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International Journal of

Blood Research and DisordersISSN: 2469-5696

Early Online

 Open Access DOI:10.23937/2469-5696/1410095

Complications and Response to Treatment Regimens among Multiple Myeloma Patients Attended at Muhimbili National Hospital

Dorothy P Kasubi, Clara C Chamba, Neema Budodi and Samira Mahfudh

Article Type: Original Article | First Published: 2024/02/16

Multiple myeloma is a potentially fatal hematological malignancy characterized by clonal growth of terminally differentiated B cells. The development of novel medicines (proteasome inhibitors, immunomodulatory medications, antibodies targeting cell surface molecules, and autologous stem cell transplantation) has improved patients' quality of life and overall survival rate with multiple myeloma. Despite the advancement of these new therapies that help resolve disease progression and hence provide...

 Open Access DOI:10.23937/2469-5696/1410094

C-mip Involvement as a Thrombosis Risk Factor in Children with Idiopathic Nephrotic Syndrome in Abidjan, Côte D'Ivoire

N'Draman-Donou AE, Yapo AVDP, Koumi-Mélèdje MD, Adjambri AE, N'Guessan-Blao AR, Ehilé-Kacou AM, Bouah-Kamon E, Diarrassouba G, Adjé ML, Sangaré-Bamba M, Lasme-Guillao E and Sawadogo D

Article Type: Original Article | First Published: 2023/12/04

The risk of thrombosis due to idiopathic nephrotic syndrome (INS) appears to be proportional to massive protein leakage. This massive leak could be linked to the overexpression of the c-mip gene. The objective of the current study was to investigate the involvement of the c-mip gene in the risk of occurrence of thrombosis in children with INS in Abidjan....

 Open Access DOI:10.23937/2469-5696/1410093

Case Report and Literature Review on Patient with Sticky Platelet Syndrome and a Series of It's Complications

Lamadrid-Gámez Karina, Lopez-Zendejas Martin, Esesarte-Rodriguez Marisol, Herrera-Rojas Armando, Contreras-Cárdenas Javier, Meraz-Nieto Ivan Eduardo and Torres-García José Javier

Article Type: Case Report | First Published: 2023/11/11

We present the case of a half-blood Mexican male, 48-years-old, with a family and medical history of multiple thromboembolic events that are directly associated with the diagnosis of sticky platelet syndrome. This condition has presented diverse complications of procoagulant activity due to insufficient management therapy. Sticky platelet syndrome is an autosomal disorder that is associated with thromboembolisms....

 Open Access DOI:10.23937/2469-5696/1410092

Correlation of Manual Peripheral Blood Smear Examination with RBC Indices and Histograms Obtained from an Automated Hematological Analyzer in Anemic Patients at Jimma Medical Center, Southwest Ethiopia, 2022

Woyesa Beyene, Tilahun Yemane, Dereje Abebe, Mahder Girma, Fisum Abebe, Menberu Wubete and Edosa Tadasa

Article Type: Original Article | First Published: 2023/11/11

The manual peripheral blood smear examination is a comprehensive examination of the blood film to detect clinically significant abnormalities in leukocyte, erythrocyte, and platelet morphology. It is a time-consuming technique, but it is a more cost-effective and sensitive technique than an automated hematological analyzer. On the other hand, the automated hematology analyzer is faster, more objective, and reduces labor cost but cannot reveal the variety of abnormal cells. ...

 Open Access DOI:10.23937/2469-5696/1410090

Clinical Features and Induction Outcome of Adult Patients with Acute Lymphoblastic Leukemia: Findings from a Large Tertiary Care Referral Center in Palestine

Yara Ameerah, Raghad Daas, Reema Salah, Basel Musmar, Riad Amer and Johnny Amer

Article Type: Original Article | First Published: February 11, 2023

To describe the clinical characteristics and the induction outcome of patients with acute lymphoblastic leukemia (ALL) in adulthood in Palestine. A Retrospective single-center study was conducted at An-Najah National University Hospital (NNUH) between January 2014 and December 2018. The files and electronic records of ALL patients were reviewed. All patients at least 15 years or older who were confirmed to have ALL by flow cytometry and started induction chemotherapy at NNUH were included. Descr...

