13 (CXCL13), B cell activating factor (BAFF), ultras...
 

 Open Access DOI:10.23937/2469-5726/1510040

MR Imaging of Degenerative Cartilage Lesions of the Knee Joint in Floor Layers and Graphic Designers

Soren Rytter, Birthe Lykke Thomsen, Birgitte Schutt Christensen and Lilli Kirkeskov

Article Type: Research Article | First Published: September 21, 2016

Kneeling work leads to an additional risk of developing knee osteoarthritis (OA). Previous studies have primarily been based on radiography, but radiography is limited by its inability to visualize articular cartilage, in which the earliest signs of OA occur. The objective of this explorative study, based on available data, was to examine the prevalence of magnetic resonance imaging (MRI)-detected knee cartilage lesions in male floor layers expos...
 

 Open Access DOI:10.23937/2469-5726/1510039

Implementation of Evidence-Based Practice in Rheumatology: What Sociodemographic, Social Cognitive and Contextual Factors Influence Health Professionals' Use of Research in Practice?

Neher M, Stahl C, Festin K and Nilsen P

Article Type: Research Article | First Published: September 17, 2016

Research on the use of research in rheumatology practice is largely lacking. This study attempts to fill this knowledge gap by exploring the degree to which evidence-based practice (EBP) is implemented in clinical rheumatology practice and identifying individual and organizational factors that may potentially affect research use in the clinical environment....
 

 Open Access DOI:10.23937/2469-5726/1510038

Impact of the Addition of Ginger Extract and Copper Sulphate to Glucosamine Sulphate on Il-1Beta-Stimulated Chondrocytes

Francis Rousset, Laurent Grange, Minh Vu Chuong Nguyen, Clara Pinosa-Zezza, Philippe Gaudin, Thierry Conrozier, Francoise Morel and Bernard Lardy

Article Type: Research Article | First Published: September 02, 2016

This study provided experimental evidence that glucosamine sulfate decreases ADAMTS5 expression and apoptosis. In addition, ginger root and copper sulphate decreased pro-MMP1 expression by regulating NOX4 activity. Our data suggest the implication of Heme Oxygenase-1 in the molecular mechanisms....
 

 Open Access DOI:10.23937/2469-5726/1510037

Chronic Large Joint Synovitis in Systemic Lupus Erythematosus: Finding What You Look For

B Hodkinson, I Okpechi and SA Botha-Scheepers

Article Type: Case Report | First Published: July 03, 2016

A 30-year-Black African female was diagnosed with SLE when she presented with a Coombs positive haemolytic anaemia, lymphopenia, polyarthritis, oral ulcers and a malar rash. Her antinuclear antigen (ANA) was positive, she had hypocomplementaemia and she was HIV negative. She was commenced on oral corticosteroids (initially high dose 60 mg/day and later weaned to 15 mg daily), chloroquine sulphate and azathioprine. Her blood counts and SLE symptom...
 

 Open Access DOI:10.23937/2469-5726/1510036

Vogt-Koyanagi-Harada-Syndrome Concurrent with Morbus Darier

Claudia Eve Thieme, Sibylle Winterhalter, Bianca Apitzsch and Nicole Stuebiger

Article Type: Case Report | First Published: June 02, 2016

Vogt-Koyanagi-Harada-syndrome (VKH) is a multisystemic, T-cell mediated autoimmune disorder which is characterized by bilateral granulomatous panuveitis with extraocular manifestations in the central nervous and auditory system as well as in the integumentary field. Neurological and auditory manifestations include aseptic meningitis, meningism, tinnitus and cerebrospinal fluid pleocytosis. Integumentary findings can include alopecia, poliosis and...
 

 Open Access DOI:10.23937/2469-5726/1510035

Association of Markers of Oxidative Stress, Medication Therapy and Life Habits in Fibromyalgia

Joao Eduardo Torrecillas Sartori, Luiz Fernando Cireia, Denise Poltronieri Martins, Gabriela do Prado Rocha, Juliany Roberta Cintra, Ana Luiza de Aquino Oliveira, Juliana Goncalves Yogolare, Lucas Romagnolli, Alexandre de Andrade Budin, Sabrina Mayara Cezario, Marcela Augusta de Souza Pinhel, Camila Ive Ferreira Oliveira, Doroteia Rossi da Silva Souza, Gerardo Maria de Araujo Filho and Lazslo Antonio Avila

Article Type: Research Article | First Published: May 10, 2016

Objective: To evaluate the association among genetic polymorphisms of glutathione S-transferase, oxidative stress, lifestyle habits and medication therapy in patients with fibromyalgia (FM). Patients and methods: A total of 187 women (22-84 years) were studied: 81 patients with fibromyalgia (G1) and 106 individuals without the disease (G2). They had their peripheral blood sample submitted for analysis of GSTM1 and GSTT1 polymorphisms, serum level...
 

