Parlak ES, Hezer H, Arguder E, Kilic H, Alisik M, et al. (2020) Serum Copeptin Levels in Obstructive Sleep Apnea. Int Arch Clin Pharmacol 6:022.


© 2020 Parlak ES, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

RESEARCH ARTICLE | OPEN ACCESSDOI: 10.23937/2572-3987.1510022

Serum Copeptin Levels in Obstructive Sleep Apnea

Ebru Sengul Parlak, MD1*, Habibe Hezer, MD1, Emine Arguder, MD1, Hatice Kilic, MD1, Murat Alisik, MD2, Gokhan Yalciner, MD3, Mehmet Ali Babademez, MD3, Ozcan Erel, MD4 and Hatice Canan Hasanoglu, MD1

1Department of Chest Diseases, Ankara City Hospital, Turkey

2Department of Clinical Biochemistry, Polatli State Hospital, Turkey

3Department of Otorhinolaryngology, Head and Neck Surgery, Ankara City Hospital, Turkey

4Department of Clinical Biochemistry, Ankara City Hospital, Turkey



To evaluate serum copeptin levels in patients with obstructive sleep apnea (OSA) and healthy controls.

Materials and methods

Fifty-eight newly diagnosed OSA patients and thirty-five healthy individuals were enrolled. OSA patients were divided into mild (5 ≥ AHI < 15), moderate (15 ≥ AHI < 30), and severe (AHI ≥ 30) groups. Copeptin levels were evaluated and compared between patients and healthy individuals. For the subgroup analysis, OSA patients were divided into two groups, AHI < 30 (mild-moderate) and ≥ 30 (severe) and copeptin levels were compared between the groups.


Copeptin levels were significantly higher in the OSA group compared to the healthy individuals (p = 0.001). In severe OSA patients (AHI ≥ 30), copeptin levels were significantly higher than in the mild-moderate group (p = 0.038). The analysis showed that copeptin levels > 4.41 had a 89% sensitivity and 71% specificity for APE (AUC 0.831, 95% CI 0.740-0.922).


Serum copeptin levels were found to be associated with OSA, severe OSA. Copeptin levels may be useful for monitoring and determining high-risk patients OSA patients.