 Open Access DOI:10.23937/2469-5696/1410089

The Relationship between Serum Ferritin and Platelet Count in Yemeni Blood Donors

Boshra Al-Absi and Mohammed Abdul Wahid Almorish

Article Type: Original Article | First Published: January 26, 2023

Regular blood donation often cause iron deficiency. Changes of platelet count have been associated with iron deficiency anemia. We aimed to study the correlation between serum ferritin and platelet count in blood donors. Full blood count was measured by Sysmex- KX- 21N Haematology Analyser. Serum ferritin was examined using electrochemiluminescence technology of Cobas e 411 Analyzer....

 Open Access DOI:10.23937/2469-5696/1410088

Prevalence and Causes of Deferrals among Repeat Blood Donors in Dar es Salaam Tanzania

Irene A Mteta, Clara Chamba, Neema Budodi and Ahlam Nasser

Article Type: Research Article | First Published: January 25, 2023

A well-functioning blood transfusion service is essential for effective health-care delivery. Despite the fact that blood transfusions can save lives, the role of blood transfusion services is to assure the supply of safe blood from healthy donors. Although having a sufficient supply of blood is critical in blood transfusion, the caveat is that the collection and transfusion protocol must not put both the receiver and the donor in danger....

 Open Access DOI:10.23937/2469-5696/1410087

Geographical Variation of Acute Promyelocytic Leukemia: A Single Center Study from Saudi Arabia

Assem Elghazaly

Article Type: Brief Report | First Published: December 11, 2022

There is no obvious underlying cause for de novo acute promyelocytic leukemia (APL). Recently two case studies showed that the virus torque teno mini (TTMV) has a role in the pathogenesis of APL/APL-like disease. Few studies reported seasonal or geographical clustering of the disease. As no local published research addressed the effect of these two factors on the incidence of the disease, we aimed to study the relationship between geographical and seasonal factors and the incidence of APL in the...

 Open Access DOI:10.23937/2469-5696/1410086

A Prospective, Observational Study to Assess Effect of DTT Treatment on ABO Isoagglutinin Titers in O Blood Group Donors

Shweta Ranjan, MBBS, Prashant Pandey, MD, Divya Setya, DNB and Supriya Kumari, MBBS

Article Type: Original Article | First Published: December 08, 2022

To determine actual concentration of clinically significant IgG antibodies, there is need to inactivate IgM antibodies. Aim of this study was to study effect of dithiothreitol (DTT) on ABO isoagglutinin titers performed by column agglutination technology (CAT) and conventional tube technique (CTT) and to compare results obtained by DTT treatment. This was a prospective, observational study conducted from October 2018 to March 2020. All consecutive O group donors were included. All samples were c...

 Open Access DOI:10.23937/2469-5696/1410085

A Prospective Observational Study to Compare Heat Inactivated ABO Isoagglutinin Titres Performed by CTT and CAT with Solid Phase Red Cell Adhesion (SPRCA) in O Blood Group Individuals

Shweta Ranjan, MBBS, Prashant Pandey, MD, Divya Setya, DNB and Supriya Kumari, MBBS

Article Type: Original Article | First Published: December 02, 2022

Measurement of actual concentration of IgG requires methods like heat inactivation (HI) of plasma. This study was aimed at comparing of heat treated ABO titers performed by conventional test tube technique (CTT) and column agglutination technique (CAT) with HA/SPRCA. This was a prospective, observational study conducted from October 2018 to March 2020. All consecutive O group donors who gave consent for participation were included. All samples were tested by CTT and CAT before and after HI (pCTT...

 Open Access DOI:10.23937/2469-5696/1410084

Iliopsoas Hematoma as Unusually Early Onset of Hemophilia A in a Young Infant

Coppo D, Rossi L, Raffaldi I, Aguzzi S, Castagno E, Ricca I and Bondone C

Article Type: Case Report | First Published: November 14, 2022

A 2-month-old infant was admitted for irritability and hypomobility of the left lower limb. Ultrasound revealed a deep hematoma of the iliopsoas muscle and coagulation tests showed increased activated partial thromboplastin time (aPTT). The finding of marked reduction of blood coagulation factor VIII (FVIII) led to the diagnosis of severe Hemophilia A. The infants were promptly put on i.v. factor VIII concentrates, resulting in rapid clinical improvement....

