CASE REPORT | VOLUME 4, ISSUE 2 | OPEN ACCESS DOI: 10.23937/2572-3308.1510033

A Case of SLE that Healed Completely after Ten Intradermal Injections with a Non-Specific Antigen Preparation

Kimihiko Okazaki*

Okazaki Medical Clinic, Ukyoku Kyoto, Japan

*Corresponding author: Kimihiko Okazaki, Okazaki Medical Clinic, Ukyoku Kyoto, Japan.

Accepted: August 11, 2018 | Published: August 13, 2018

Citation: Okazaki K (2018) A Case of SLE that Healed Completely after Ten Intradermal Injections with a Non-Specific Antigen Preparation. Int J Aller Medications 4:033.

Copyright: © 2018 Okazaki K. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


According to the traditional concept of the contemporary Immunology, neither autoimmune diseases nor allergic diseases can be cured completely. Nevertheless, a fortunate coincidence led the author to discover a novel concept that eliminations of the causes of these diseases are possible. In other words, combinations of pathogenic antibodies with responsible cells, namely, cytolytic T lymphocytes in cases of autoimmune diseases and mast cells in cases of allergic diseases, can be decomposed by replacing the pathogenic antibodies with non-specific antibodies. In more detail, intradermal injections with a non-specific antigen preparation induce productions of non-specific antibodies in the body of the patient. Repetitions of the injections bring about an accumulation of them. Accumulated non-specific antibodies will occupy most of the receptors on the surface of responsible cells. When the accumulation reaches the sufficient level, virtually no pathogenic antibodies would remain on the receptors. That is, no causes of the diseases remain.

It is well established that the etiology of allergic diseases is that combinations of mast cells and allergen-specific antibodies cause allergic symptoms when the patients meet allergens. Similarly, the etiology of auto-immune diseases is that combinations of cytolytic T lymphocytes and organ-specific antibodies cause injury of the organ. A most plain idea would be that break down of the above-mentioned combinations must bring about disappearance of causes of the diseases. To work out the above mentioned concept, it is necessary to have the patients make non-specific antibodies for themselves. In order for the patients to do so, they need to receive intradermal injections with non-specific antigen preparations. Consequently, non-specific antibodies accumulate in the patients' bodies, which may replace specific antibodies from respective cells bringing about elimination of causes of the diseases. Needless to mention, where there is no cause, there is no disease. Details are demonstrated elsewhere [1]. The conceptual basis of antibodies' mutual exchange is existence of equilibrium state among antibody molecules in the vicinity of receptors, which was first proposed by Porter [2]. One of the contemporary trends concerning treatments of allergic diseases is an intravenous infusion of solution of non-specific antibody preparation. However, a large number of these infusions are dangerous because anti-antibody antibody might be produced in the recipient's body, which may cause an anaphylactic reaction.

Case 1

A 63-year-old woman (M.O.) visited the author's clinic on April 21, 2011. She said that she had suffered from a systemic urticaria including conjunctivitis and rhinitis in the middle of May of 1987. She did not get better at a local clinic. She was diagnosed at The Osaka Medical School Hospital as SLE (systemic lupus erythematosus) after examinations including that of the bone marrow. She was treated with daily 40 mg of Prednisolone for 3 months, kept daily dose of 10 mg as a maintenance dose after several months of gradual decrease in the daily dose. At the author's clinic, she receive an intradermal injection with 0.1 ml of 1,000,000 fold with saline diluted Neurotropin; a product of Nippon Zohki Pharmaceutical Company (Osaka), consisting of an extract of rabbit skin inflamed by inoculation of Vaccinia virus, at her upper arm at 2~19 day intervals 18 times during the period from April 21, 2011 until August 25, 2011. As of April 13, 2018, she is enjoying a healthy life.


  1. Okazaki K (2009) Therapeutic significance of non-specific antigens as anti-allergic and anti-autoimmune agents. Pharmacometrics 76: 105-107.

  2. Porter RR (1959) The hydrolysis of rabbit gamma-globulin and antibodies by crystalline papain. Biochem J 73: 119-126.