 Open Access DOI:10.23937/2469-5726/1510034

HLA-DR Frequency in Individuals with Rheumatoid Arthritis and Lung Affection

Maria do Socorro Teixeira Moreira Almeida, Joao Vicente Moreira Almeida, Manoel Barros Bertolo, Catarina Fernandes Pires and Viriato Campelo

Article Type: Research Article | First Published: April 01, 2016

Rheumatoid arthritis (RA) is an autoimmune disease whose etiology is unknown, while its immunopathogenesis involves the participation of both genetic and environmental factors. Human leukocyte antigen DR4 (HLA-DR4) exhibits a strong association with RA in various populations and ethnic groups; in addition, a heightened frequency of HLA-DR1 among individuals with RA has been found in some populations....
 

 Open Access DOI:10.23937/2469-5726/1510033

Novel Application of Behavioral Assays Allows Dissociation of Joint Pathology from Systemic Extra-Articular Alterations Induced by Inflammatory Arthritis

Ann K Harvey, Mariah J Lelos, Claire J Greenhill, Ashley T Jones, Susanne P Clinch, Michael J Newton, Stephen B Dunnett, Sean L Wyatt, Anwen S Williams and Simon A Jones

Article Type: Research Article | First Published: April 01, 2016

Although rheumatoid arthritis (RA) is a disease of articular joints, patients often suffer from co-morbid neuropsychiatric changes, such as anxiety, that may reflect links between heightened systemic inflammation and abnormal regulation of the hypothalamic-pituitary-adrenal (HPA) axis. Here, we apply behavioral neuroscience methods to assess the impact of antigen-induced arthritis (AIA) on behavioral performance in wild type (WT) and interleukin-...
 

 Open Access DOI:10.23937/2469-5726/1510032

Meta-Analysis of the Clinical Efficacy of the Placebo Effect from Tumour-Necrosis-Factor Inhibitors to Treat Rheumatoid Arthritis after Methotrexate Failure

Julie Azais, Pascale Vergne-Salle, Christine Bonnet, Carine Dufauret-Lombard, Richard Treves and Philippe Bertin

Article Type: Research Article | First Published: March 31, 2016

Tumour-necrosis-factor (TNF) inhibitors, used to treat rheumatoid arthritis (RA), have non-specific (placebo effect) and specific effects. This meta-analysis appraises these effects within the first 3 months of treatment. Data were collected from ACR 20, 50 and 70 scores at week-24 from RA patients receiving TNF-blockers or a placebo after methotrexate (MTX) failure....
 

 Open Access DOI:10.23937/2469-5726/1510031

Erdheim-Chester Disease: A Case of Cardiac and Hypophyseal Involvement Showing Positive Response with High Dose Pegylated Interferon-Α

Annie HN Law and SI Yeo

Article Type: Case Report | First Published: February 07, 2016

Erdheim-Chester disease (ECD) is a rare form of non-Langerhans cell histiocytosis, with multifaceted clinical presentations. There are currently fewer than 550 cases reported in the literature. This case illustrates the protean manifestations of ECD with multisystem involvement, including skeletal and extra skeletal (cutaneous, cardiac, pituitary, retroperitoneal, and pulmonary) manifestations...
 

 Open Access DOI:10.23937/2469-5726/1510030

Biomechanical Stimulation Therapy - An Efficacious Method for Facial Scleroderma with Reduced Oral Aperture

Walter Berg, Ingo H Tarner, Gabriela Riemekasten, Ulf Muller-Ladner and Uwe Lange

Article Type: Research Article | First Published: January 26, 2016

Systemic sclerosis (SSc) is a chronic, severe connective tissue disorder characterized by a microangiopathy and excess deposition of connective tissue matrix in the skin and internal organs. Skin involvement is the most conspicuous manifestation of SSc, and based on its extent two distinct disease subsets are recognized, diffuse cutaneous (dcSSc) and limited cutaneous systemic sclerosis (lcSSc), with lcSSc affecting only the distal extremities an...
 

