Lupus miliaris disseminatus faciei (LMDF) is a rare benign dermatosis, of unknown etiology and treatment often disappointing.

An 18-year-old patient presented with lupoid papulonodular lesions in the face. The diagnosis of disseminated lupus of the face was retained after eliminating other diagnoses including sarcoidosis, syphilis and leprosy. An antibacillary treatment was started without improvement for 3 months with onset of lesions. A 0.5 mg/kg/day isotretinoin treatment was started with improvement of the lesions. Thereafter, the patient benefited from 6 sessions of injection of platelet-rich plasma (PRP) with sagging scars.

LMDF is an enigmatic entity, still controversial even though it is widely recognized. Some consider it an entity in its own right whose etiopathogenesis remains to be elucidated.