Today, tobacco is the common form used for smoking. Worldwide, tobacco consumption is estimated to kill 1,000 million in the 21st century. Persons with mental illness consume about 33% of the tobacco used and nearly 46 million adults with mental illness have a smoking rate 70 percent higher than those without. Admission to the hospital provides an excellent opportunity for patients to quit smoking. A good knowledge of the hazards of smoking and cessation intervention alone is not adequate for a nurse, but a positive attitude and high self-efficacy are two eyes to provide a better practice. A cross-sectional descriptive study was done to assess nurses' attitude and self-efficacy which showed that the mean and SD was 29.3 ± 5.698 and 35.87 ± 5.883 respectively; 17 (21%) and 64 (79%) subjects had negative and positive attitude respectively; 16 (19.8%) and 65 (80.2%) subjects had less and more self-efficacy respectively. When the two domains (gender and smoking status of the subjects) were associated with experience at Centre for Addiction Medicine (CAM) unit using chi-square test, the study participants possessed a positive attitude and more self-efficacy irrespective to the associated variables. However, subjects with experience at the Centre for Addiction Medicine (n = 27), females (n = 19) and non-smokers (n = 78) scores were comparatively high. Fortunately, there was a significant score (χ² = 3.894, p = 0.048) in the self-efficacy of the subjects who had experience at Centre for Addiction Medicine. The study also revealed that the higher the attitude on smoking cessation care, higher the self-efficacy (r = 0.674, p = 0.001) among the nurses.