Current Issue

Brief Report Open Access

Trend of Frequency and Outcome of Reactive Arthritis in Japanese Patients with Bladder Cancer following Intravesical BCG Therapy over the Last 20 Years

Yoshinori Taniguchi, Hirofumi Nishikawa, Yasuhiko Yoshinaga, Eri Amano, Shigeto Kobayashi and Yoshio Terada
J Rheum Dis Treat Volume 4, Issue 2

Abstract: Reactive arthritis (ReA) is a sterile arthritis occurring in a genetically predisposed individual, secondary to an extra-articular infection, usually of the gastrointestinal or genitourinary tract. Intravesical instillation of Bacillus Calmette-Guerin (iBCG) is used as an effective immunotherapy of bladder cancer. Despite of the clinical efficacy, ReA could develop as adverse event and the frequencies are known as about 0.5 to 1% in Western countries and 2.0% in Japan. However, the trend of frequency and outcome of iBCG-induced ReA in Japanese patients have not been assessed in multi-centre studies.

PDF   Full Text   DOI: 10.23937/2469-5726/1510064

Case Report Open Access

Multifocal Avascular Necrosis of the Lunate and Triquetrum in a Child with Systemic Lupus Erythematosus

Roberts DC, Jester A, Southwood T, Johnson K and Oestreich K
J Rheum Dis Treat Volume 4, Issue 2

Abstract: Avascular necrosis is a known complication of systemic lupus erythematosus. We report an unusual case of avascular necrosis affecting both the lunate and triquetrum in a child with this condition. Vasculitis, synovitis and IgM anticardiolipin antibodies were probable predisposing factors. The use of arthroscopic synovial debridement improves symptoms even in the presence of carpal chondromalacia and potentially delays the need for salvage surgery.

PDF   Full Text   DOI: 10.23937/2469-5726/1510063

Review Article Open Access

Autoimmunity and Lymphoma: A Brief Review

Edward B Miller
J Rheum Dis Treat Volume 4, Issue 2

Abstract: The relationship between the immune system and both Hodgkin's (HL) and Non-Hodgkin's (NHL) lymphomas is a complex bidirectional process which has fascinated researchers and clinicians for many years. Lymphomas of all types are known to be associated with autoimmune paraneoplastic manifestations, and conversely are recognized in increased frequency in patients with pre-existing autoimmune diseases.

PDF   Full Text   DOI: 10.23937/2469-5726/1510062

Research Article Open Access

Ten Year Risk of Cardiovascular Events during anti-TNF Alpha in Rheumatoid Arthritis Patients

Ilaria Cavazzana, Carlo Alberto Scire, Francesca Dallara, Maria Lorenza Muiesan, Angela Tincani and Franco Franceschini
J Rheum Dis Treat Volume 4, Issue 2

Abstract: Rheumatoid arthritis (RA) is a chronic and systemic inflammatory disease, characterized by an increased risk of premature death, largely due to cardiovascular disease (CVD) and particularly to coronary artery disease (CAD). In addition to classical Framingham CV risk factors, the inflammatory burden of the disease leads to the development of early and accelerated atherosclerosis, mediated by cytokines, immune complex, abnormal lipid metabolism and endothelial dysfunction.

PDF   Full Text   DOI: 10.23937/2469-5726/1510061

Research Article Open Access

Modulation of Histone Deacetylases (HDACs) Expression in Patients with and without Systemic Lupus Erythematosus: Possible Drug Targets for Treatment

Kenneth L Wiley, Edward Treadwell, Kayihura Manigaba, Beverly Word, Jarren Oates and Beverly D Lyn-Cook
J Rheum Dis Treat Volume 4, Issue 2

Abstract: There is increasing evidence that epigenetic factors may play a role in the pathogenesis of Systemic Lupus Erythematosus (SLE). Both global and gene specific methylation is known to occur in lupus patients, as well as, changes in histone acetylation status. Histone acetylation is associated with active chromatin or activation of genes, whereas histone deacetylase (HDAC) activity is associated with silencing of genes. Therefore, HDACs have been targeted as potential therapeutic targets for a number of diseases, including lupus.

PDF   Full Text   DOI: 10.23937/2469-5726/1510060

Volume 4
Issue 2