Bocalon IL, Marques MHV, Filho IJZ (2019) Approaches to the Potential Use of Stromal Vascular Fraction and Coenzyme Q10 in Dermatological Aesthetics: A Systematic Review. J Dermatol Res Ther 5:070.


© 2019 Bocalon IL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

RESEARCH ARTICLE | OPEN ACCESS DOI: 10.23937/2469-5750/1510070

Approaches to the Potential Use of Stromal Vascular Fraction and Coenzyme Q10 in Dermatological Aesthetics: A Systematic Review

Isabela de Lima Bocalon1, Mayara Fernandes Veri Marques1 and Idiberto José Zotarelli Filho2*

1Medical School, União Das Faculdades Dos Grandes Lagos (Unilago), São José do Rio Preto/SP, Brazil

2Department of Scientific Production, Post Graduate and Continuing Education (Unipos), São José do Rio Preto SP, Brazil



With aging, occurs a decrease in the number of melanocytes active enzymatically around 12.0% to 24.0% every ten years. As a treatment, stem cell therapy with adult stem cells has been the focus of many studies. Among adult stem cells, adipose-derived stem cells (ADSC) ubiquinone, known as coenzyme Q10 (CoQ10), is a lipid-soluble antioxidant. It is shown to reduce lipid peroxidation of low-density lipoprotein regenerates endogenous vitamin E and protects cells against oxidative stress induced by UV radiation.


To explore through the literature review the use of cellular therapy with stromal vascular fraction and coenzyme Q10 to meet the dermatological aesthetics.


Use of Mesh terms: Adipose-derived stem cell. Estromal Vascular Fraction. Aesthetics. Dermatology. In the main databases such as Pubmed, Medline, Bireme, EBSCO, Scielo, etc. The total of 63 papers that were submitted to the eligibility analysis was cross-checked and after that 23 studies were selected, following the rules of systematic review-PRISMA.


The production and secretion of growth factors have been identified as an essential function of ADSC, and many skin rejuvenation effects have been demonstrated [1,2]. Thus, ADSC has been shown to stimulate collagen synthesis and dermal migration of fibroblasts during the wound healing process. In addition, the secreted factors of the ADSC protect the dermal fibroblasts against oxidative stress. CoQ10 is also known as ubidecarenone or ubiquinone. This liposome penetrates deep into the epidermis and releases noble actives directly into the sites of action. Powerful antioxidant reduces the organic aging process.


The use of stromal vascular fraction is an important option for dermatological aesthetics, according to the observation of the results obtained in this study. This procedure should be improved and has been widely discussed, mainly because it can be performed as an autologous material and associated with the use of coenzyme Q10.