 Open Access DOI:10.23937/2469-5726/1510029

Anti-inflammatory Effect of Antioxidant Pequi (Caryocar Brasiliense) Oil Capsules and Antioxidant Effect of Vitamin D and Physical Activity on Systemic Lupus Erythematosus Patients

Thais Muniz Montalvao, Ana Luisa Miranda-Vilela, Cesar Koppe Grisolia and Leopoldo Luiz Santos-Neto

Article Type: Case Series | First Published: January 09, 2016

Systemic lupus erythematosus (SLE) is a chronic inflammatory, complex, multisystem autoimmune disease of multifactorial origin. It is characterized by a large set of antibodies, especially antinuclear antibodies. Its incidence rate varies from 1 to 10 per 100,000 persons/year and its prevalence rate is 20-70 per 100,000. It is a more frequent rare disease in women between 15 and 45 years old. The cause of SLE is still unknown; however, there is a...
 

 Open Access DOI:10.23937/2469-5726/1510028

Massive Serositis as the Initial Presentation of Systemic Lupus Erythematosus: A Report of Two Cases and Review of the Literature

Laura Geraldino-Pardilla Yevgeniya Gartshteyn and Fabian Mendoza

Article Type: Case Series | First Published: December 31, 2015

Large volume effusions as a manifestation of active systemic lupus erythematous (SLE) is rare, and when it does occur, it is usually associated with complications of chronic lupus disease, such as nephrotic syndrome, constrictive pericarditis, heart failure or Budd-Chiari syndrome. Massive serositis as a presenting feature of SLE is rare. We describe two adult cases of new onset SLE presenting with massive ascites in the first case, and large bil...
 

 Open Access DOI:10.23937/2469-5726/1510027

Aspirin-Triggered Resolvin D1 Versus Dexamethasone in the Treatment of Sjogren's Syndrome-Like NOD/ShiLtJ Mice - A Pilot Study

Justin T Easley, Joel W Nelson, Rachel E Mellas, Salah Sommakia, Chunhua Wu, Bryan Trump, and Olga J Baker

Article Type: Research Article | First Published: December 17, 2015

Resolvin D1 (RvD1) and its aspirin-triggered epimeric form (AT-RvD1) are endogenous lipid mediators (derived from docosahexaenoic acid, DHA) that control the duration and magnitude of inflammation in models of complex diseases. Our previous studies demonstrated that RvD1-mediated signaling pathways are expressed and active in salivary glands from rodents and humans. Furthermore, treatment of salivary cells with RvD1 blocked TNF- -mediated inflamm...
 

 Open Access DOI:10.23937/2469-5726/1510026

A Rare Coexistence of Seronegative Enthesopathy and Arthropathy Syndrome with Familial Mediterranean Fever

Hakan Genc, Alper Gumustepe, Fikriye Figen Ayhan and Aynur Karagoz

Article Type: Case Report | First Published: November 18, 2015

The juvenile-onset spondyloarthropathies begin at age of 16 years or younger and are associated with the HLA-B27 allele. They are classified as the enthesitis-related arthritis (ERA) subgroup of juvenile idiopathic arthritis (JIA) by the international league of associations for rheumatology (ILAR) [1]. Although the adult form has inflammatory low back pain as the predominant clinical symptom, the juvenile form has peripheral enthesitis and arthri...
 

 Open Access DOI:10.23937/2469-5726/1510025

In the Idiopathic Inflammatory Myopathies, How Significant is Creatine Kinase Levels in Diagnosis and Prognosis? A Case Study and Review of the Literature

Travis C Sizemore

Article Type: Case Report | First Published: November 18, 2015

The clinical significance of creatine kinase [CK] levels in idiopathic inflammatory myopathies [IIM] has varied between studies. CK levels continue to be the most sensitive laboratory marker for muscle disease in IIM but vary depending upon the disease entity. The goal of this article was to further elucidate the clinical significance of CK levels in the setting of IIM, including role of CK in diagnostics and prognostication. A case report was de...
 

