Open Access DOI:10.23937/2474-3658/1510299
Current Strategies to Improve Efficiency of Recombinant Subunit Vaccines
Bahar ASLANBAY GULER and Esra IMAMOGLU
Article Type: Original Review | First Published: 2023/04/17
Global population growth and rising health concerns have highlighted the importance of developing effective vaccination strategies, and subunit vaccines hold great promise for meeting market demand. Compared to traditional whole-cell vaccines, subunit vaccines contain only a part of the infectious microorganism to induce an immune response against the main pathogen. ...
Open Access DOI:10.23937/2474-3658/1510297
Acute Thyroiditis Complicating a Systemic Parvovirus B-19 Infection: A Unique Adult Case Report in Italy and Literature Review
Antonio Mastroianni, MD, Sonia Greco, MD, Valeria Vangeli, MD, Maria Vittoria Mauro, MD and Roberto Manfredi, MD
Article Type: Letter to the Editor | First Published: March 29, 2023
A very rare case of acute Graves-Basedow adult disease prompted by a systemic Parvovirus B-19 infection is presented and discussed, on the basis of the most recent literature evidences in this field. Parvovirus B19 is a small virus parasiting erythrocytes frequently underestimated in clinical practice, when excluding patients with severe hematological diseases....
Open Access DOI:10.23937/2474-3658/1510296
Maternal Death Due to Late COVID-19 Diagnosis in Moyamba District Sierra Leone, 2021, Case Report
Brima Akwame Gamanga, Adel Hussein Elduma, Gbessay Saffa, Jean Leonard Hakizimana, Kassim Kamara, Amara Alhaji Sheriff and Gebrekrstos Negash Gebru
Article Type: Case Report | First Published: March 26, 2023
Little information exists on maternal deaths related to COVID-19 disease. We investigated maternal death due to COVID-19 infection and identify risk factors in Sierra Leone, 2021. We collected demographic and clinical data, reviewed medical records, and COVID-19 vaccination status. The decedent was nurse, 34-years-old, pregnant, 20 weeks gestation, and working at the district hospital. The pregnant woman died on June 26, 2021 with positive COVID-19 result....
Open Access DOI:10.23937/2474-3658/1510260
An Accuracy-Based Approach to the Microbiologic Diagnosis of Pulmonary Infection: Part III
John Ferguson, MD, MPH, Cyprien Jungels, DO and Michael Gailey, DO
Article Type: Original Research | First Published: May 12, 2022
Similar to that of bacterial infection as described in Part 1 and fungal infection described in Part 2, the performance of diagnostic tests for viral pneumonia and parasitic pneumonia are not well described. We undertook a literature search to assess the accuracy of diagnostic tests for pneumonia, identified through a search of MEDLINE-indexed journals. Sensitivity and specificity of diagnostic tests for pneumonia were calculated with respect to various reference standards. A battery of diagnost...
Open Access DOI:10.23937/2474-3658/1510259
Emergence of Marburg Virus Disease in West Africa amid COVID-19 and Ebola: Efforts, Challenges, and Recommendations to Prevent the Next Public Health Crisis
Jannel A Lawrence, BSc, Muhammad Haseeb Ul Rasool, MBBS, Charmy Parikh, MBBS, Selia Chowdhury, MBBS, Alexandra Sueldo, BSc, Sarosh Sarwar, MBBS, Arpit Mago, Pawan Kumar Thada, MBBS and Mona Skeikh, MD
Article Type: Review Article | First Published: April 30, 2022
Marburg virus disease (MVD) is a type of hemorrhagic fever caused by a genetically unique animal-borne RNA virus of the filovirus family-like Ebola virus. The African fruit bat is the known reservoir of this virus, and due to its animal-to-animal, animal-to-human, and human-to-human transmission patterns, it is capable of rapid spread. The history of previous MVD outbreaks shows that this can be highly fatal, and the fatality rate can reach up to 90%. Most MVD outbreaks have been in Africa and c...
Open Access DOI:10.23937/2474-3658/1510258
Acute Bell’s Palsy: A Neurological Manifestation of the Severe Acute Respiratory Syndrome (SARS-CoV-2)
Cameron YS Lee, DMD, MD, PHD, MPH, MSEd
Article Type: Case Report | First Published: April 30, 2022
The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection affects multiple organ systems with varied clinical presentation. The most frequently reported signs and symptoms associated with COVID-19 infection involve the cardiovascular and respiratory systems and include fever, cough, and shortness of breath. However, clinicians should be aware that neurological manifestations could be the only clinical sign and symptom reported by patients infected...
Open Access DOI:10.23937/2474-3658/1510257
Role of Clinical, Laboratory, and Radiological Manifestations in Prognostication of COVID-19 in 804 Patients Admitted to Three Tertiary Care Centers in Dubai, United Arab Emirates
Rommana Mehdi, Arshee Khan, Priyank Gupta, Aisha Siddiqui, Anam Ahsan, Mona Hosseini, Farah Ghayoor, Jawahir Tahir, Samya Javed, Saubia Fathima, Zufana Nasir, Hana Mohd Sughaiyer, Erum Rehman, Nimmi Moni, Salama Buqaish, Eman Abdelwahed, Deema Harb, Beyla Zuberi and Laila AlDabal
Article Type: Original Research | First Published: April 20, 2022
December 2019 heralded the onset of the 2019 novel coronavirus (SARS-CoV-2) outbreak in the Hubei province in China. Ever since the disease has spread across continents resulting in rising magnitudes of cases and fatalities. SARS-CoV-2 is a beta coronavirus that belongs to the family Coronaviridae and order Nidovirales. Six coronavirus species have been identified to infect humans and cause mild disease so far; SARS-CoV-2 is the seventh member of the coronaviruses that infect humans. Fatal illne...
