Current Issue
Brief Report Open AccessTrend of Frequency and Outcome of Reactive Arthritis in Japanese Patients with Bladder Cancer following Intravesical BCG Therapy over the Last 20 YearsYoshinori Taniguchi, Hirofumi Nishikawa, Yasuhiko Yoshinaga, Eri Amano, Shigeto Kobayashi and Yoshio TeradaJ Rheum Dis Treat Volume 4, Issue 2Abstract: Reactive arthritis (ReA) is a sterile arthritis occurring in a genetically predisposed individual, secondary to an extra-articular infection, usually of the gastrointestinal or genitourinary tract. Intravesical instillation of Bacillus Calmette-Guerin (iBCG) is used as an effective immunotherapy of bladder cancer. Despite of the clinical efficacy, ReA could develop as adverse event and the frequencies are known as about 0.5 to 1% in Western countries and 2.0% in Japan. However, the trend of frequency and outcome of iBCG-induced ReA in Japanese patients have not been assessed in multi-centre studies. |
Case Report Open AccessMultifocal Avascular Necrosis of the Lunate and Triquetrum in a Child with Systemic Lupus ErythematosusRoberts DC, Jester A, Southwood T, Johnson K and Oestreich KJ Rheum Dis Treat Volume 4, Issue 2Abstract: Avascular necrosis is a known complication of systemic lupus erythematosus. We report an unusual case of avascular necrosis affecting both the lunate and triquetrum in a child with this condition. Vasculitis, synovitis and IgM anticardiolipin antibodies were probable predisposing factors. The use of arthroscopic synovial debridement improves symptoms even in the presence of carpal chondromalacia and potentially delays the need for salvage surgery. |
Review Article Open AccessAutoimmunity and Lymphoma: A Brief ReviewEdward B MillerJ Rheum Dis Treat Volume 4, Issue 2Abstract: The relationship between the immune system and both Hodgkin's (HL) and Non-Hodgkin's (NHL) lymphomas is a complex bidirectional process which has fascinated researchers and clinicians for many years. Lymphomas of all types are known to be associated with autoimmune paraneoplastic manifestations, and conversely are recognized in increased frequency in patients with pre-existing autoimmune diseases. |
Research Article Open AccessTen Year Risk of Cardiovascular Events during anti-TNF Alpha in Rheumatoid Arthritis PatientsIlaria Cavazzana, Carlo Alberto Scire, Francesca Dallara, Maria Lorenza Muiesan, Angela Tincani and Franco FranceschiniJ Rheum Dis Treat Volume 4, Issue 2Abstract: Rheumatoid arthritis (RA) is a chronic and systemic inflammatory disease, characterized by an increased risk of premature death, largely due to cardiovascular disease (CVD) and particularly to coronary artery disease (CAD). In addition to classical Framingham CV risk factors, the inflammatory burden of the disease leads to the development of early and accelerated atherosclerosis, mediated by cytokines, immune complex, abnormal lipid metabolism and endothelial dysfunction. |
Research Article Open AccessModulation of Histone Deacetylases (HDACs) Expression in Patients with and without Systemic Lupus Erythematosus: Possible Drug Targets for TreatmentKenneth L Wiley, Edward Treadwell, Kayihura Manigaba, Beverly Word, Jarren Oates and Beverly D Lyn-CookJ Rheum Dis Treat Volume 4, Issue 2Abstract: There is increasing evidence that epigenetic factors may play a role in the pathogenesis of Systemic Lupus Erythematosus (SLE). Both global and gene specific methylation is known to occur in lupus patients, as well as, changes in histone acetylation status. Histone acetylation is associated with active chromatin or activation of genes, whereas histone deacetylase (HDAC) activity is associated with silencing of genes. Therefore, HDACs have been targeted as potential therapeutic targets for a number of diseases, including lupus. |
Volume 4
Issue 2
Issue 2