logo

   

Need a supporting hand in manuscript formatting? Write to our team.
Assistance in presubmission | editorialoffice@clinmedjournals.org

     
Clinical Medical
Image Library
ISSN: 2474-3682
IMAGE ARTICLE | VOLUME 1, ISSUE 1 | OPEN ACCESS DOI: 10.23937/2474-3682/1510001

Filarial Nematode that Induce Lymphatic Filariasis

Denis Voronin

Department of Radiology, Konya Training and Research Hospital, University of Health Science, Turkey

*Corresponding author: Denis Voronin, Molecular Parasitology, New York Blood Center, 310, East 67th Street, NYC, 10065. NY, USA, Tel: 212-699-5229, E-mail: DVoronin@NYBloodCenter.org

Published: May 20, 2015

Citation: Voronin D (2015) Filarial Nematode that Induce Lymphatic Filariasis. Clin Med Img Lib 1:001. doi.org/10.23937/2474-3682/1510001

Copyright: © 2015 Voronin D. This is an open-access content distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Parasite attacks its own symbionts. Elimination of Wolbachia, mutualistic endobacteria of filarial nematodes of medical and veterinary importance, by induction of authopahgy, parasite's intracellular defense mechanism.

The photo shows the direct connection of lysosomes (L) to Wolbachia-contained vacuole (W) without autophagosome formation during the induction of autophagy by RNAi specific treatment for Target of Rapamysin (TOR). Elimination of Wolbachia sterilizes filarial nematodes inducing apoptosis in developing embryos, decreases parasite's lifespan, and reduces the pathology of the infection (Figure 1). The new mode-of-action was discovered in the Liverpool School of Tropical Medicine (UK) to turn filarial parasites against its essential symbiont.

Figures