Chong D, Ge G, Li D, Yang Y, Wang R, et al. (2019) Remission of Psoriasis during Treatment with Apatinib in a Patient with Rectal Cancer. J Dermatol Res Ther 5:068.


© 2019 Chong D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

CASE REPORT | OPEN ACCESS DOI: 10.23937/2469-5750/1510068

Remission of Psoriasis during Treatment with Apatinib in a Patient with Rectal Cancer

Daoqun Chong1, Gai Ge2, Dongmei Li3, Yang Yang1, Rong Wang1, and Dongmei Shi, MD, PhD1*

1Department of Dermatology, Jining No 1 People's Hospital, Jining, Shandong, China

2Jining Medical University, Jining, Shandong, China

3Georgetown University Medical Center, Washington DC, USA


Psoriasis is a chronic, recurrent inflammatory skin disease characterized by abnormal keratinocyte proliferation and vascular hyperplasia. Apatinib is a tyrosine kinase inhibitor which has been reported to be effective in some tumors thought to be associated with inhibition of the proliferation of endothelial cells by selectively inhibiting vascular endothelial growth factor receptor-2 (VEGFR-2). We present a 54-year-old patient with a 30-year history of psoriasis, who did not respond well to oral treatment with acitretin in combination with topical corticosteroids. The patient was diagnosed with rectal cancer and was treated with oral apatinib 250 mg once daily. To our surprise, all the psoriasis lesions were completely resolved after a 53-days course of treatment. Although apatinib and its variants have been extensively used as an anticancer drug, there is no report of their use in psoriasis. As with other antitumor treatments, we speculate that apatinib is effective for psoriasis owing to an inhibition of endothelial cell growth in psoriasis lesions. This observation suggests that apatinib may be a useful drug to treat psoriasis in the future and deserves further investigation in its own right.