International Journal of Respiratory and Pulmonary Medicine is an open access and bimonthly journal which globalizes the awareness of this medicinal and clinical information freely without any subscription for the online users. We process and accept all types of articles including original papers, reviews, short commentaries, case reports and many more. The board for the journal includes specialists, pharmacologists, scientists, practioners, and professors. Published articles undergo a detailed peer-reviewed process by professionals with the same backgrounds. We truly welcome kind suggestions from the readers which are within the scope of the journal.
The journal mainly focuses on human pulmonary and respiratory health. Focus topics include the lungs, respiration (oxygen and carbon dioxide exchange), respiratory diseases, epidemiology, treatments, recent advances and therapeutic interventions. Tobacco usage, family history, obesity, HIV/AIDS, diet, and chemical exposures that are the major risk factors for respiratory diseases constitute a significant portion of the scope of the journal. Through open access, published work is freely available, and upon acceptance and formatting, becomes immediately available to other professionals.
Articles Search by Keyword | Journal title | Author name | DOI
Open Access DOI:10.23937/2378-3516/1410118
Hatice Daldal, Musa Yigit and Yavuz Bardak
Article Type: Original Article | First Published: August 31, 2019
142 eyes of 71 consecutive patients with COPD who are applied to ophthalmology clinic were included in the retrospective study from January 2012 to August 2013. Trauma, ophthalmologic surgery history, diabetic retinopathy, uveitis, chorioretinitis, retinitis pigmentosa, retinal detachment and tears in the anamnesis and ophthalmologic examination were excluded from study. The visual acuity of the patients was assessed using Snellen chart. Intraocular pressure was measured with applanation tonomet...
Open Access DOI:10.23937/2378-3516/1410117
Sinem Nedime Sokucu, Cengiz Ozdemir, Ozlem Kahya, Seda Tural Onur and Levent Dalar
Article Type: Case Report | First Published: August 29, 2019
Lipomas are unsual tumors endobroncially and they make 0.1 - 0.5% of lung tumors. Diagnosis is often misleading due to these non-specific symptoms and the appearance of the mass on imaging studies. Biopsy is the key feature for the diagnosis. The treatment for endobronchial lipoma is surgical or endoscopic resection. Early treatment may prevent distal lung damage. A patient with a mass lesion as a coincidental finding after chest trauma diagnosed as endobronchial fibrolipomatosis. Endobronchial ...
Open Access DOI:10.23937/2378-3516/1410116
Zainab Syed, Ro- Jay Reid and Roberto Solis
Article Type: Research Article | First Published: July 25, 2019
Approximately 30 million annual clinic visits are attributed to cough in the United States. Moreover, evaluation and management of persistent cough in pulmonary clinics account for roughly 40% of patient volume. The most common etiologies are: Upper airway cough syndrome (UACS), asthma, non-asthmatic eosinophilic bronchitis (NAEB) and gastro-esophageal reflux disease (GERD) - all of which are treatable. However, despite avoidance of triggers and medical therapy, there remains an elusive diagnosi...
Open Access DOI:10.23937/2378-3516/1410115
Jeffrey Miller and Jean Elwing
Article Type: Case Report | First Published: July 11, 2019
We report a case of a 36-years-old female with known Fibrosing Mediastinitis (FM) suspected from prior Histoplamosis infection who presented for medical induction of first pregnancy. The case centers on the outpatient and peripartum management of pregnant patients in the setting of FM with consideration given to method of delivery and anesthetic options during delivery....
Open Access DOI:10.23937/2378-3516/1410114
Ramirez-Galindo Maria del Rayo, Isis Areli Lopez-Garcia, Marlenne Perales-Garcia and Fernando Vazquez-Alaniz
Article Type: Case Report | First Published: June 17, 2019
Pleural Effusion is a common medical problem with more than 50 recognized causes including disease local to the pleura or underlying lung, systemic conditions, organ dysfunction, and drugs. The majority of malignant PEf is caused by metastatic disease: Most commonly lung cancer in men and breast cancer in women. However, few germinal teratomas have been reported as the main cause of unilateral PEf....
Open Access DOI:10.23937/2378-3516/1410113
Albert Iruthiaraj Lourdesamy Anthony, Zainal Abidin Ibrahim and Li-Cher Loh
Article Type: Case Report | First Published: June 14, 2019
We report the case of a 62-years-old woman with symptoms of cough and significant loss of weight with radiological findings to support a left lower lobe lung mass. The patient was initially suspected to have metastatic lung malignancy until biopsy results suggested necrotizing granulomatous inflammation. A diagnosis of limited GPA was made when the cytoplasmic antineutrophil cytoplasmic antibodies, (c-ANCA) and antiproteinase-3 antibodies (anti-PR3) was elevated. The patient was treated with com...
Open Access DOI:10.23937/2378-3516/1410112
S Guerrini, M D'Ascanio and A Ricci
Article Type: Case Report | First Published: June 14, 2019
Allergic bronchopulmonary aspergillosis (ABPA) is an immunologically mediated lung disease caused by principally spores of Aspergillus fumigatus especially in asthmatic patients. Various set of diagnostic criteria has been advocated in different studies without a prevailing definition Treatment is based mainly on oral corticosteroids with the possible addition of antifungal agents....
Open Access DOI:10.23937/2378-3516/1410111
Ronly Har-Even Cohn and Israel Amirav
Article Type: Review Article | First Published: June 13, 2019
Primary Ciliary Dyskinesia (PCD) is a rare, genetically heterogeneous and multi-organ disorder, caused by impaired structure and/or function of motile cilia. Impaired ciliary function results in recurrent upper and lower respiratory tract infections (due to ineffective clearance of mucous secretions and inhaled particles). Clinical manifestations of PCD are diverse and include recurrent and chronic infections in the lung, ear, nasal and sinus and involvement of other systems such as cardiovascul...
Open Access DOI:10.23937/2378-3516/1410110
Aniruddha Bhattacharjee, Aye Aye Myat, Shakunthala VT and Rajeev Sharma
Article Type: Research Article | First Published: June 10, 2019
Obesity is rapidly escalating in Malaysia in all age groups. Prevalence of obesity and overweight is increasing in adults and in children in both developed and developing countries. Obesity is a risk factor for many conditions including respiratory disorders regardless of BMI. However, studies investigating pulmonary functions in obese adolescents in Malaysia are few. Hence, the present study was aimed to investigate pulmonary function variables in the adolescent obese students of management and...
Open Access DOI:10.23937/2378-3516/1410109
Juliana Gjerazi, Eritjan Tashi, Irma Tashi and Jul Bushati
Article Type: Research Article | First Published: June 01, 2019
AECOPD have major implications on the quality of life, morbidity and mortality of COPD patients. In addition to their assessment on clinical presentation, which can be variable and difficult to predict, a large number of biomarkers are used. Inflammation increases during exacerbations of COPD and there are changes in systemic markers like CRP, IL 6 and PARC/CC18, as well as the cell structure in sputum and blood. The aim of this study was to investigate the diagnostic and prognostic value of pla...
Open Access DOI:10.23937/2378-3516/1410108
Yasmin Leigh, Christian de Elia, Murali Krishna, La Tanya Taylor, Rachel Morales, Beth Kellogg and Frank Salvatore
Article Type: Research Article | First Published: June 01, 2019
Simulation-based education is thought to be more effective than traditional teaching and recent studies have described its benefits on physician performance in several clinical areas. Despite this, not many studies have researched the benefits of simulation training in teaching mechanical ventilation. With that said, this study was composed to assess the approach of mannequin simulation- based training as a method to provide an interactive learning experience for residents and respiratory therap...
Open Access DOI:10.23937/2378-3516/1410107
Tim W Gilmore, Robert E Walter, Patrick C Hardigan, Clifton F Frilot II and Guy M Nehrenz
Article Type: Original Research Article | First Published: May 16, 2019
There are few recommendations how best to apply certain modes of mechanical ventilation, and the application of Airway Pressure Release Ventilation (APRV) requires strategic implementation of specific inspiratory (I-time) and expiratory times (E-time) and particular mean airway pressures (MAWP), neither of which is standardized. We sought to identify whether an ideal I-time or MAWP could be identified to favor more positive clinical outcomes. A retrospective analysis of archived electronic healt...
Open Access DOI:10.23937/2378-3516/1410106
Francisco Leon-Roman, Alfonso Lopez-Frias Lopez-Jurado, Beatriz Pintado-Cort, Joaquin Asensio-Sanchez, Edwin Mercedes-Noboa, Beatriz Prieto-Gonzalez and Deisy Barrios-Barreto
Article Type: Clinical Case Report | First Published: April 26, 2019
We present the case of an active smoking 44-years-old woman (10 pack/years) diagnosed with lung adenocarcinoma T4N3M1a (stage IV) in the right upper lobe (RUL) in January 2017. She received four cycles of cisplatin-pemetrexed and radiosurgery of brain metastasis. The patient had a body mass index (BMI) of 28, with no other significant comorbidities. In July 2017, tumoral growth with secondary airway stenosis and invasion of the superior vena cava...
