Aghabiklooei A, Mehrpour O, Hassanian-Moghaddam H, Shadnia S, Zamani N (2018) Outcome of Self- and Planned Extubation in Organophosphate-Poisoned Patients. Int J Anesthetic Anesthesiol 5:075.


© 2018 Aghabiklooei A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

ORIGINAL ARTICLE | OPEN ACCESS DOI: 10.23937/2377-4630/1410075

Outcome of Self- and Planned Extubation in Organophosphate-Poisoned Patients

Abbas Aghabiklooei1, Omid Mehrpour2, Hossein Hassanian-Moghaddam3,4, Shahin Shadnia3,4 and Nasim Zamani3,4*

1Department of Legal Medicine and Toxicology, Firoozgar Hospital, Iran University of Medical Sciences, Iran

2Faculty of Medicine, Birjand University of Medical Sciences, Iran

3Department of Clinical Toxicology, Loghman-Hakim Hospital, Iran

4Excellence Center of Clinical Toxicology, Iranian Ministry of Health, Iran



Respiratory failure is the most common cause of morbidity and mortality in organophosphate (OP)-intoxicated patients. We aimed to assess and compare the need for re-intubation and outcome between patients with self-extubation (SE) and planned extubation (PE).


All OP-poisoned endotracheally intubated patients admitted to poisoning ICU were included. The frequency and time of SE, need for re-intubation, and its impact on hospital stay and outcome were assessed.


In fifteen patients (48.4%) SE was reported. Need for re-intubation in these patients was more than those who underwent PE (60.0% vs. 37.5%; P = 0.2). Early unplanned SE significantly correlated with occurrence of pulmonary complications (P = 0.04). The rate of aspiration pneumonia was high (80%) in SE cases. Hospital stay was also significantly prolonged in these patients (14.6 vs. 5.4 days, P = 0.04).


Planning for on-time weaning/extubation in OP-poisoned patients can prevent unplanned SE and decrease the occurrence of lung complications.