 Open Access DOI:10.23937/2469-5726/1510024

Hypercoagulation in Patients with Rheumatoid Arthritis Correlates with Activation of Act1/NF-kb Signaling Pathway

Pingheng Zhang, Jian Liu and Bing Tan

Article Type: Research Article | First Published: November 16, 2015

Peripheral blood samples were taken from 30 RA patients and 20 healthy volunteers, as controls. Ex vivo correlates of disease severity, such as C-reactive protein, erythrocyte sedimentation rate, anti-cyclic citrullinated peptide and rheumatoid factor, and immunological activation, such as interleukin (IL)-10, IL-17 and IL-6 were measured biochemically. Factors derived from the coagulation fibrinolytic system were also determined, such as the num...
 

 Open Access DOI:10.23937/2469-5726/1510023

Fatigue in Patients with Early-Stage Systemic Lupus Erythematosus Before Receiving Corticosteroid Therapy: A Prospective Cross-Sectional Study

Katsuji Nishimura, Masako Omori, Yasuhiro Katsumata, Eri Sato, Yasushi Kawaguchi, Masayoshi Harigai, Hisashi Yamanaka and Jun Ishigooka

Article Type: Original Article | First Published: October 31, 2015

Objective: Fatigue has been intensively studied in patients with systemic lupus erythematosus (SLE). However, previous studies have mostly included patients with long-term disease who have been treated with corticosteroids. We investigated fatigue in corticosteroid-naive patients with early-stage SLE. Methods: Forty-three SLE inpatients without neuropsychiatric SLE manifestations and 30 healthy control subjects with similar demographic characteri...
 

 Open Access DOI:10.23937/2469-5726/1510022

Lupus-Associated Pancreatitis: Clinical Aspects

Maria Helena Favarato

Article Type: Review Article | First Published: September 28, 2015

Systemic lupus erythematosus (SLE) is a systemic autoimmune inflammatory disease, with several different clinical manifestations. Its annual incidence is about 5 cases per 100000 inhabitants. The prevalence is around 52 cases per 100000 inhabitants. The gastrointestinal tract may be affected, either by the disease itself or by adverse reactions of medications or by opportunistic infections. Although common, the incidence of gastrointestinal manif...
 

 Open Access DOI:10.23937/2469-5726/1510021

Eosinophilic Fasciitis Treated with Tocilizumab: Demonstration of Efficacy after Withdrawal and Re-Challenge in a Patient

Glen T D Thomson, Janine L Johnston and Brent R J Thomson

Article Type: Case Report | First Published: September 28, 2015

A 41-year-old man presented with clinical features of eosinophilic fasciitis (EF) confirmed on biopsy. The patient responded to high-dose prednisone but subsequent steroid sparing medication including methotrexate, hydroxychloroquine, etanercept, golimumab and rituximab failed to deliver steroid sparing response. Tocilizumab provided rapid and sustained improvement in the patient's symptoms and signs. Withdrawal of tocilizumab resulted in a flare...
 

 Open Access DOI:10.23937/2469-5726/1510020

A Case of Rhabdomyolysis and Polyarticular Inflammatory Arthritis May be the Initial Presentation of Chronic Myelogenous Leukemia (CML)

Yelliann Ruiz-Irizarry and Petros Efthimiou

Article Type: Case Report | First Published: September 24, 2015

Rhabdomyolysis and inflammatory arthritis are common rheumatologic conditions that manifest in people of all ages. Proximal muscle weakness associated to rhabdomyolysis is frequently the initial presentation of inflammatory myopathies such as dermatomyositis (DM) and polymyosistis (PM) both, extensively described in literature to be related to paraneoplastic process. Inflammatory arthritis has been associated to certain paraneoplastic syndromes, ...
 

 Open Access DOI:10.23937/2469-5726/1510019

A MRI Assessment of the Response of Chronic, Occult, Synovial-Based Inflammation of Gout to Serum Urate Lowering Therapy

John D. Carter, Michelle Patelli, Scott R. Anderson, Neelesh Prakash, Ernesto J. Rodriquez and Louis R. Ricca

Article Type: Research Article | First Published: September 09, 2015

Clinical gout begins as an acute intermittent and intensely painful arthritis that can progress to a chronic, inflammatory, destructive condition. The initial episodes may last several days and are often followed by pain-free, inter-critical periods that may last months to years. Chronic gouty arthritis is manifested by shorter inter-critical periods, boney destructive changes and possible development of visible tophi. Advanced gout leads to chro...
 

