Remission of Psoriasis during Treatment with Apatinib in a Patient with Rectal Cancer
Daoqun Chong, Gai Ge, Dongmei Li, Yang Yang, Rong Wang, and Dongmei Shi, MD, PhD
Article Type: CASE REPORT | First Published: March 14, 2019
Psoriasis is a chronic, recurrent inflammatory skin disease characterized by abnormal keratinocyte proliferation and vascular hyperplasia. Apatinib is a tyrosine kinase inhibitor which has been reported to be effective in some tumors thought to be associated with inhibition of the proliferation of endothelial cells by selectively inhibiting vascular endothelial growth factor receptor-2 (VEGFR-2). We present a 54-year-old patient with a 30-year history of psoriasis, who did not respond well to or...
Use of Vibrational Optical Coherence Tomography to Image and Characterize a Squamous Cell Carcinoma
Frederick H Silver, Ruchit G Shah, Michael Richard and Dominick Benedetto
Article Type: ORIGINAL ARTICLE | First Published: March 08, 2019
Previous literature reports suggest that tissue stiffness is a predictor of cancer and metastatic behavior. We have used optical coherence tomography and vibrational analysis (VOCT) to characterize normal skin, scar and a verrucous carcinoma, a squamous cell carcinoma subtype, non-invasively and non-destructively. The results suggest that epidermal thickening and increased keratin production occur in verrucous carcinoma and lead to increases in surface hills and valleys as well as subsequent inc...
Management of Cutaneous Toxicity Secondary to Targeted Agents in Melanoma
Maria del Carmen Pantin Gonzalez, Diego Malon Gimenez, Beatriz Losada Vila, Beatriz Anton Pascual, David Gutierrez Abad, Nadia Sanchez Banos and Cristina Sanchez Cendra
Article Type: CASE REPORT | First Published: February 28, 2019
Melanoma is the most aggressive skin cancer and its incidence continues to increase worldwide. Molecular targeted kinase inhibitors have improved survival and tumor response for those patients with BRAF mutant disease. We describe the case of a patient under treatment with BRAF and MEK inhibitors (BRAFi and MEKi) who presents cutaneous toxicity grade 3, as an adverse effect due to treatment....
Nail Disorders in Patients with Chronic Renal Failure
Niema Aqil, Aicha Nassiri, Salim Gallouj and Fatima Zahra Mernissi
Article Type: Original Article | First Published: January 28, 2019
Ungual manifestations occurring in patients with end stage renal failure are polymorphic and diverse. The aim of our study was to assess the prevalence and characteristics of different ungual manifestations in patients end stage renal failure. We led a transverse investigation of all patients with end stage renal failure followed in the department of nephrology of University Hospital Hassan II, during a period of three months from 01 August 2016 to 01 November 2016....
Case of Th2 Cytokines in a Japanese Girl Who Acquired Hookworm-Related Cutaneous Larva
Makoto Kondo and Keiichi Yamanaka
Article Type: Case Report | First Published: January 11, 2019
One of the symptoms of creeping disease in humans is the accidental occurrence of hookworm-related cutaneous larva migrans (HrCLM). It usually occurs following contact with soil, sand, and mud found on beaches in tropical countries. Skin eruptions, such as linear nodules, appear on the foot and lower extremities. Misdiagnosis and inefficient treatment for travelers have often been reported. Although the parasite species remained unidentified in our case, the characteristic skin eruption in combi...
Dermoscopic Features of Linear Porokeratosis: Different Aspects in its Development
Meltem Turkmen, Bengu Gerceker Turk, Isıl Kilinc Karaarslan, Gulsen Kandiloglu and Fezal Ozdemir
Article Type: Original Article | First Published: January 10, 2019
A 22-year-old-woman admitted with linear brownish papules and plaques on the right side of the trunk. The lesions initially had appeared on the right mammary at the age of 2-months and disseminated regionally throughout the axilla. The patient was previously followed with the diagnosis of epidermal nevus by some other physicians. On dermatologic examination, red-brown hyperkeratotic linear and annular plaques with elevated borders extending from the right mammary to the right axilla along the Bl...