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Clinical Medical
Image Library
ISSN: 2474-3682
IMAGE ARTICLE | VOLUME 1, ISSUE 1 | OPEN ACCESS DOI: 10.23937/2474-3682/1510007

Drusen on Fire: Ex Vivo Hyperspectral Autofluorescence (AF) Image of Drusen from 81-Year-Old Male Donor with Age-Related Macular Degeneration

R. Theodore Smith , Tal Ben-Ami and Yuehong Tong

New York University, Department of Ophthalmology, Newyork, USA

*Corresponding author: R. Theodore Smith, New York University, Department of Ophthalmology, 550 First Avenue, New York, NY 10016, USA, Tel: 212-263-7300, E-mail: tbenami@gmail.com

Published: August 25, 2015

Citation: Smith RT, Ben-Ami T, Tong Y (2015) Drusen on Fire: Ex Vivo Hyperspectral Autofluorescence (AF) Image of Drusen from 81-Year-Old Male Donor with Age-Related Macular Degeneration. Clin Med Img Lib 1:007. doi.org/10.23937/2474-3682/1510007

Copyright: © 2015 Smith RT. This is an open-access content distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

The image is an overlay of 3 images representing the distribution of the 3 most abundant fluorophore signals that were extracted using advanced factorization algorithms. The 3 images were digitally colored red (1), green (2) and blue (3). The signals localized to different components in the RPE as illustrated by color mixing: normal RPE cells (light blue), RPE Cells stacked at the edge of drusen creating a halo effect (light green), main body of drusen (blue) with a distinct central signal (pink) that also localizes to sub-RPE deposits (red).This method demonstrates that distinct fluorophore signals are localized specifically to drusen in AMD tissues.