Open Access DOI:10.23937/2378-3516/1410105
Ozlem Ceren Gunizi, Gulay Ozbilim and Mualla Ozcan
Article Type: Research Article | First Published: April 26, 2019
Of the 96 patients included in the study, 58 were adenocarcinomas, 30 were squamous cell carcinomas (SCC), and 8 were large cell neuroendocrine carcinomas (LCNEC). While EGFR mutation was detected in 14 (24.1%) of the adenocarcinoma patients, KRAS mutation was detected in 12 (20.6%) patients. BRAF mutation was observed in 1 patient with adenocarcinoma (1.7%). KRAS mutation was observed in only 1 of the SCCs (3.3%). KRAS mutation was observed in 1...
Open Access DOI:10.23937/2378-3516/1410104
Mandeep Hundal, Christian Ghattas, Lori Lyn Price, Peter Lacamera and John Unterborn
Article Type: Original Research Article | First Published: April 03, 2019
Exercise limitation associated with most lung diseases is multifactorial and is due to complex interactions between impaired ventilatory, cardiovascular, and peripheral muscle responses. Cardiopulmonary exercise tests (CPETs) are often required to ascertain the primary cause of exercise limitation particularly in patients with multiple co-morbidities. CPETs are generally offered only at tertiary care medical centers. To evaluate if forced expiratory flow from 25% to 75% of vital capacity (FEF25-...
Open Access DOI:10.23937/2378-3516/1410103
Punam Pahwa, Khalid Amin, Chandima Karunanayake, Sylvia Abonyi and James Dosman
Article Type: ORIGINAL RESEARCH ARTICLE | First Published: February 25, 2019
There is limited knowledge about determinants of chronic bronchitis (CB) among Aboriginal children and adolescents in Canada. The objective of the study was to determine the prevalence and associated risk factors of chronic bronchitis in Aboriginal children (6-11 yrs.) and adolescents (12-19 yrs.). Canadian Aboriginal Peoples Survey (APS)-2012 data were analyzed. Logistic regression analysis with appropriate weight variable to estimate regressio...
Open Access DOI:10.23937/2378-3516/1410102
Joanna V Santeliz
Article Type: Review Article | First Published: February 11, 2019
Pulmonary diseases associated with parasitic infections of the lung are unusual. However, the rise in immunosuppressive conditions such as HIV/AIDS, use of antineoplastic agents and post-transplant medications among others associated with the phenomenon of globalization which entails frequent traveling and migration, has raised their prevalence both in immunocompromised and immunocompetent individuals. Tropical pulmonary eosinophilia (TPE) is a n...
Open Access DOI:10.23937/2378-3516/1410101
Mohsen Soltanifar, Chandima Karunanayake, Dinesh Khadka, Raina Henderson, Niels Konehnck, Sylvia Abonyi, James A Dosman, Punam Pahwa, Mark Fenton and the First Nations Lung Health Project and Saskatchewan Rural Health Research Teams
Article Type: Research Article | First Published: January 19, 2019
The available spirometric lung function equations in Canadian context have been limited to age and height as predictors and Caucasian ethnicity. The plausible equations with other individual predictors and First Nations populations are missing in the current literature. To set an initial investigation in terms of study sample size and simple reference spirometric equations on the association of the set of conventional predictors in companion with two new predictors BMI and ABSI with spirometric ...
Open Access DOI:10.23937/2378-3516/1410100
Enqing Fu and Yan Wang
Article Type: Case Report | First Published: December 24, 2018
Massive hemoptysis (over 200 ml at one go or over 500 ml in twenty-four hours) is considered as a serious case. If the blood cannot be expectorated out from bronchus, sludged blood will form and obstruct the bronchus in a matter of a few minutes. Then an acute respiratory failure would be the immediate result, which might lead to a critical state or death of the patient. The most effective method to rescue patient is to suction off the sludged bl...
Open Access DOI:10.23937/2378-3516/1410099
Robert S Fitzgerald
Article Type: Review Article | First Published: December 12, 2018
Most frequently medical education treats the pulmonary system and the cardiovascular system separately. And this is, indeed, quite understandable because each system's pathologies and their treatments differ in so many ways. However, from another perspective, the physiologist's, both systems are the evolutionary product for capturing oxygen from the external environment and delivering it to the mitochondria in the body's cells for the generation of the energy needed for life's operations. Bound ...
Open Access DOI:10.23937/2378-3516/1410098
Daniel E Fenker, Cameron T McDaniel, Warunya Panmanee, Ralph J Panos, Eric J Sorscher, Carleen Sabusap, John P Clancy and Daniel J Hassett
Article Type: Review Article | First Published: November 29, 2018
Cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) are chronic pulmonary diseases that affect ~70,000 and 251 million individuals worldwide, respectively. Although these two diseases have distinctly different pathophysiologies, both cause chronic respiratory insufficiency that erodes quality of life and causes significant morbidity and eventually death. In both CF and COPD, the respiratory microbiome plays a major contributing ...
Open Access DOI:10.23937/2378-3516/1410097
Jie-Ru Li, Xiu-Hua Gao, Ju-Qiang Han, Wen-Yan Luo and En-Sheng Ji
Article Type: Original Article | First Published: November 23, 2018
Obstructive sleep apnea (OSA) is one of independent dangerous factors for cardiovascular disease including heart failure. Recent studies demonstrated that left ventricular diastolic dysfunction (LVDD) and pentraxin-3 (PTX-3) are early signs for development of heart failure. The objective of our study was to estimate the relation between OSA severity and LVDD and PTX-3. Sixty-six OSA patients and 25 healthy people who underwent polysomnography to ...
Open Access DOI:10.23937/2378-3516/1410096
Article Type: Case Report | First Published: November 19, 2018
The objective of drafting this case report is to delineate the relationship between elephantiasis disease rarely encountered in clinical practice and sleep disordered breathing, to try to understand how this specific condition influences the quality of sleep, to review the mechanisms for Obstructive Sleep Apnea Syndrome which is the most common sleep disordered breathing seen and to underline its importance once again. Lymphedema is a chronic con...
Open Access DOI:10.23937/2378-3516/1410095
Escalier N, Papazian AC, Grimaldi S, Gambetta MX, Spath MB, Lebus J and Salvador Diaz Lobato
Article Type: Case Report | First Published: November 07, 2018
Tracheostomy is a common procedure in long-term ventilated patients and frequent in those with severe stroke. Decannulation not only involves removal of the tracheostomy cannula, but also evaluation of upper airway protection. The predictors of success provide an objective guide to minimize the time of permanence of the same. Currently there are no studies on predictors of decannulation success in neurocritical patients. To analyze clinical and demographic data in a cohort of tracheostomized neu...
Open Access DOI:10.23937/2378-3516/1410094
Francisco X Leon, Beatriz Alba, Alvaro Arribas, Raquel Garcia, Isabel Garcia and Carlos A Quezada
Article Type: Case Report | First Published: October 26, 2018
Coil embolization is an effective and safe treatment of pelvic congestion syndrome. Cases of coil pulmonary migration have been reported after pelvic embolization. However, most cases are usually asymptomatic and do not require specific treatment. We present the first case of pulmonary coil migration after pelvic embolization and concomitant acute pulmonary embolism in a symptomatic patient. The patient was treated with standard anticoagulation a...
Open Access DOI:10.23937/2378-3516/1410093
Belloumi N, Ben Bdira B, Bachouche I, Kacem M, Chermiti Ben Abdallah F and Fenniche S
Article Type: Case Report | First Published: October 25, 2018
Poor compliance to anti-tuberculosis treatment is sometimes related to its adverse effects. By reporting any unusual or severe treatment related accident, we try to enlarge our background in order to manage better any similar case. By writing this paper, up further evidence is provided for a better knowledge and management of ATT adverse events. Here we report a case of leukopenia induced by an anti-tuberculosis oral treatment. Our 43-years-old patient was diagnosed with pleural tuberculosis. B...
Open Access DOI:10.23937/2378-3516/1410092
Murat KARAUZ, A Nedret KOC and Altay ATALAY
Article Type: Original Article | First Published: October 17, 2018
Early diagnosis and treatment of tuberculosis (TB) patients are the most effective ways to protect society from this disease. The objectives of this study were to evaluate the molecular epidemiology of mycobacterial strains by repetitive sequence PCR (rep-PCR) using the DiversiLab System method at Kayseri in Turkey. A total of fifteen clinically sample isolated Mycobacterial strains were identified as M. tuberculosis complex (MTBC) and non-tuberculous mycobacteria (NTM) by the rep-PCR method (bi...