 Open Access DOI:10.23937/2469-5696/1410083

Magnetic Therapy of Anemia Caused by Inflammations

Manfred Fähnle

Article Type: Original Article | First Published: October 13, 2022

In my paper I describe the magnetic therapy of anemia caused by inflammations, and I explain the physical processes underlying this therapy. Anemia occurs when there are not enough healthy red blood cells to carry oxygen to the organs of the body. The patients suffering from anemia feel cold, tired and weak. The most common type of anemia is the iron deficiency anemia. Iron produces a substance in the red blood cells then enables them to carry oxygen (hemoglobin)....

 Open Access DOI:10.23937/2469-5696/1410082

Evaluation of Changes in Haemostatic Parameters in Pregnancy and Puerperium in Women attending Antenatal Clinic at Rivers State University Teaching Hospital, Nigeria

Echonwere-Uwikor, B.E, Moore-Igwe, BW, Chukuigwe-Igbere, O.E and Chuku, P.H

Article Type: Original Article | First Published: September 15, 2022

This was a cross-sectional study carried out in Rivers State University Teaching Hospital, Port Harcourt with the aim of determining the Changes in Haemostatic Parameters in Pregnancy and puerperium. A total of 500 age-matched apparently healthy women of reproductive age, which consisted of 200 (40%) pregnant women, 200 (40%) puerperium mothers and 100 (20%) non-pregnant women who served as controls were studied. Their ages ranged from 16 to 41 years (mean 27.4 ± 4.3 years)....

 Open Access DOI:10.23937/2469-5696/1410081

Current Trends in Classic Hairy Cell Leukaemia: Aetiology, Diagnosis and Therapy

Udoka Ogobuchi-Odo, MSc, Silas Anayo Ufelle, PhD and Ifeoma Uzoma Agbo, MSc

Article Type: Review Article | First Published: August 29, 2022

Hairy cell leukaemia (HCL) is a rare B-cell neoplasm characterized by pancytopenia, splenomegaly and presence of hairy leukaemic B-cells in the bone marrow. Its aetiology is not clear but occupational and environmental factors are possible risk factors....

 Open Access DOI:10.23937/2469-5696/1410080

Under Reported Potentials of Low Foetal Haemoglobin Concentration in Sickle Cell Disease

Yusuf Ishaya Dogonzo, Obinna Charles Ekoh and Thankgod Nnanna Enewor

Article Type: Original Article | First Published: August 29, 2022

The liver plays a significant role in the maintenance of health and survival of an individual. Any threat to this important organ is a threat to the existence of life. Hence its protection is vital to survival. Individuals with SCD are at high risk of suffering from liver failure due to events resulting from HbS polymerization....

 Open Access DOI:10.23937/2469-5696/1410079

Correlation between Coagulation Tests Parameter with Padua Prediction Score in Covid-19 Patients at General Hospital of Prof. Dr. R. D. Kandou Manado

Masengi SJR, Lasut P, Hendratta C, Rotty LWA and Haroen H

Article Type: Original Article | First Published: July 29, 2022

Coronavirus disease 2019 (COVID-19) was associated with hypercoagulability state, some changes in parameter of coagulation tests, and also cause venous thromboembolism (VTE), which can be predicted with Padua Prediction Score (PPS). In this study, we are going to seek correlation of PPS and some parameter of coagulation tests between mild and moderate - severe COVID-19 patients in isolation room for COVID-19 patients at General Hospital of Prof. dr. R. D. Kandou Manado....

 Open Access DOI:10.23937/2469-5696/1410078

Hemophagocytic Lymphohistiocytosis in A Post Covid-19 Patient with Mds: A Case Report

Ioannis Vasilopoulos, MD, Marina P Siakantaris, MD, PhD, Kalliope Zerzi, MD, Eliana A Konstantinou, MD, John V Asimakopoulos, MD, PhD, Anestis Karapaschalidis, MD, Fotios Panitsas, MD, MSc, Eleni Plata, MD, Maria K Angelopoulou, MD, Theodoros P Vassilakopoulos, MD, PhD and Panayiotis Tsaftaridis, MD, PhD

Article Type: Case Report | First Published: July 13, 2022

Primary or secondary hemophagocytic lymphohistiocytosis (HLH) is characterized by immune activation and lifethreatening cytopenias. Causative relationship between a number of pathogens, autoimmune diseases and even hematologic malignancies with secondary HLH (sHLH) have been reported....

