Severe MTX Toxicity in Rheumatic Diseases - Analysis of 22 Cases
Bergner R, Wadsack D and Loffler C
Article Type: REVIEW ARTICLE | First Published: Febrayry 25, 2019
Severe MTX (methotrexate) toxicity due to low dose MTX used in rheumatic diseases is rare but linked with a high mortality ranging from 13 to 44%. We analyzed 22 cases with a minimum toxicity of CTC (common toxicity criteria) grade 2, that were admitted to our hospital. We retrospectively analyzed epidemiological data, the weekly MTX dosage, renal function before and at the beginning of the adverse event, co-medication with influence on MTX toxicity or on renal function and potential other co-fa...
Muscle Ultrasound in Inflammatory Myopathies: A Critical Review
Kristofoor E Leeuwenberg and Jemima Albayda
Article Type: Review Article | First Published: February 11, 2019
Muscle ultrasonography is an upcoming tool in the evaluation of neuromuscular disorders. It is easily applicable in multiple clinical settings, has no contraindications, and provides a cost-effective alternative to other imaging modalities such as MRI. However, a known disadvantage of ultrasound is its dependence on examiner expertise. Furthermore, the assessment of muscle quality is done mainly through an assessment of muscle echo intensity, which is affected by machine/system settings, hamperi...
Clinical Pharmacological Management Status of Systemic Lupus Erythematous Population: Situational Analysis
Farida Al Balushi, Issa Al Salmi, Abdel Masiah Metry, Mohammed Abdalla Yousef and Suad Hannawi
Article Type: Research Article | First Published: December 20, 2018
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease that has various manifestations among different populations. This study aims to provide an overview of medical pharmacological management that SLE population received immediately at time of diagnosis. This is a retrospective analysis using patients’ registry medical information system. All patients diagnosed with SLE were reviewed by accessing their medical records including pharmacy prescription and dispersions at the Royal ...
Rheumatologic Diseases as Paraneoplastic Syndromes - A Paradigmatic Case
Ines Rego de Figueiredo, Rita Vieira Alves, Sara Guerreiro Castro, Filipa Lourenco, Ana Margarida Antunes, Heidi Gruner and Antonio Panarra
Article Type: Case Report | First Published: October 15, 2018
Rheumatic diseases can be a paraneoplastic syndrome for an occult neoplasia. Some syndromes are more characteristic than others. In this case report, we present a patient with musculoskeletal symptoms suggestive of both carcinomatous arthritis and polymyalgia rheumatica that was shown to have adenocarcinoma of the lung. The musculoskeletal symptoms accompanied the course of the disease, disappearing with the treatment and re-occurring when it relapsed. We present a 63-year-old male, native from ...