Open Access DOI:10.23937/2378-3516/1410091
Sohini Basu, Rishna Dalui, Anindita Singha Roy and Amit Bandyopadhyay
Article Type: Original Article | First Published: October 13, 2018
Assessment of lung function is an indispensable tool for determination of the health status in case of the athletes. Present study focused on evaluating the lung function parameters for the state-level male basketball players and male volleyball players of West Bengal, India apart from comparing the data with their age-matched healthy, sedentary male counterparts. Fitness of an individual may be adjudged by employing a battery of physiological test manoeuvres, and lung function test is one such ...
Open Access DOI:10.23937/2378-3516/1410090
Dmitriy Kogan and Kavita Ratarasarn
Article Type: Case Report | First Published: October 12, 2018
Narcolepsy is associated with high prevalence of comorbid sleep disorders. Overlap in symptoms of different disorders may confound management. Sleep Medicine practitioners need to be vigilant for presence or new development of comorbid conditions to provide effective and comprehensive care. We present a patient with Narcolepsy Type 2 who developed worsening hypersomnolence due to new onset Obstructive Sleep Apnea (OSA). Treatment of OSA resulted in improvement of hypersomnolence without requirin...
Open Access DOI:10.23937/2378-3516/1410089
Sneh Arora, Rashi Jain, Anant Mohan, Pawan Tiwari and Randeep Guleria
Article Type: Original Article | First Published: October 12, 2018
Dyslipidemia is considered as the major risk factor for cardiovascular disease (CVD) and may contribute to the higher mortality in chronic obstructive pulmonary disease (COPD). However, the prevalence and consequences of dyslipidemia in COPD is still unclear. We studied comprehensive lipid profile panel including serum total cholesterol (TC), triglyceride (TG), low density lipoproteins (LDL), very low-density lipoproteins (VLDL) and high-density ...
Open Access DOI:10.23937/2378-3516/1410088
Maoua M, Gaddour A, Rouis H, Kacem I, Guedri S, Aissa S, Ghammem M, Boughattas W, Brahem A, Kalboussi H, El Maalel O, Chatti S and Mrizak N
Article Type: Original Article | First Published: October 12, 2018
The association between occupational asthma (OA) and occupational allergic rhinitis (OAR) is often described in the literature supporting the concept of "United airways disease" based on a parallel significant reaction of the nose and lungs after challenges with occupational agents and involving several occupational, host-related and environmental factors and thus exacerbating the medical and socio-economic impact of the OR. In Tunisia, only limited studies were carried out to explore associatio...
Open Access DOI:10.23937/2378-3516/1410087
Dandan A, Dettenmeier P, Chang J and Espiritu JRD
Article Type: Original Article | First Published: August 23, 2018
Since the supine position worsens obstructive sleep apnea (OSA) by promoting upper airway collapse, patients may avoid supine sleep in order to mitigate its effects. However, the avoidance of supine sleep during polysomnography (PSG) may result in a missed diagnosis of OSA. This study aims to examine the association between the presence/absence of supine sleep and the diagnosis of OSA during PSG....
Open Access DOI:10.23937/2378-3516/1410086
Fatih Uzer and Hulya Dirol
Article Type: Case Report | First Published: August 23, 2018
Amyloidosis is characterized by extra-cellular deposition of an insoluble fibrillary protein, amyloid in organs and tissues. It is classified as either primary or secondary based on the presence of concomitant diseases, ranging from chronic infection or inflammation to malignancy and as limited or systemic based on the extent of organ invasion. The clinical and radiological manifestations of amyloidosis are varrious and often nonspecific, making ...
Open Access DOI:10.23937/2378-3516/1410085
Hoorak Poorzand, Fariba Rezaeetalab, Masoud Sadeghipour Marvy, Aida Javanbakht, Monavar Afzalaghaei and Majid Jalalyazdi
Article Type: Research Article | First Published: August 17, 2018
Inflammation has an important role in chronic obstructive pulmonary diseases (COPD) and statins are believed to have anti-inflammatory effects beyond low-density lipoprotein cholesterol reduction. This study aimed to assess the effect of statin on the function of the right ventricle and inflammatory markers in COPD patients....
Open Access DOI:10.23937/2378-3516/1410084
Ricardo Peris Sanchez, Estrella Fernandez-Fabrellas, Gustavo Juan Samper, Maria Luisa Domingo Montanana and Lidia Navarro Vilar
Article Type: Original Article | First Published: August 16, 2018
High-resolution computed tomography (HRCT) is an essential technique for the diagnosis and follow-up of idiopathic pulmonary fibrosis (IPF), but it is not routinely used to evaluate severity. A semi-quantitative HRCT score was developed to determine its relation with physiologic variables, to assess severity and fibrosis progression, and to establish prognostic factors....
Open Access DOI:10.23937/2378-3516/1410083
Chiyo Yano, Masaki Tominaga, Keisuke Miwa, Yoshiko Naito, Yuki Sakazaki, Takuma Koga, Masaki Okamoto, Tomotaka Kawayama, Tomoaki Hoshino, Reiji Muto, Koichi Ohshima and Masanori Hisaoka
Article Type: Case Report | First Published: July 26, 2018
A 28-year-old Japanese woman complained of right chest pain, fever, and cough. Chest radiography revealed consolidation in her right lower lobe with a pleural effusion. She was diagnosed with pneumonia and treated with antibiotics, but her condition did not improve. She was referred to our hospital for evaluation. Contrast-enhanced computed tomography (CT) demonstrated a large saddle filling defect extending into the right pulmonary artery as wel...
Open Access DOI:10.23937/2378-3516/1410082
Vipula R Bataduwaarachchi, Jayani Jayawardhana, Champa Weerasinghe, Aflah Sadikeen, Roshana Constantine and Kirthi Gunasekara
Article Type: Case Report | First Published: July 14, 2018
A young woman presented with an asymptomatic recurrent right sided pleural effusion. Pleural fluid full report showed neutrophilic and haemorrhagic effusion. Adenosine deaminase level in the pleural fluid was elevated and the Mantoux test was positive. Microbiological diagnosis was negative, and she was started on anti-tuberculous therapy on clinical grounds for extrapulmonary tuberculosis. Diagnostic Thoracoscopy revealed characteristic appearan...
Open Access DOI:10.23937/2378-3516/1410081
D Lukoye, D Okello, S Namatovu, A SSebagereka, K Mutesasira, Mabumba Eldad, M Nandala and P Suarez
Article Type: Research Article | First Published: July 13, 2018
Tuberculosis remains the greatest killer globally. Uganda, one of the highest TB burden countries has a rapidly growing private medical sector. Although a large proportion of patients first seek care from the private sector, there is very little if any literature about participation of private independent laboratories in diagnosis of TB. We aimed at assessing this and the extent to which diagnosed TB patients are linked to care....
Open Access DOI:10.23937/2378-3516/1410080
Ammar Awad Elshiekh Elmajzoup, Abdel Rouf Ahmed Abbas Elbadawi and Faiz Abel Wahab Mohammed
Article Type: Original Article | First Published: June 14, 2018
The present study determined the prevalence of work-induced respiratory symptoms among Sudanese extrusion workers in an aluminum (Al) extrusion plant where the health effects of exposure duration, S-Al, and U-Al concentrations were evaluated. A total of 109 workers were enrolled in our study. Ambient Al fumes was estimated using a flame atomic absorption spectrophotometer (Varian, Spectr AA-250)....
Open Access DOI:10.23937/2378-3516/1410079
Abraham O Kuranga, Andrea M Eubank and Mark R Bowling
Article Type: Review Article | First Published: May 14, 2018
Fibrosing Mediastinitis (FM) is a rare but increasingly recognized complication that has been mainly associated with chronic pulmonary histoplasmosis, granulomatous diseases, infections and autoimmune processes. Symptoms vary depending on compromised structures, mainly structures within the mediastinum. This review will focus on the etiology, clinical presentation and management of fibrosing mediastinitis based on multiple case series published t...
Open Access DOI:10.23937/2378-3516/1410078
YT Liew, KN Lorna Ting, AB Zulkiflee and N Prepageran
Article Type: Case Report | First Published: April 26, 2018
Pyogenic granuloma, or lobular capillary haemangioma is common in skin and mucosal surface such as oral cavity. It hardly occurs in tracheal mucosal, and even more rare to cause life threatening tracheal obstruction. Surgical excision is the mainstay of treatment with multidisciplinary support....
