Seventy-one patients (71) with chronic kidney disease (CKD) (21 men and 18 females non-treated with hemodialysis and 19 men, respectively 13 females treated with regularly repeated hemodialysis) are investigated. The mean clearance of creatinin in investigated group were 0.17 mL/sec (10.2 mL/min). The average age of non-dialyzed group were 40.3 years, and in the dialyzed patients -38.6 years.
The transfixant iliac bone biopsy is commit in two patient's group (non-demineralized sections; Goldner coloration). The electronic pencil with "on line" computer connection ("Apple") is utilized for measurement of trabecular bon mass and the volume of howship lacunes (HL). The number and volume of HL is correlated with the blood concentration of c-iPTH and CT. The mean value of the proportion: "volume of the HL/trabecular bone mass "(%) in non-dialyzed patients is 0.01%, and in dialyzed group = 0.008% (the difference is statistically non significant). The correlation between the immunoreactive "C" peptide of parathormon (c-iPTH) and HL's volume in non-dialyzed patient's group is non-significant too (r = NS), but in the dialyzed subjects, it is negative (r = -0.31).
However, the relationship between the plasma concentration of calcitonin (CT) and the volume of HL is reciprocal in two groups of investigated patients (r1 = -0.51; r2 = -0.10).