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International Journal of

Blood Research and DisordersISSN: 2469-5696

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 Open Access DOI:10.23937/2469-5696/1410060

System Biology: An Emerging Toolkit for Improved Tyrosine Kinase Inhibition Therapy for Myeloproliferative Neoplasms

Alphonsus Ogbonna Ogbuabor, PhD, Peter Uwadiegwu Achukwu, PhD, Silas Anayo Ufelle, PhD and Daniel Chukwuemeka Ogbuabor, PhD

Article Type: Review Article | Indexed Archive: Volume 7

Concerted efforts have been made by scientists over the last decades in elucidating the molecular mechanisms leading to myeloproliferative neoplasms. The identification of oncogenic mutations in signal transduction pathways revealed the role of specific pathways in inducing excessive proliferation of myeloid lineages. The subsequent development of mouse models carrying mutations found in patients proved that the aberrant activation of these specific pathways plays a crucial role in the pathology...

 Open Access DOI:10.23937/2469-5696/1410059

Erythrocyte Alloimmunization in Children with Sickle Cell Disease

Daniela de Oliveira Werneck Rodrigues, Lysla Cardoso Sudário, Olivia Franco dos Santos, Leonardo de Angelli Benedito Cardoso and Luiz Claudio Ribeiro

Article Type: Original Article | Indexed Archive: Volume 7

Alloimmunization is an immune response against red blood cell (RBC) antigens due to sensitization during RBC transfusion. RBC alloimmunization is more common in sickle cell disease (SCD) with prevalence between 18 and 47%. Retrospective chart review of a cohort of 120 children treated at Fundação Hemominas born between 1998 and 2007 and diagnosed with SCD through neonatal screening. The statistical analysis was made with the usage of Mann-Whitney’s U test, Student’s T-test and Chi-Square t...

 Open Access DOI:10.23937/2469-5696/1410058

Coping with Bleeding Disorders

Tony Brown

Article Type: Case Report | Indexed Archive: Volume 6

Living with a bleeding disorder is something that very few live within the United States. In fact, hemophilia occurs in only approximately 1 in 5,000 live births. There are about 20,000 people with hemophilia A in the US. Hemophilia B is four times less common than hemophilia A. von Willebrand Disease is much more common than both hemophilia A & B which is believed to effect 1% of the population. Von Willebrand disease is estimated to affect 1 in 100 to 10,000 individuals. The 3 common bleeding ...

 Open Access DOI:10.23937/2469-5696/1410057

Enzyme Activities of Liver Function (Biomarkers) in Sickle Cell Anaemic Patients Attending Sickle Cell Anaemic Centre, Benin City, Edo State, Nigeria

Collins Uchechukwu Obi, Okikioluwa Stephen Aladeyelu, Ijeoma Nnenna Agbiogwu, Nneka Chidimma Agu, Joseph Akinwale Arusiwon and Mercy Oluchukwu Udeh

Article Type: Survey Article | Indexed Archive: Volume 7

Hundred subjects were involved for this study. The subjects were divided into 2 groups: 50 sickle cell anaemic subjects (20 males and 30 females) and 50 non-sickle cell subjects or control (23 males and 27 females). Sickle cell anaemic subjects were between the age ranges of 15-41 years while control subjects were between 17-31 years. Subjects were both Sickle Cell Anaemic Centre, Benin City, Edo State, Nigeria and volunteer students at the Department Medical Laboratory Science, Ambrose Ali Univ...

 Open Access DOI:10.23937/2469-5696/1410056

Laboratory Blood Coagulation in Sudanese with Falciparum Malaria: A Glance of Change Outcomes

Bashir Abdrhman Bashir and Mohamed Seed Ahmed

Article Type: Original Research | Indexed Archive: Volume 7

Malaria is a potentially life-threatening disease caused by infection of erythrocytes with one of five different types of protozoan parasites of genus plasmodia. Falciparum species is an aggressive type associated with multiple alterations in hemostasis. A cross-sectional descriptive study was undertaken to screen the effect of malaria infection on coagulation test results in adults with the falciparum malaria parasite. Forty- eight consecutive adults with falciparum malaria were studied along w...

 Open Access DOI:10.23937/2469-5696/1410055

The Effects of Assymptomatic Malaria on Some Haematological Parameters among the Elderly in a Sub-Urban Community in Southern Nigeria

Eledo BO, Tommy EO, Onuoha EC, Dunga KE and Okamgba OC

Article Type: Review Article | Indexed Archive: Volume 7

Malaria remains a major public health problem in endemic areas and due to neglect, the elderly ones are even more exposed now. The objective was to determine the effects (if any) of asymptomatic malaria on some hematological parameters on infected elderly subjects, identify subjects at risk of severe hematological derangement and render advice appropriately. One hundred healthy subjects (45 males and 55 females) having ≥ 60-years-old and without clinical symptoms, were screened for malaria par...

 Open Access DOI:10.23937/2469-5696/1410054

Influence of ABO Blood Group on Fibrinogen Levels and Platelet Count in Apparently Healthy Nigerian Subjects

Okeke CO and Iloka VC

Article Type: Original Article | Indexed Archive: Volume 7

A close association has been shown to exist between ABO blood type and the risk of some diseases with non-O (A, B, or AB) individuals having an increased differential disposition to thrombotic disorders. The present study evaluated the fibrinogen levels and platelet count in subjects of different ABO blood groups with the view of ascertaining if disparity exists in the levels of fibrinogen and platelet count amongst the different ABO blood groups....

 Open Access DOI:10.23937/2469-5696/1410053

First Report of Hemoglobin Le Lamentin [Alpha 20 (B1) His -> Gln] in the Alpha1 Globin Gene in an Indian Patient and a Brief Update

Sona B Nair, Arundhati S Athalye, Prochi F Madon and Firuza R Parikh

Article Type: Case Report | Indexed Archive: Volume 7

Alpha globin gene structural variants are caused mainly due to point mutations in the alpha globin gene. They are generally asymptomatic but in rare cases cause problems in association with other structural variants of thalassemia. We report here for the first time in Indian population a rare alpha globin gene structural variant named Hb Le Lamentin. Our main aim of presenting this case is to create awareness that this variant may be commonly present in the Indian population also though the prev...

 Open Access DOI:10.23937/2469-5696/1410052

Hemopure, HBOC-201, for Life Threatening Anemia in a Jehovah’s Witness

Joseph R Nellis, MD, MBA, Michael J Devinney, MD, PhD, Christopher C Young, MD

Article Type: Case Report | Indexed Archive: Volume 7

There are over 1 million Jehovah’s Witnesses in the United States and nearly 8.5 million worldwide. Within the medical community, they are most notably known for their refusal of blood transfusions. Prior studies have shown that healthy euvolemic volunteers tolerate hemoglobin of 5 g/dL, although when faced with the stress of surgery their operative mortalities are over 30%. Herein we explore the use of Hemopure, HBOC-201, an investigational blood substitute, for a frail 72-year-old female Jeh...

Volume 7
Issue 2