 Open Access DOI:10.23937/2469-5726/1510018

A Flowchart For Understandıng Ankylosing Spondylitis Management Recommendatıons of Asas/Eular

Nihal Ozaras

Article Type: Letter | First Published: August 03, 2015

Ankylosing spondylitis (AS) is one of the most frequently seen rheumatic diseases in clinical practice. Its treatment is defied by the Assessment of SpondyloArthritis international Society (ASAS)/ European League Against Rheumatism (EULAR). A flowchart is designed to easily understand this treatment strategy....
 

 Open Access DOI:10.23937/2469-5726/1510017

Pathological Relationship of Osteomalacia at the Site of Atypical Periprosthetic Femoral Shaft Fracture after Typical Femoral Neck Fracture Occurred in the Patient with Rheumatoid Arthritis: A Case Report

Takanori Wakayama, Yoshitomo Saita, Tomonori Baba, Hidetoshi Nojiri and Kazuo Kaneko

Article Type: Case Report | First Published: July 17, 2015

We describe a patient who suffered an atypical periprosthetic femoral shaft fracture two years after surgical treatment for a typical osteoporotic femoral neck fracture. This patient had been suffering from rheumatoid arthritis (RA), steroid-induced diabetes, and steroid-induced osteoporosis, and had undergone long term administration of glucocorticoids (GCs), bisphosphonates (BPs), and active vitamin D (aVD) analog. Prodromal pain and periprosth...
 

 Open Access DOI:10.23937/2469-5726/1510016

A Case of Malignant Malaria Complicated By Symmetrical Peripheral Gangrene

Amira A Shahin, Noha M Abdelbaky and Sahar S Emam

Article Type: Case Report | First Published: July 09, 2015

Symmetrical peripheral gangrene (SPG) is a rare complication of malaria. The ischemic changes begin distally and progress rapidly to cause irreversible tissue necrosis requiring amputation in almost all cases. We report a case of a 21-years-old female with malignant malaria complicated by SPG. Our treatment regimen includes corticosteroids in addition to the anti-malaria and anticoagulation therapy. Clinicians should be aware of this entity as ea...
 

 Open Access DOI:10.23937/2469-5726/1510015

Anxiety and its Impact on Osteoarthritis Pain: An Update

Prof. Ray Marks

Article Type: Review Article | First Published: July 03, 2015

Anxiety is a very common psychological syndrome occurring in the adult population either as a trait or specific condition, and/or in response to a variety of situations, especially adverse health conditions. This narrative review examines the extent to which anxiety may preside among adults with a diagnosis of osteoarthritis, regardless of site, and its linkage to the pain experience. Drawn from the English language peer reviewed work over the la...
 

 Open Access DOI:10.23937/2469-5726/1510014

Treatment of Refractory Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis with High Dose Anakinra

Kwong Jenitta M, Peng Tammy, Mohiuddin Adil, Chefiz Dalya, Craig Vicki, Weissmann David, Moorthy L Nandini, Weiss Pamela F, Cron Randy Q and Andujar Joanna

Article Type: Case Report | First Published: June 11, 2015

We report a case of MAS occurring during the initial presentation of sJIA treated with high dose anakinra. Excess interleukin-1 can lead to the clinical and laboratory findings of sJIA and MAS, and the up regulation of interleukin-6. Uncontrolled production and activation of macrophages and T lymphocytes lead to MAS manifestations, including prolonged high fever, pancytopenia, coagulopathy, lymphadenopathy, hepatic insufficiency, and neurologic d...
 

 Open Access DOI:10.23937/2469-5726/1510013

Effect of Etanercept on Anti-Carbamylated Protein Antibodies in Patients with Rheumatoid Arthritis

Francesca Romana Spinelli, Arbi Pecani, Fulvia Ceccarelli, Cristiano Alessandri and Fabrizio Conti

Article Type: Research Article | First Published: May 23, 2015

Rheumatoid Arthritis (RA) is a systemic, chronic inflammatory disease characterized by inflammation of synovial joints and production of autoantibodies such as Rheumatoid Factor and antibodies directed against modified proteins - i.e. anti-citrullinated peptides antibody (ACPA). Carbamylation, as a post translational modification, has been recently associated to RA since anticarbamylated protein antibodies (anti-CarP) have been detected in the se...
 