Open Access DOI:10.23937/2378-3516/1410077
Nicki Barker, Matt Willox and Heather Elphick
Article Type: Review Article | First Published: March 23, 2018
Long Term Non-Invasive Ventilation (NIV) is increasingly common and is benefitting children with a wider range of conditions. It improves quality of life and life expectancy and reduces hospital admissions and length of stay. Children are at risk however of adverse effects caused by NIV interfaces such as skin injury, facial flattening and eye problems....
Open Access DOI:10.23937/2378-3516/1410076
Sravanthi Nandavaram and Dragos Manta
Article Type: Case Report | First Published: March 17, 2018
Lipoid pneumonia is an uncommon non-infectious condition that results from the accumulation of lipids of animal, vegetable or mineral origin, in the lungs. Most often it is a result of aspiration from altered swallowing or cough mechanism. Children with palatal abnormalities debilitated older adults or adults with neurological or gastrointestinal disorders are commonly affected....
Open Access DOI:10.23937/2378-3516/1410075
Anna Duffy and Avinash Aujayeb
Article Type: Review Article | First Published: November 24, 2017
We are an established pleural centre offering medical thoracoscopy and indwelling pleural catheters. Our infection rates with prophylactic antibiotics were lower than the national average and given the era of antibiotic stewardship and lack of evidence to support the administration, we stopped giving them....
Open Access DOI:10.23937/2378-3516/1410074
Kevin Swiatek, Rachel Guthrie, John O Elliott and Kim Jordan
Article Type: Research Article | First Published: August 11, 2017
Periprocedural management of aspirin and clopidogrel, antiplatelet agents, for Endobronchial Ultrasound with Transbronchial Needle Aspiration (EBUS-TBNA) remains unclear. Discontinuation of antiplatelet therapy has been questioned given the low risk of hemorrhagic complications reported with this procedure....
Open Access DOI:10.23937/2378-3516/1410073
Kevin G Lazo, Joanna B Eldredge, Anne Press and Bushra A Mina
Article Type: Review Article | First Published: July 14, 2017
Respiratory complaints are common symptoms in pregnancy, and it is important to delineate whether the causative factor is cardiac, pulmonary, or physiologic in origin. The pathophysiology of Sickle Cell Disease (SCD) can further complicate the differential diagnosis....
Open Access DOI:10.23937/2378-3516/1410072
Rachel D Quick, Kathryn Merkel, Don K Murphey, Marisol Fernandez and Sarmistha B Hauger
Article Type: Original Article | First Published: June 22, 2017
This is a report of pediatric patients hospitalized with Respiratory Syncytial Virus Infection (RSV) during the season prior to, and 2 seasons following the 2014 palivizumab prophylaxis guidance release. The primary aim was to determine the effect of the 2014 guidance on children no longer considered eligible for prophylaxis....
Open Access DOI:10.23937/2378-3516/1410071
Francisco X Leon-Roman Ismael Carrillo-Martin, Gema Fernandez-Plana and Salvador Diaz-Lobato
Article Type: Case Report | First Published: June 12, 2017
Crimean-Congo Haemorrhagic Fever (CCHF) is a lethal vector-borne viral infection produced by a Nairo virus, a genus of the Bunyan viridae family. Crimean-Congo Haemorrhagic Fever Virus (CCHFV) is a single-stranded RNA virus with three segments (large, medium, and small), two envelope proteins (Gn and Gc) and an RNA-dependent RNA polymerase....
Open Access DOI:10.23937/2378-3516/1410070
Aujayeb A and Miller J
Article Type: Case Report | First Published: May 12, 2017
A 74-year-old with burnt out autoimmune hepatitis, portal hypertension with thrombocytopenia, oesophageal varices and previous hepatic encephalopathy has presented with a recurrence of a left sided pleural effusion. She was very breathless at rest and therapeutic aspiration of 1.1 litres of straw coloured fluid has good symptomatic benefit....
Open Access DOI:10.23937/2378-3516/1410069
Pankaj Mathur, Vinod Namana, Sushilkumar S Gupta, Barbara Berger and Elliott Bondi
Article Type: Clinical Image | First Published: April 13, 2017
A 31-year-old male presented with complaints of a mild non-productive cough for 2 months. He had no history of smoking, fever, chills, rigors, weight loss, dyspnea, chest pain and hemoptysis. There was no history of exposure to occupational hazards or medications use. He was hemodynamically stable and had no significant findings on physical examination....
Open Access DOI:10.23937/2378-3516/1410068
William Li, Bhaskara Madhira and Michael Kosters
Article Type: Case Report | First Published: March 09, 2017
Endemic infections produce a spectrum of illness ranging from being subclinical to severe progressive disseminated diseases with Immuno compromised individuals being increased risk. In those with an apparently non-improving infection, a simultaneously occurring second infectious source should be considered....
Open Access DOI:10.23937/2378-3516/1410067
C Walker, J Mackenzie, J Aust, J Port, D Cooper, S Parker, S Bourke, J Miller, M Weatherhead and A Aujayeb
Article Type: Research Article | First Published: February 20, 2017
All pleural aspirations done between January 1st 2014 and December 31st 2015 were analyzed for fluid biochemistry, microbe, cytology and final diagnoses (n = 264). Light's criteria were applied wherever possible. The fluid biochemistry, microbiology and cytology results were assimilated from the local electronic results system. The patient diagnosis was taken from clinic letters electronically uploaded to another system called SingleView. Local g...
Open Access DOI:10.23937/2378-3516/1410066
Guang-Qian Xiao and Sapna Patel
Article Type: Case Report | First Published: February 10, 2017
Seromucinous hamartoma is an extremely rare entity that has been described in the sinonasal cavity and nasopharynx. We here present a case of seromucinous hamartoma manifesting as an obstructive endobronchial mass in a 65-year-old male and active smoker, who presented with dyspnea upon prolonged exertion and atelectasis....
Open Access DOI:10.23937/2378-3516/1410065
Basavaraj Ashwin, Segal Leopoldo, Samuels Jonathan, Feintuch Jeremy, Feintuch Joshua, Alter Kevin, Moffson Daniella, Scott Adrienne, Addrizzo-Harris Doreen, Liu Mengling and Kamelhar David
Article Type: Original Research | First Published: January 21, 2017
Antibiotic therapy against non-tuberculous mycobacteria (NTM) is prolonged and can be associated with toxicity. We sought to evaluate whether chest physical therapy (PT) was associated with clinical improvement in patients with NTM not receiving anti-mycobacterial pharmacotherapy. A retrospective review of 77 subjects that were followed from June 2006 to September 2014 was performed. Baseline time point was defined as the first positive sputum cu...
Open Access DOI:10.23937/2378-3516/1410064
Gumani D, Newmarch William, Puopolo Angelica and Casserly Brian
Article Type: Review Article | First Published: December 12, 2016
Inhalers are a commonly used device to deliver medication to individuals with airway disease. With correct use, inhalers are very effective at providing quick and effective symptomatic relief within the lung, avoiding high levels of systemic exposure. These pharmacokinetic characteristics widen the therapeutic index, thus allowing for maximal therapeutic benefit with minimal adverse effects. However, this theoretical advantage is somewhat attenua...
Open Access DOI:10.23937/2378-3516/1410063
Jeena Jacob and Matthew Crotty
Article Type: Editorial | First Published: November 28, 2016
The 2005 guidelines recommended classification of patients based on their risk of infection by resistant bacterial pathogens. The now abandoned HCAP entity included any patient hospitalized in an acute care hospital for two or more days within 90 days of the infection; residing in a nursing home or long-term care facility; exposed to recent intravenous antibiotic-therapy, chemotherapy, or wound care within the past 30 days of the current infectio...
Open Access DOI:10.23937/2378-3516/1410062
Michael P Phelan, Jonathan M Glauser, Fredric M Hustey, Motunrayo Mobolaji-Lawal and Stephen W Meldon
Article Type: Original Research | First Published: November 21, 2016
We analyzed an emergency department (ED) performance improvement (PI) database from an airway registry that was developed to monitor the care of patients undergoing endotracheal intubation in prehospital settings or in the study site ED. PI initiatives included implementation of electronic health record (EHR) documentation templates for ETT placement/confirmation, an online educational module, and performance feedback....
Open Access DOI:10.23937/2378-3516/1410061
Valmore Bermudez, Edgar Miquilena, Juan Salazar, Robys Gonzalez, Luis Carlos Olivar, Maria Jose Calvo, Roberto Anez, Jose R Rivas-Rios and Joselyn Rojas
Article Type: Research Article | First Published: November 06, 2016
A descriptive, cross-sectional research study, framed in the study Prevalence of Metabolic Syndrome in Maracaibo city conformed by 2,212 adults of both genders; based on the medical information the individuals were classified in smokers, non-smokers and former smokers. Quantitative variables were expressed as medians and qualitative variables as absolute and relative frequencies, using χ2 for significance and Z test for difference of proport...
