International Journal of

Blood Research and DisordersISSN: 2469-5696

Early Online

 Open Access DOI:10.23937/2469-5696/1410067

SMYD2 in Leukemia: An Update

Teresa Rubio-Tomás

Article Type: Mini-Review Article | First Published: August 30, 2021

SMYD2 is one of the five members (SMYD1-5) of the Su(Var)3-9, Enhancer-of-zeste and Trithorax (SET) and Myeloid, Nervy, and DEAF-1 (MYND) domain-containing (SMYD) protein family and is it known to methylate histone and non-histone substrates. By methylating a wide range of targets, SMYD2 acts as an oncogene in most cancer types. In this review I will comment on the last publications related to the role of SMYD2 in leukemia and I will refer to more extensive reviews if the reader aims to have a b...

 Open Access DOI:10.23937/2469-5696/1410066

Hypogonadotropic Hypogonadism in a Female Patient with Thalassemia Major

Richmond R Gomes

Article Type: Review Article | First Published: August 28, 2021

Thalassemia refers to a group of inherited diseases characterized by decreased or absent synthesis of normal globin chains. The direct consequence is an imbalance of the alpha and beta globin chain synthesis that results in anemia from ineffective erythropoiesis and hemolysis. The term thalassemia major refers to the severe form that is often associated with life-long transfusion dependent anemia. Hypogonadism is the most frequently reported endocrine complication, affecting 70-80% of thalassemi...

Volume 8
Issue 2