 Open Access DOI:10.23937/2469-5726/1510012

Pathogenesis of Bone Erosions in Rheumatoid Arthritis: Not Only Inflammation

Maurizio Rossini, Angelo Fassio, Luca Idolazzi, Ombretta Viapiana, Elena Fracassi, Giovanni Adami, Maria Rosaria Povino, Maria Vitiello and Davide Gatti

Article Type: Review Article | First Published: May 22, 2015

It is a matter of fact that the inflammatory pathogenesis does not explain all the skeletal manifestations of Rheumatoid Arthritis (RA), and the development of bone involvement is sometimes unconnected from the clinical scores of inflammation. On the basis of recent studies, we would like to make a point of the new available evidence about the metabolic pathogenic component of bone erosions....
 

 Open Access DOI:10.23937/2469-5726/1510011

Screening for Mucopolysaccharidoses in Pediatric Rheumatology Clinic

Magrini D, Lehman TJA and Moorthy LN

Article Type: Research Article | First Published: May 21, 2015

Mucopolysaccharidosis (MPS) is a rare group of inherited lysosomal storage disorders that is associated with multiple symptoms including joint stiffness, misshapen bones, reduced hand function, frequent otitis media, 'thickened' facial features, hearing problems, vision problems and heart complications. We conducted this study to determine how many (if any) children that come to pediatric rheumatology have unrecognized MPS and if routine screenin...
 

 Open Access DOI:10.23937/2469-5726/1510010

Spondyloarthropathy, Spondyloarthritis, Axial Spondyloarthritis: A Rose by any other Name?

Bruce Rothschild

Article Type: Editorial | First Published: May 13, 2015

What is a diagnosis, but recognition of a phenotype? The term spondyloarthropathy is much debated, with alternative appellation suggestions. Spondyloarthritis and spondylarthritis have been suggested, but there has also been a movement to separate peripheral and axial disease, with the latter referred to as axial spondyloarthropathy....
 

 Open Access DOI:10.23937/2469-5726/1510009

Tei Index in a Sample of Patients with Ankylosing Spondylitis

Rodrigo Eduardo Rosa, Admar Moraes de Souza, Lucio Ricardo Hiurko Felippe, Pedro Grachinski Buiar, Pedro Gabriel Lorencetti, Chayanne Natielle Rossetto and Valderilio Feijo Azevedo

Article Type: Research Article | First Published: April 13, 2015

Ankylosing spondylitis (AS) is an inflammatory disease of immunological origin which has been correlated with higher cardiovascular risk. Although the risk factors are not clear, many cardiac alterations have been described, such as conduction disturbances, coronary heart disease, aortic root dilation, cardiac valve alterations, and ventricular diastolic dysfunction....
 

 Open Access DOI:10.23937/2469-5726/1510008

Osteoimmunological Aspects on Inflammation and Bone Metabolism

Uwe Lange, Gabriel Dischereit, Elena Neumann, Klaus Frommer, Ingo H. Tarner and Ulf Muller-Ladner Kerckhoff-Klinik

Article Type: Review Article | First Published: April 09, 2015

Bone remodelling is characterized by a balance between bone resorption and bone formation. The osteoblasts are responsible for bone synthesis and the osteoclasts for bone resorption. A finely adjusted interaction between molecular mechanisms results, via cytokines, hormones and growth factors, in homeostasis of bone metabolism....
 

 Open Access DOI:10.23937/2469-5726/1510007

Individualized Rheumatoid Arthritis Patient Care Means more than Achieving a Number

Burkhard F. Leeb

Article Type: Commentary | First Published: March 03, 2015

The therapeutic scope of inflammatory rheumatic diseases and of Rheumatoid Arthritis (RA) in particular, has increased dramatically over the last twenty years leading to incredibly better chances for the patients. Simultaneously disease activity assessment has become more and more important, not only to document the patient's disease course, but also for justifying the application of potentially dangerous and expensive remedies....
 