Open Access DOI:10.23937/2378-3516/1410060
Hiromasa Arai, Michihiko Tajiri, Kohei Ando, Koji Okudela, Tae Iwasawa and Munetaka Masuda
Article Type: Case Report | First Published: October 17, 2016
A 63-year-old Japanese male suffering from interstitial pneumonia underwent computed tomography (CT) guided tumor localization using a hook wire and a suture system for a small pulmonary nodule suspected of being lung carcinoma. He underwent subsequent video-assisted thoracoscopic surgery. The cut suture connecting to the metal head of the hook wire in the lung parenchyma was visible at the beginning of the procedure. During the surgery, the sutu...
Open Access DOI:10.23937/2378-3516/1410059
Tomoo Kishaba, Hiroaki Nagano, Yuichiro Nei, Shin Yamashiro and Harumi Ito
Article Type: Original Article | First Published: October 03, 2016
Background: Polymyositis (PM) and dermatomyositis (DM) often have interstitial lung disease (ILD) and progression of ILD is important cause of death. Objectives: This study is conducted to clarify the important clinical, radiological factors of PM/DM ILD patients. Methods: We reviewed medical records, pulmonary function test (PFT), chest high-resolution computed tomography (HRCT) findings from January 1, 2001 to December 31, 2014 retrospectively ...
Open Access DOI:10.23937/2378-3516/1410058
Ryo Matsunuma, Kazumasa Kase, Nobuhiro Asai, Satoshi Watanabe, Yuko Waseda, Norihiro Kaneko, Masahiro Aoshima, Masaki Fujimura and Kazuo Kasahara
Article Type: Original Article | First Published: October 01, 2016
Background: Patients with thoracic empyema occasionally require chest tubes for drainage. Several studies have reported that smaller chest tubes are effective and cause fewer complications. The aim of this study was to investigate the outcomes of patients with empyema who underwent drainage using a smaller-size chest tube. Methods: We retrospectively reviewed all patients at 2 institutions with thoracic empyema. We performed both univariate and m...
Open Access DOI:10.23937/2378-3516/1410057
Yuji Ohtsuki, Shinji Fujioka, Masashi Uomoto, Yasuki Hachisuka, Masataka Korenaga, Atsushi Kurabayashi, Ichiro Murakami and Mutsuo Furihata
Article Type: Case Report | First Published: September 19, 2016
A native Japanese woman in her 60's complained of hemosputum and had an irregular nodular shadow in her chest radiograph. The nodule was surgically removed, and the histopathological findings of the pulmonary lesion showed a necrotizing granuloma with central irregular geographic necrosis associated with parasite eggs. The results of the enzyme-linked immunosorbent assay of her serum confirmed Paragonimus westermani (Pw) infection as the cause, o...
Open Access DOI:10.23937/2378-3516/1410056
Yusuf Kayar, Nuket Bayram Kayar, Nurcan Unver and Iskender Ekinci
Article Type: Case Report | First Published: September 02, 2016
Sarcoidosis is a systemic granulomatous disorder of unknown causes. Haematological manifestations in sarcoidosis are uncommon and may include haemolytic anemia, leukopenia, eosinophilia and peripheral lymphopenia, but severe thrombocytopenia is rare. Causes of thrombocytopenia in sarcoidosis were identified a few mechanisms. There are no current guidelines concerning the treatment of thrombocytopenia in sarcoidosis. However, in emergency situatio...
Open Access DOI:10.23937/2378-3516/1410055
Muhammad Ali Karim, Muhammad Josheel Naveed, Amir Hussein and Abdulmajid Ali
Article Type: Original Article | First Published: September 01, 2016
Purpose: Bariatric surgery is an established treatment of morbid obesity and effectively controls symptoms of OSAHS. The aim of this study was to evaluate impact of bariatric surgery on OSAHS. Methods: Validated Epworth Sleepiness Score (ESS) and STOP-Bang questionnaires were used to assess the impact of bariatric surgery on OSAHS in morbidly obese patient's undergone bariatric surgery from May 2008 to December 2011. Change in ESS, STOP-Bang scor...
Open Access DOI:10.23937/2378-3516/1410054
Ping Zeng and Jian Yang
Article Type: Review Article | First Published: August 25, 2016
Myocardial infarction is usually recognized as the final stage of coronary artery stenosis or occlusion in response to coronary atherosclerosis and thrombosis involving dysfunction and activation of resident vascular cells as well as the release of t-PA. As a member of family proteins for deacetylation of core histones in eukaryotic cells, Histone deacetylases are implicated in various biological processes....
Open Access DOI:10.23937/2378-3516/1410053
Marta Afonso Nogueira, Luisa Moura Branco, Ana Agapito, Ana Galrinho, Alexandra Borba, Ruben Ramos, Duarte Cacela and Rui Cruz Ferreira
Article Type: Original Article | First Published: August 23, 2016
Several echocardiographic parameters study right ventricular (RV) function, which has a prognostic impact on pulmonary hypertension (PH). Our goal was to evaluate the correlation between known prognostic markers and standard, as well as advanced echocardiographic parameters, including Tissue Doppler (TDI), strain imaging and three-dimensional (3D) echocardiography....
Open Access DOI:10.23937/2378-3516/1410052
Carmen Carrasco Cubero and Chamizo Carmona
Article Type: Case Report | First Published: August 22, 2016
Henoch-Schonlein purpura (HSP) is a systemic vasculitis that affects small-sized vessels, characterized by non-thrombocytopenic purpura, along with other clinical manifestations such as arthritis, abdominal pain, gastrointestinal bleeding and renal disease. Although the presence of subclinical alterations of pulmonary function has been noticed, the appearance of diffuse alveolar hemorrhage (DAH) is a rather an unusual symptom. We report a case of...
Open Access DOI:10.23937/2378-3516/1410051
Ming-Shian Lu, Tsung-Ming Yang, Cheng-Chih Chang, Chien-Chao Lin, Yao-Kuang Huang and Ying-Huang Tsai
Article Type: Original Article | First Published: August 16, 2016
We conducted a one-year prospective observational study of adult post-surgical patients admitted to the surgical intensive care unit and mechanically ventilated for more than 24 hours. Forced cough peak expiratory flow (FCPEF) was assessed by using a digital peak flow meter placed in-line with the endotracheal before extubation after passing previously a spontaneous breathing trial....
Open Access DOI:10.23937/2378-3516/1410050
Georges Al-Helou, Sripooja Satya, Brian Senisi, Robert Maximos and Jalil Ahari
Article Type: Case Report | First Published: July 11, 2016
A 63-year-old man known to have human immune-deficiency viral (HIV) infection was referred for evaluation following three episodes of left upper lobe pneumonia. He was well controlled on his anti-retroviral medications. Physical exam showed left upper lobe wheezing. No evidence of obstruction could be seen on chest X-ray or computed tomography (CT). Bronchoscopy was done and showed an obstructing lesion that was biopsied then ablated. It was foun...
Open Access DOI:10.23937/2378-3516/1410049
Shin Matsuoka, Tsuneo Yamashiro, Shoichiro Matsushita, Atsuko Fujikawa, Kunihiro Yagihashi and Yasuo Nakajima
Article Type: Original Article | First Published: June 30, 2016
Objective quantitative evaluation for the extent of fibrosis has been introduced using CT densitometry in patients with interstitial lung diseases, however, there have been no definitive attenuation cut-off values to evaluate the extent of ground-glass opacity and fibrosis separately. This study was conducted to investigate the relationships between quantitative CT measurements using different attenuation ranges and visual CT scores, and to deter...
Open Access DOI:10.23937/2378-3516/1410048
Su-Lun Hwang, Yu-Ching Lin, Su-Er Guo, Miao-Ching Chi, Chiang-Ting Chou and Chieh-Mo Lin
Article Type: Original Research Article | First Published: May 23, 2016
Objective: Chronic obstructive pulmonary disease (COPD) poses a substantial burden of illness in the Asia-Pacific region, as it does worldwide. However large-scale and community-based epidemiology studies of COPD in Taiwan are limited. This paper conducted a population-based study to investigate the prevalence of COPD in southwestern Taiwan. Methods: Data were conducted using a subset of medical claims data from the National Health Insurance Rese...
Open Access DOI:10.23937/2378-3516/1410047
Hanaa Shafiek, Nashwa Abd-elwahab, Manal Baddour, Akram Degady, Mohamed El-hoffy and Yehia Khalil
Article Type: Original Research Article | First Published: May 09, 2016
Objective: To assess the value of interleukin-6 (IL-6), interleukin-8 (IL-8) and C-reactive protein (CRP) in predicting the outcome of acute respiratory failure (ARF) on top of COPD. Patients and methods: Serum samples were collected from 33 COPD patients presented with ARF for IL-6, IL-8, and CRP analysis on admission, after 72 hours and after 14 days. Sputum samples were taken for microbiological evaluation. ...