 Open Access DOI:10.23937/2469-5696/1410077

The Severity of Sickle Cell Anemia in Men - The Action of Molecular and Biochemical Markers

Jonathan de Oliveira Rios, Thais Fernandes Ribeiro, Gabriel Felipe Arantes Bertochi, Clarisse Lopes de Castro Lobo and Claudia Regina Bonini Domingos

Article Type: Original Article | First Published: June 23, 2022

Sickle cell disease is characterized by a very heterogeneous clinical course among patients with the same mutations for sickle cell hemoglobin (HbS). Sickle cell anemia (SCA) is a hereditary hemoglobinopathy caused by the homozygosity of a point mutation in the beta-globin gene, which leads to the substitution of glutamic acid for valine in the sixth position....

 Open Access DOI:10.23937/2469-5696/1410076

Clinical Presentations and Predictors of Severe Sickle Cell Disease among Patients Who Attended Muhimbili National Hospital Dar-Es Salaam, Tanzania: A Retrospective Study

Eunice Andrew Shija, Clement Kabakama, Benson Peter Mugaka, Yu-jiao Xiang1 and Yan Shi

Article Type: Original Article | First Published: May 04, 2022

Inherited hemoglobinopathies led by Sickle Cell Disease (SCD) are key contributors to the anaemia burden in Sub-Saharan Africa (SSA). In Tanzania, an estimated six out of one thousand newborns are born with SCD, making Tanzania the fourth country with the highest burden of SCD patients in the world and the third in Africa after Nigeria and the Democratic Republic of Congo (DRC) (Nigeria 85,000, Democratic Republic of Congo 42,000 and Tanzania 11,000). At present, curative options for sickle cell...

 Open Access DOI:10.23937/2469-5696/1410075

Applicability of the Neutrophil/Lymphocyte Ratio in Behavioral Studies

Romes Bittencourt Nogueira de Sousa, Luiz Henrique Alves, Vithoria Caetano Carmo, Cintia da Silva Manso, Fagner Medeiros Alves, Ana Gabriella Pereira Alves, Denise da Silva Pinheiro, Natália Carvalho de Camargo, Laura Carvalho de Camargo, Hully do Nascimento Segatti and Maria Sebastiana Silva

Article Type: Review Article | First Published: April 21, 2022

The balance of neutrophilic and lymphocytic populations in the body is sensitive to neuroendocrine changes present in acute and chronic emotional stress, influencing a range of behaviors intrinsically related to real or potential environmental stressors. In this sense, the Neutrophil/ Lymphocyte Ratio (NLR) is a simple and low-cost tool, derived from the analysis of the blood count, capable of showing changes in several health parameters, since it is related to the pro-inflammatory status of the...

 Open Access DOI:10.23937/2469-5696/1410074

Melphalan and Cytarabine as a Salvage Therapy in Children with Relapsed or Refractory Acute Leukemia

Malaval Carmen Isolde, MD, Queudeville Manon, MD, Döring Michaela, MD, Hartmann Ulrike, Dr. Pharm, Lang Peter, MD, Handgretinger Rupert, MD and Ebinger Martin, MD

Article Type: Research Article | First Published: March 16, 2022

In refractory or relapsed acute leukemia the achievement of a complete remission by a salvage therapy and the performance of allogeneic hematopoietic stem cell transplantation (HSCT) is in most cases the only treatment by which long term disease-free survival can be accomplished. With current salvage regimens a 5 year overall survival rate of 29% is obtained in children with relapsed acute myeloid leukemia (AML) and a 10 year overall survival rate of 36% in children with relapsed acute lymphobla...

 Open Access DOI:10.23937/2469-5696/1410073

Aplastic Anemia-Related Mortality in Brazil, 2000-2018

Augusto Hasiak Santo

Article Type: Case Report | First Published: January 14, 2022

Aplastic anemia (AA) is a rare and serious disease, potentially life-threatening, that affects hematopoietic stem and progenitor cells and is characterized by pancytopenia and a hypoplastic bone marrow. The development of AA result from the destruction of hematopoietic cells by three main mechanisms, including direct environmental injury, dysregulated immune system, and primary inherited or acquired bone marrow failure syndrome. There are no AA specific markers then the diagnosis is reached by e...

Volume 9
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