 Open Access DOI:10.23937/2469-5726/1510006

Connective Tissue Disease-Associated Interstitial Lung Disease

Marcelo Fernandez Casares

Article Type: Editorial | First Published: March 02, 2015

Interstitial Lung Diseases (ILDs) also known as Diffuse Parenchymal Lung Disease (DPLD), include a large group of lung diseases characterized by various patterns of inflammation and fibrosis on high-resolution CT and in lung biopsy....
 

 Open Access DOI:10.23937/2469-5726/1510005

Suppression of Experimental Arthritis through AMP-Activated Protein Kinase Activation and Autophagy Modulation

Huimin Yan, Hui-Fang Zhou, Ying Hu and Christine T.N. Pham

Article Type: Research Article | First Published: February 28, 2015

Autophagy plays a central role in various disease processes. However, its contribution to inflammatory arthritides such as rheumatoid arthritis (RA) is unclear. We observed that autophagy is engaged in the K/BxN serum transfer model of RA but autophagic flux is severely impaired. Metformin is an anti-diabetic drug that has been shown to stimulate autophagy. Induction of autophagic flux, through metformin-mediated AMP-activated protein kinase (AMP...
 

 Open Access DOI:10.23937/2469-5726/1510004

Non-Operative Treatment of Knee Osteoarthritis: Fear the Future?

Eduardo Branco de Sousa

Article Type: Editorial | First Published: February 23, 2015

Non-operative treatment of knee osteoarthritis has gained special interest between patients and orthopedic surgeons, not only to alleviate pain and improve function, but also to postpone joint replacements. Projections showed an increase of 673% in the number of arthroplasties to be performed in the United States through 2030....
 

 Open Access DOI:10.23937/2469-5726/1510003

Differential Diagnosis in Upper Back Pain

Nihal Ozaras

Article Type: Editorial | First Published: February 21, 2015

Upper back pain (UBP) is the pain experienced at the thoracic spine region. Spinal pain prevalence is 66 per 100 people and15% them is UBP. Although it is so frequent, it is less studied than neck or low back pain.It can be seen at any period of life, from childhood to elderly.This article briefly describes differential diagnosis in UBP....
 

 Open Access DOI:10.23937/2469-5726/1510002

Difficulties in Defining a Clinical Score for Acute Flare-Ups in an Osteoarthritic Knee

Hassan M Bassiouni and Ahmed A Negm

Article Type: Editorial | First Published: February 19, 2015

The basic idea of this editorial was to try to propose new techniques and laboratory measurements for future incorporation into a new score for identifying an acutely inflamed osteoarthritic knee joint. In the area of research, defining clinical status was always a hurdle to proper patient recruitment because working on quiet cases of OA with minimal to moderate pain is totally different from working on acute cases of OA with a lot of pain. Hence...
 

 Open Access DOI:10.23937/2469-5726/1510001

Subchondral Bone: An Emerging Target for Treatment of Osteoarthritis

Lukas A. Holzer

Article Type: Editorial | First Published: February 15, 2015

Osteoarthritis (OA) is a long-term chronic disease that is characterized by the deterioration of cartilage in joints resulting in stiffness, pain and impaired range of motion. OA is a disease that is associated with ageing. However, there are various factors e.g. obesity, lack of exercise, genetical abberations, occupation, trauma and gender that contribute to progression of OA. Osteoarthritis is the most common form of arthritis. The World Healt...

Editor-in-chief


ClinMed International Library

3
0
1
0

Articles Published

All articles are fully peer reviewed, free to access and can be downloaded from our ClinMed archive.