Open Access DOI:10.23937/2378-3516/1410046
Haris Hakeem, Ghulam Fareed, Muhammad Irfan and Saulat Fatmi
Article Type: Case Report | First Published: April 22, 2016
Echinococcosis or hydatid cyst disease is among the oldest diseases known to man. Common presentations include involvement of liver and lungs. Hydatid cyst in diaphragm without hepatic involvement is rare and less than 100 cases are reported in literature. We are describing a case of a young female who presented with cough anddyspnea secondary to large cysts that appeared to involve the right lung and spleen on initial imaging studies. Peroperati...
Open Access DOI:10.23937/2378-3516/1410045
Toprak S and Kalkan EA
Article Type: Case Report | First Published: April 21, 2016
This case report presents an acute and chronic inflammation process at the same time and resulted in death following exposure to chlorine gas. A 65-years-old woman died shortly after cleaning her bathroom with a mixture of various chemicals including bleach and an acid containing product. She was declared dead when she arrives to hospital. She is a non-smoker and has no significant medical history other than asthma. Toxicological analysis showed ...
Open Access DOI:10.23937/2378-3516/1410044
Christopher M. Blanchette, Melissa Roberts, Hans Petersen and Anne Fuhlbrigge
Article Type: Original Research | First Published: April 19, 2016
A prevalent cohort of Medicare beneficiaries aged 65+ with COPD (chronic bronchitis, emphysema, bronchiectasis, chronic airway obstruction) was constructed from a 5% sample of Medicare beneficiaries. Existence of depression/anxiety was identified via healthcare services or prescription drug claims. Baseline characteristics were assessed (1/1/2006-6/31/2006) and patients followed from first depression/anxiety claim until 12/31/2007 for all-cause a...
Open Access DOI:10.23937/2378-3516/1410043
Sezgi Sahin Duyar, Yalcin Solak, Dilek Tekis, Jale Karakaya, Ferit Kuscu and Asuman Erarslan
Article Type: Original Article | First Published: March 31, 2016
Neutrophil to lymphocyte ratio(NLR) and platalet to lymphocyte ratio (PLR) are recently defined novel inflammatory markers which are readily available. Their prognostic signifigance has been shown for a number of inflammatory diseases. A recent study evaluated the role of NLR in patients with chronic obstructive pulmonary disease(COPD). Thus, we aimed to investigate the relations between NLR, PLR and severity of COPD in male patients who had stab...
Open Access DOI:10.23937/2378-3516/1410042
Anica Jokic, Gordana Mumovic, Maja Buljcik-Cupic and Olga Popov-Dragin
Article Type: Review Article | First Published: March 17, 2016
Increasing evidence in the literature indicates that respiratory allergies are often a hidden contributory factor in vocal dysfunction. Although the precise allergic pathophysiological process within the vocal folds is not yet determined, modern understanding suggests that allergic changes in the lining of the larynx are an integral part of a systemic respiratory allergic reaction....
Open Access DOI:10.23937/2378-3516/1410041
Sidra Anwar and Amy Case
Article Type: Review Article | First Published: March 15, 2016
Mr. M was a 74-year-old male Korean War veteran who presented to the hospital with an acute exacerbation of his Chronic Obstructive Pulmonary Disease (COPD). The patient had a 50 pack-year history of smoking and continued to smoke one-and-a-half packs of cigarettes per day. He was frail with barrel chest and pursed lip breathing, tachypnea, and dyspneic at rest. He was on Albuterol, Ipratropium bromide, and Fluticasone propionate, in addition to ...
Open Access DOI:10.23937/2378-3516/1410040
Som N Chalise, Craig Brown and Mark R Bowling
Article Type: Case Report | First Published: February 22, 2016
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has many potential complications though most occur infrequently. We encountered a case in which the EBUS needle broke during TBNA. The patient was a 65 year old man who underwent EBUS-TBNA for right paratracheal lymphadenopathy. During the procedure, the TBNA needle was found to be broken. We were able to completely recover it without any complications to the patient or ...
Open Access DOI:10.23937/2378-3516/1410038
Hirofumi Matsuoka, Sachie Kume, Sayaka Inoue, Nao Oda, Yusuke Matsumoto, Koji Tamai, Nobuhiko Okada, Akiko Otsuka, Yasuko Koma, Kenji Kaihotsu, Harukazu Yoshimatsu, Masanori Iwahashi, Toru Miyajima and Yujiro Suzuki
Article Type: Original Research | First Published: February 08, 2016
The prevalence and mortality of chronic obstructive pulmonary disease (COPD) is expected to increase, not only in Japan but also worldwide. The prevalence of COPD is estimated to be 8.6% in Japan; however, it is reported that many COPD patients remain undiagnosed and untreated. Because COPD is a treatable and preventable disease, early diagnosis and management are important....
Open Access DOI:10.23937/2378-3516/1410039
R Steven Pappas, Mary M Halstead and Clifford H Watson
Article Type: Research Article | First Published: February 11, 2016
Scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDS) supplies information that is complementary to those data traditionally obtained using inductively coupled plasma-mass spectrometry for analysis of inorganic tobacco and tobacco smoke constituents. The SEM-EDS approach was used to identify select inorganic constituents of mainstream cigarette smoke "tar". The nature of SEM-EDS instrumentation makes it an ideal choice ...
Open Access DOI:10.23937/2378-3516/1410037
Marie Christy Sharafine Stephen, Eswaran Venkata Raman, Gnanam Aram and Anitha Kumar
Article Type: Case Report | First Published: February 02, 2016
Pompe disease is a rare and progressive lysosomal storage disorder, of autosomal recessive inheritance. Disease onset and progression range from early infantile onset which is fatal and rapidly progressive to the late onset formthatis slowly progressive, but leads to severe respiratory dysfunction and significant morbidity. Besides, scoliosis and other spine deformities cause substantial workload on the already compromised ventilation. This has a...
Open Access DOI:10.23937/2378-3516/1410036
Li Wang, Meenakshi Bansal and Guang-Qian Xiao
Article Type: Case Report | First Published: December 22, 2015
Endobronchial lipomas, usually found in the obese and in smokers, can cause patients significant distress with chronic cough, chest pain, dyspnea, and increased infection risk. Here we present a case of a 61 year-old obese, never-smoker gentleman who initially presented with chronic productive cough, hemoptysis, chills and night sweats; and was later found to have a right upper lobe lung parenchymal lesion. Biopsy demonstrated a picture consisten...
Open Access DOI:10.23937/2378-3516/1410035
Lucinda England, Joseph G. Lisko and R. Steven Pappas
Article Type: Editorial | First Published: November 01, 2015
The use of electronic nicotine delivery systems such as electronic cigarettes has increased considerably in recent years among youth and adults. While the majority of adult electronic cigarette users are current conventional cigarette smokers, an increasing number of adolescents who have not previously smoked are using use electronic cigarettes. Despite these trends, many health care providers report feeling uninformed about the health risks asso...
Open Access DOI:10.23937/2378-3516/1410034
Maria Jose Soler-Sempere, Nuria Vicente-Ibarra and Laura Heredia-Oliva
Article Type: Case Report | First Published: October 31, 2015
Biliothorax and pleurobiliary fistula are rare complications secondary to biliary tree diseases. We report the case of a patient with left massive pleural effusion secondary to biliothorax without fistula or ascites. To our knowledge, this is the first case to be described with left side biliothorax....
Open Access DOI:10.23937/2378-3516/1410033
Astrud R Tuck,Luke E Grzeskowiak, Annette Osei-Kumah, Zarqa Saif, Suzanne M Edwards, Andrew Tai, Susan L Prescott, MeriTulic, Richard Saffery and Vicki L Clifton
Article Type: Research Article | First Published: October 29, 2015
The prevalence of allergic disease has risen significantly during recent years. A major component of the susceptibility to allergic disease is determined in prenatal life, when the placenta plays a central role in fetal growth and development. In this study, we aimed to identify the patterns of gene expression in the placenta that may program early immune function to increase susceptibility to allergy....
Open Access DOI:10.23937/2378-3516/1410032
Nikolaos Panagiotopoulos, Mohamed. A Gulamhussein, Davide Patrini, Rajeev Shukla, Martin Lees, Martin Hayward, Shyamsunder Kolvekar and David Lawrence
Article Type: Case Report | First Published: October 28, 2015
Iatrogenic tracheal rupture following intubation is a rare, but potentially lethal complication. Usually patients present with the classical symptoms of mediastinal subcutaneous emphysema and respiratory distress. However, the timing or the onset of these symptoms is quite variable and differs between patients....