Contact our editorial office

Editors' Picks

Can Genetic Testing Provide Information to Develop Customized Nutrigenomic..
Pubmed ID:26225358 | PMC ID:PMC4516390
Acute Ovarian Insufficiency and Uterine Infarction Following Uterine Artery..
Pubmed ID:26523290 | PMC ID:PMC4623578
Challenges of Fertility Sparing Ovarian Surgery Imposed by Krukenberg..
Pubmed ID:26366440 | PMC ID:PMC4563814
Ultra-High Resolution Optical Coherence Tomography Imaging of Unilateral..
Pubmed ID:27398405 | PMC ID:PMC4936830
Hypothesizing that a Pro-Dopaminergic Regulator (KB220z™ Liquid Variant)..
Pubmed ID:29034323 | PMC ID:PMC5638455
Titanates and Titanate-Metal Compounds in Biological Contexts..
Pubmed ID:26430701 | PMC ID:PMC4587770
MyHEART: A Non Randomized Feasibility Study of a Young Adult..
Pubmed ID:28191544 | PMC ID:PMC5300088
Exenatide Effects on Cardiometabolic Risk and Weight in Adolescents..
Pubmed ID:27182560 | PMC ID:PMC4864000
A New Animal Model to Study Endogenous Cardiotonic Steroids and the Progression..
Pubmed ID:26457335 | PMC ID:PMC4599712
Common Genetic Variation in Circadian Rhythm Genes and Risk of..
Pubmed ID:26807442 | PMC ID:PMC4722961
Active Hexose Correlated Compound Activates Immune Function to Decrease..
Pubmed ID:27790645 | PMC ID:PMC5079436
The Extraction, Anticancer Effect, Bioavailability, and..
Pubmed ID:27790646 | PMC ID:PMC5079443
Kyphosis and Sleep Characteristics in Older Persons: The Rancho..
Pubmed ID:28480455 | PMC ID:PMC5419044
Suppression of Experimental Arthritis through AMP-Activated Protein..
Pubmed ID:26120598 | PMC ID:PMC4479345
Aspirin-Triggered Resolvin D1 Versus Dexamethasone in the Treatment of..
Pubmed ID:27110599 | PMC ID:PMC4841619
Elder Mistreatment and its Subtypes across Different Sociodemographic and..
Pubmed ID:26973979 | PMC ID:PMC4786076
Balance and its Clinical Assessment in Older Adults - A Review..
Pubmed ID:26942231 | PMC ID:PMC4773046
Caregiver Abuse of Chicago Chinese Older Adults in a Community..
Pubmed ID:27606358 | PMC ID:PMC5008847
The Relationship of Older Adults' Physical Pain to Depression and..
Pubmed ID:27642644 | PMC ID:PMC5023019
Sphingosine 1-Phosphate Receptor 2 Regulates the Migration,..
Pubmed ID:27275017 | PMC ID:PMC4888913
Mammary Epithelial Cell Lineage Analysis via the Lyon's Hypothesis..
Pubmed ID:27453956 | PMC ID:PMC4957014
Epigenetic Loss of MLH1 Expression in Normal Human Hematopoietic Stem Cell..
Pubmed ID:27570841 | PMC ID:PMC4996274
Long-Term Function, Pain and Medication Use Outcomes of Radiofrequency..
Pubmed ID:26005713 | PMC ID:PMC4440581
Caspase Cleaved Tau in Alzheimer's Disease: A Therapeutic Target..
Pubmed ID:25639474 | PMC ID:PMC4308811
Corpora Amylacea in Neurodegenerative Diseases: Cause or Effect?..
Pubmed ID:26550607 | PMC ID:PMC4634668
Differences in ME and CFS Symptomology in Patients with Normal and..
Pubmed ID:28713856 | PMC ID:PMC5510614
Gene-Specific Promoter Methylation Status in Hormone-Receptor-Positive..
Pubmed ID:26005715 | PMC ID:PMC4440485
A Derivative of Differentiation-Inducing Factor-3 Inhibits PAK1..
Pubmed ID:26688830 | PMC ID:PMC4682050
Overcoming Endocrine Resistance in Hormone-Receptor Positive Advanced..
Pubmed ID:26726315 | PMC ID:PMC4697745
Zinc Ionophore (Clioquinol) Inhibition of Human ZIP1-Deficient Prostate..
Pubmed ID:26878064 | PMC ID:PMC4751054
Electron Microscopic Analysis of Silicate and Calcium Particles..
Pubmed ID:27158665 | PMC ID:PMC4858188
Effects of chest physical therapy in patients with non-tuberculous mycobacteria
Pubmed ID:28804763 | PMC ID:PMC5552049
A Community-Based Exercise and Support Group Program Improves Quality..
Pubmed ID:26640827 | PMC ID:PMC4667740
Four Weeks of Balance Training Does Not Affect Ankle Joint Stiffness in Subjects..
Pubmed ID:27642647 | PMC ID:PMC5025258
Social Ecology and Diabetes Self-Management among Pacific Islanders..
Pubmed ID:28736764 | PMC ID:PMC4516390
Examining Characteristics of Hospitalizations in Heart Failure Patients: Results..
Pubmed ID:28736765 | PMC ID:PMC5517048