Open Access DOI:10.23937/2378-3516/1410031
Rui Fan, Daniel Penny and Yuxin Fan
Article Type: Review Article | First Published: October 23, 2015
Pulmonary arterial hypertension (PAH) is a devastating disease with significantly reduced survival. To date, no tested therapies have demonstrated an ability to reverse or cure the disease. The etiology of PAH is heterogeneous and incompletely understood. Genetics plays an important role in idiopathic and heritable PAH. Many germline gene mutations have been described as promoters of PAH and include mutations in the gene coding BMPR2, which has b...
Open Access DOI:10.23937/2378-3516/1410030
Caitlin Naureckas, Jonathan Movson and E Jane Carter
Article Type: Case Report | First Published: October 20, 2015
A 21-year-old Guatemalan male presented with six months of headaches and neck pain. MRI of the cervical spine demonstrated multiple inflammatory processes, both within the paraspinal soft tissue as well as within the bone itself, including the appearance of total destruction of C1. Microbiologic confirmation of Mycobacterium tuberculosis was made by fine needle aspiration. The patient was treated medically with appropriate anti-tuberculosis thera...
Open Access DOI:10.23937/2378-3516/1410029
Dorte Jessing Agerby Hanskov, Charlotte Brauer, Nina Breinegaard and Lilli Kirkeskov
Article Type: Original Research Article | First Published: October 2, 2015
This study investigated whether Danish construction workers had an increased prevalence of chronic obstructive pulmonary disease (COPD) or affected lung function and if the prevalence differed between types of jobs within construction....
Open Access DOI:10.23937/2378-3516/1410028
Shlomo Merchavy and Nadav Bartal
Article Type: Case Report | First Published: September 16, 2015
Laryngocele is rare condition in which dilation of the laryngeal saccule that extends upward the false vocal cord, is filled with air, and is in communicating with the laryngeal lumen1. It can presents as neck mass or as cystic lesion in the neck. Awareness regarding this rare entity can help the physician in making the correct diagnosis....
Open Access DOI:10.23937/2378-3516/1410027
Mazen S. Bader, Kassem Abouchehade, Annie A. Brooks, Yanqing Yi
Article Type: Research Article | First Published: September 10, 2015
In patients with diabetes mellitus (DM), community-acquired pneumonia (CAP) is associated with significant morbidity and mortality. The primary objective of the study was to describe the clinical outcomes and risk factors for moderate-severe CAP in hospitalized patients with DM. Methods: We conducted a retrospective cohort study of 156 hospitalized patients with DM and moderate-severe CAP at two tertiary medical centers....
Open Access DOI:10.23937/2378-3516/1410026
Philip M Muthoka, Dismas Ongore and Mary Kinoti
Article Type: Research Article | First Published: September 07, 2015
ILI infections are infections of the human respiratory tract. They are caused by various viruses including corona viruses, adeno-viruses, influenza virus types A, B and C, among others (CDC- US, 2005). When these infections are circulating within the community, patients with ILI infections who have both cough and fever within 48 hours of symptom onset are likely to have influenza (A or B) infections. In Kenya, these infections cause significant m...
Open Access DOI:10.23937/2378-3516/1410025
Ravi Kr. Gupta, Bhavnesh Kumar, Deepa Bisht, Kiran Katoch, Kalyan Mitra and Ranjana Srivastava
Article Type: Case Report | First Published: August 03, 2015
The major obstacle in TB eradication is attributed to the dormant state of the TB bacilli, Mycobacterium tuberculosis and is characterized by asymptomatic, non-culturability and antibiotic resistant state of disease. Conventional antibiotic therapy is only applicable to the active form of the disease. These non-replicating cells can resume the growth in immunosuppression state and cause the symptomatic disease....
Open Access DOI:10.23937/2378-3516/1410024
Shorofsky M, Lebel M, Sedeno M, Zhi Li P and Bourbeau J
Article Type: Original Article | First Published: August 03, 2015
Background: COPD is associated with significant morbidity, mortality, and hospital costs. The implementation of COPD 'discharge care bundles' has been proposed as having an impact on readmissions. We developed and implemented a discharge care bundle and the aim of this study was to evaluate its effects on utilization of hospital services in a real life setting. Methods: We conducted a retrospective chart review study from 2007-2013 to evaluate ut...
Open Access DOI:10.23937/2378-3516/1410023
Keita Matsumoto, Tomotaka Kawayama, Takashi Kinoshita, Shuwa Minami, Kazuko Matsunaga, Masako Nagafuchi, Tomoaki Hoshino and Toru Rikimaru
Article Type: Original Article | First Published: July 22, 2015
Background: The relationship between chronic rhinosinusitis (CRS) and airflow obstruction is still unclear. This cross-sectional study was conducted to investigate whether CRS is an independent risk factor for airflow obstruction in never-smokers without asthma. Methods: One hundred fifty-eight subjects aged ≥ 40 yr without asthma were divided into 4 groups: 22 never-smokers with CRS, 27 smokers with CRS, 69 never-smokers without CRS, and 4...
Open Access DOI:10.23937/2378-3516/1410022
Maria M Wilczynska and Helen E Davies
Article Type: Case Report | First Published: July 20, 2015
Malignant pleural effusion (MPE) is a common presenting feature of underlying malignancy and frequently results in debilitating symptoms. In chemosensitive malignancies, such as lymphoma, small cell lung or ovarian cancers, chemotherapy is often considered the fist line treatment, however if unsuccessful, pleural intervention to achieve fluid control is required. This may include therapeutic thoracentesis, chest drain insertion, thoracoscopy, che...
Open Access DOI:10.23937/2378-3516/1410021
Chandima P Karunanayake, James A Dosman, Louise Hagel, Donna C Rennie, Joshua A Lawson, Punam Pahwa and Saskatchewan Rural Health Study Group
Article Type: Original Research Article | First Published: June 22, 2015
Background: Pulmonary function tests are used routinely to evaluate patients with respiratory diseases and those who are at risk of developing respiratory diseases. Lung function prediction equations are generally developed for urban populations and whether these differ on rural population is not well studied. There is limited information on prediction equations for rural populations. Objective: The purpose of the present study was to derive pred...
Open Access DOI:10.23937/2378-3516/1410020
Alberto Garcia-Zamalloa, Mar Zabalo, Milagros Berruete and Elena Telleria
Article Type: Case Report | First Published: April 08, 2015
An obese 85 year-old woman was admitted to the hospital because of extreme dyspnoea after one week with fever and cough. She had been previously diagnosed with myelodysplastic syndrome, chronic renal failure with creatinine 2 mg/dl, glomerular fitrate 25 ml/min; and cirrhosis with moderate persistent ascites despite diuretic treatment and mild pleural effusion reaching a fit of the right hemithorax....
Open Access DOI:10.23937/2378-3516/1410019
Rajapriya Manickam, Kabir Oladipo Olaniran and Raghu Loganathan
Article Type: Case Report | First Published: April 06, 2015
Coccidioidomycosis is caused by inhalation of Coccidoides spores which is endemic in south western parts of USA and an uncommon cause of pneumonia in non-endemic areas. We report a young Hispanic man who lives in New York presenting with diabetic ketoacidosis and severe pulmonary Coccidioidomycosis....
Open Access DOI:10.23937/2378-3516/1410018
Jinxin Cao, Jinbai Miao and Hui Li
Article Type: Research Article | First Published: April 03, 2015
Pathogenesis of primary spontaneous pneumothorax (PSP) is unclear and has been rarely reported in the literature. Thus, we measured expression of Krebs Vonden Lungen-6 (KL-6), firoblast growth factor-10 (FGF-10), and matrix metalloproteinase-9 (MMP-9) in PSP samples and evaluated their significance on the development and progress of the disease....
Open Access DOI:10.23937/2378-3516/1410017
Article Type: Editorial | First Published: April 02, 2015
It is true that pulmonary medicine is already well served by several specialist journals, but it is also true that it remains difficult to publish the overwhelming amount of research articles in this rapidly growing field. This is particularly the case for the researchers from the developing countries, who contribute only a limited proportion to the total research output published in leading medical journals....
Open Access DOI:10.23937/2378-3516/1410016
Article Type: Review Article | First Published: March 21, 2015
Community-acquired pneumonia is defined as an acute infection of the pulmonary parenchyma in a patient who has acquired the infection in the community. CAP remains a common and potentially serious illness. It is associated with considerable morbidity, mortality and treatment cost, particularly in elderly patients. CAP causes problems like difficulty in breathing, fever, chest pains, and cough....
Open Access DOI:10.23937/2378-3516/1410015
Benito Vargas-Abrego, Pablo Alvarez-Maldonado, Rosa M Alcazar-Lopez, Francisco C Lorente-Ludlow and Carlos Nunez-Perez Redondo
Article Type: Case Report | First Published: February 24, 2015
Primary mediastinal goiter is a rare entity. In most cases their finding is incidental. Excision is mandatory because of the risk of compression of vital structures within the chest. We report the case of a primary posterior mediastinal goiter that was resected through a cervical approach....
Open Access DOI:10.23937/2378-3516/1410014
Esmehan Akpinar, Serdar Akpinar and Nazire Ucar
Article Type: Research Article | First Published: February 15, 2015
Objective: Obesity has many negative effects on lung functions. It is not yet clear whether body mass index (BMI) affects the success of noninvasive mechanical ventilation (NIMV). The aim of this study was to investigate the differences in NIMV strategies, on the basis of BMI, in patients with acute hypercapnic respiratory failure and the effect of BMI on the success of NIMV. Methods: A total of 86 patients who had acute hypercapnic respiratory f...
Open Access DOI:10.23937/2378-3516/1410013
Ajit A. Sarnaik
Article Type: Case Report | First Published: February 08, 2015
Independent Lung Ventilation (ILV) has been used in the critical care setting as a rescue therapy for differential lung disease. The purpose of anatomic separation of the lungs is to prevent blood, purulent secretions, or other debris from one lung from contaminating the other lung. Physiologic separation of the lungs allows different ventilator strategies to be applied to each lung. We report the case of the successful use of ILV in a man with c...
Open Access DOI:10.23937/2378-3516/1410012
Luis del Carpio-Orantes
Article Type: Mini Review | First Published: January 28, 2015
After the pandemic influenza H1N1 2009, there are many lessons learned regarding the diagnosis and treatment of patients affected by this virus. However, there have also been a number of contingencies that have greater concern to the world population, mainly by new types as infectious outbreaks, as well as the report of virus mutations that confer resistance to common treatment widely used. For new outbreaks have resulted in a new calamity, after...
Open Access DOI:10.23937/2378-3516/1410011
Vijay Hadda, Kavitha Venkatnarayan, Karan Madan, Anant Mohan and GC Khilnani
Article Type: Case Report | First Published: January 26, 2015
A 25-year-old female patient presented with dry coughs of 20 days duration and fever for four days. Examination of respiratory system revealed no significant abnormality. Chest radiograph was normal. CT scan of the thorax revealed endobronchial opacity in the right main bronchus suggestive of a foreign body. Patient retrospectively recollected history of betel nut aspiration just prior to onset of symptoms. Flexible bronchoscopy revealed a large ...
Open Access DOI:10.23937/2378-3516/1410010
F. Zoreka, H. Bouvaist, E. Vautrin, S. Marliere, R. Guerbaai, J. Labarere, G. Vanzetto and C. Pison
Article Type: Research Article | First Published: January 11, 2015
Background: International registries report an aging population suffering from PAH (Pulmonary Artery Hypertension) engendering diagnosis difficulties linked with growing cases of group 2 related to left heart failure with preserved Ejection Fraction (PH-HFpE). Pulmonary Capillary Wedge Pressure (PCWP) measurement by right heart catheterization remains a technical challenge for patient classification; many centers still use digital PCWP given by c...
Open Access DOI:10.23937/2378-3516/1410009
Morhaf AlAchkar, David E. Geller, Amanshe Perera Slaney and Daniel T Layish
Article Type: Research Article | First Published: January 04, 2015
Objectives: Cystic fibrosis (CF) is a complex genetic disorder of the lower and upper respiratory tract. The purpose of this study is to evaluate the effect of Halotherapy on sinusitis symptoms, dyspnea, pulmonary function tests, and quality of life in CF patients. Study design: This was a pilot open-label before-and-after-study. Settings: The study was performed at the Orlando Salt Room. Participants were from a single CF care center, and were e...
Open Access DOI:10.23937/2378-3516/1410008
Callejas Gonzalez FJ, Genoves Crespo M, Cruz Ruiz J, Tornero Molina AI, Esquinas Lopez C, Bermejo Lopez P, Garcia Castillo S, Martinez Garcia AJ, Rodriguez Montes JA5 and Tarraga Lopez PJ
Article Type: Research Article | First Published: January 04, 2015
838 patients referred 559 attended to and only 278 treated (33%); 55.4% males and 44.6% females; mean age of 46.4 years. The most important comorbidities were psychiatric (36.3%), cardiovascular (dyslipidemia 30.2%, hypertension 19.1%, diabetes 9.4%) and respiratory (chronic obstructive pulmonary disease (COPD), 15.1%; Obstructive Sleep Apnea Syndrome (OSAS), 11.9%; asthma, 7.6%). Treatments included varenicline (VRN), 36.7%, nicotine replacement...
Open Access DOI:10.23937/2378-3516/1410007
Takaaki Osako, Michiko Aoyama-Ishikawa, Hayato Yamashita, Makoto Usami, Atsunori Nakao and Joji Kotani
Article Type: Original Article | First Published: December 26, 2014
Introduction: During acute lung inflammation, the lung microvasculature becomes hyperpermeable, resulting in immune cell infiltration and tissue edema. N-3 polyunsaturated fatty acids (PUFAs), when used as a supplement in parenteral nutrition, can attenuate Lipopolysaccharide (LPS)-induced lung injury. In this study, we examined the effects n-3 PUFAs on lung microvascular cell permeability. Material and methods: Human lung microvascular endotheli...
Open Access DOI:10.23937/2378-3516/1410006
John Fani Srour
Article Type: Case Report | First Published: December 15, 2014
The ductus arteriosus, an essential fetal structure, normally closes spontaneously soon after birth. It's persistence into late adulthood is considered rare; infective endarteritis complicating a patent ductus arteriosus (PDA) is an even rarer event. The clinical picture of an infected PDA could be subtle, and the diagnosis is frequently delayed. Symptoms may well be attributed to community acquired pneumonia, pleurisy, or pulmonary infarction fr...
Open Access DOI:10.23937/2378-3516/1410005
Mehmet Unlu, Pinar Cimen, Nuran Katgi and Salih Zeki Guclu
Article Type: Case Report | First Published: December 06, 2014
A variety of airway tumours are reported to manifest with symptoms similar to those of asthma and may cause delays in exact diagnosis because of the increase in size at a slow rate. Pulmonary endobronchial mesenchymoma is one of the slow growing tumours which is associated with symptoms or signs of airway obstruction mimicking asthma. So, patients with chronic symptoms suggestive of asthma, poor response to asthma medications, and frequent exacer...
Open Access DOI:10.23937/2378-3516/1410004
Neal M Patel, Vichaya Arunthari, Michael Heckman and Charles D Burger
Article Type: Original Retrospective Study | First Published: October 10, 2014
Background: In patients with Pulmonary Hypertension (PH), the role of overnight oximetry as means to screen for Sleep Disordered Breathing (SDB) has not been well established. The aim of this study was to assess whether overnight oximetry was additive to a standard sleep questionnaire in the diagnosis of SDB. Methods: This retrospective study included 94 PH patients seen at Mayo Clinic Florida PH Center from 1992 to 2006. Analysis was performed o...
Open Access DOI:10.23937/2378-3516/1410003
Rodriguez DA, Orozco-Levi M, Miranda F, Mayoral A, Clements JA, Martinez-Llorens J, Ventin C, Bruguera J, Gea J and Molina LL
Article Type: Research Article | First Published: September 10, 2014
Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a known risk factor for pulmonary embolism (PE); however, neither the clinical nor the pulmonary function characteristics are well described in COPD patients admitted for PE. Methods: We conducted a retrospective cohort study of 395 patients admitted for acute PE in a tertiary hospital setting. In COPD patients, clinical characteristics and pulmonary function were compared between the ...
Open Access DOI:10.23937/2378-3516/1410002
Tong Zhou and Ting Wang
Article Type: Editorial | First Published: August 18, 2014
Genome wide association studies (GWAS) have resulted in the identification of novel genetic loci associated with a variety of diseases and clinical phenotypes, including complex lung disease such as asthma and COPD. However, the translational utilization of these expensive datasets has been restricted by multiple reasons including limited methodology to understand the exact molecular function of these single nucleotide polymorphisms (SNPs)....
Open Access DOI:10.23937/2378-3516/1410001
Omar Assasa, Mohamed Omballi and Fayez Kheir
Article Type: Editorial | First Published: August 06, 2014
Sarcoidosis is a multisystem inflammatory disease of unknown etiology that is characterized by noncaseating granuloma. Its incidence is 11 cases per 100,000 population in whites and 34 cases per 100,000 population in African Americans. Sarcoidosis most often involves the lung and intrathoracic lymph nodes but can occur in any other organ system. The most common respiratory complaints are dyspnea, shortness of breath and wheezing. However, many pa...
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