REVIEW ARTICLE| VOLUME 3, ISSUE 2 | OPEN ACCESS DOI: 10.23937/2572-3235.1510030

The Key Role of Multislice Computed Tomography for Direct Aortic Trans-catheter Aortic Valve Implantation

Giuseppe Bruschi1*, Fesc Paola Colombo1, Bruno Merlanti1, Diana Artioli2, Stefano Nava1, Francesco Soriano1, Oriana Belli1, Francesco Musca1, Luca Botta1, Giuseppe Tata1, Ettore Colombo2, Fabrizio Oliva and Claudio F Russo1

1"De Gasperis" Cardiac Center, Niguarda Metropolitan Hospital, Milan, Italy

2Department of Radiology, Niguarda Metropolitan Hospital, Milan, Italy

*Corresponding author: Giuseppe Bruschi, "De Gasperis" Cardiac Center, Niguarda Metropolitan Hospital, Piazza dell'Ospedale Maggiore 3, 20162 Milan, Italy, Tel: +39-02-6444-2565, Fax: +39-02-6444-2566.

Accepted: December 28, 2017 | Published: December 30, 2017

Citation: Bruschi G, Colombo FP, Merlanti B, Artioli D, Nava S, et al. (2017) The Key Role of Multislice Computed Tomography for Direct Aortic Trans-catheter Aortic Valve Implantation. Int J Radiol Imaging Technol 3:030.

Copyright: © 2017 Bruschi G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Transcatheter Aortic Valve Implantation (TAVI) has been designed to treat elderly patients with severe aortic stenosis considered high-risk surgical candidates. The safety and effectiveness of TAVI have been demonstrated in numerous studies.

Retrograde femoral implantation is considered the less invasive approach for TAVI, however TAVI patients are also often affected by severe iliac-femoral arteriopathy, rendering the trans-femoral approach either unemployable or are deemed to carry a high risk of vascular injury.

Different arterial alternative access site has been used to implant transcatheter bioprosthesis, the subclavian, the ascending aorta and the carotid artery and more recently.

In the present report, we present indication and contraindication to direct aortic approach and we analyzed the key role of computed tomography.


Catheter-based valve intervention, Aortic stenosis, Structural heart disease, Transcatheter technique, Multislice computed tomography


Severe Aortic Stenosis (AS) is the most frequent form of valvular heart disease in western countries and a major cause of cardiovascular morbidity and mortality in the elderly. Symptomatic aortic stenosis has become an increasing health problem with a prevalence of 5% in patients over the age of 75 years [1,2].

Transcatheter aortic valves have been designed to treat patient affected by severe Aortic Stenosis (AS) deemed high risk for standard Aortic Valve Replacement (AVR). In fact, even if aortic valve replacement is the standard treatment for patients affected by AS [3], one third of patients, affected by severe aortic stenosis, may have been denied surgery [4]. This is related to the fact that the mortality rate associated with AVR increases substantially if multiple comorbidities are present such as: Significant left ventricular dysfunction, previous chest surgery or radiation, chronic obstructive pulmonary disease, liver or renal failure [5].

Since the first human percutaneous aortic valve implantation successfully performed by Cribier, et al. in 2002 more than 250,000 patients underwent TAVI worldwide with the two first CE mark trans-catheter aortic valve, the balloon-expandable Edwards SAPIEN prosthesis (Edwards Life sciences, CA, USA) and the self-expandable Medtronic Core Valve Revalving prosthesis (Medtronic Inc, MN, USA). A substantial body of data exists in relation to the clinical outcome of TAVI from post-marketing registries, observational clinical studies and National Registries [6-8] but and also form controlled randomized trial [9-11].

At the beginning of the experience the only access was the retrograde approach from the common femoral artery [12,13]. It must be considered that the trans-femoral approach requires favorable ileo-femoral arterial anatomy; this approach is contraindicated in patients with small size, severe calcifications and atherosclerosis of ileo-femoral arteries. To treat these patients a transapical approach with the Ascendra transapical catheter and the Edwards-Sapien valve was proposed [14]. However, this approach is more invasive since it requires direct Left Ventricle (LV) apex surgical exposure. Moreover, the transapical approach requires a dedicated antegrade delivery system. Since 2008 different alternative arterial access have been described, and received CE mark approval, for TAVI implantation in patient not suitable for peripheral femoral approach, the subclavian artery [15] and the direct aortic access [16,17]. More recently also a trans-carotid [18] and access has been describe [19].

Direct Aortic Approach

The procedure should be performed preferably in a hybrid operating room, with transesophageal echocardiographic and fluoroscopic guidance. To perform the operation, a multidisciplinary team involving interventional cardiologist, cardiac surgeon with expertise in hybrid procedure and wire skills, and is required.

The procedure is performed under general anesthesia, a double lumen endotracheal tube should be used for single left lung ventilation. A temporary pacing lead is advanced in the right ventricle through the femoral or jugular vein in patients without permanent pace-maker, to treat possible post-TAVI atrioventricular block. The radial artery or the best femoral artery is accessed by a single wall puncture under fluoroscopic guidance, to allow monitoring during the procedure and landmark aortic angiography through a 6-Fr pigtail. Heparin is administered to maintain an activated clotting time of > 250 s throughout the procedure. Procedural details have been previously described [17,20-22]. The procedure should be performed through a right anterior mini-thoracotomy or through an upper mini sternotomy.

The Role of Multislice Computed Tomography

Trans-catheter candidates usually underwent as standard screening protocol, transthoracic echocardiogram, complete left heart catheterization, and coronary angiography, moreover all performed also chest and aortic-iliac-femoral computed tomography scan.

Multislice Computed Tomography (MSCT) is playing an increasingly important role in patient screening protocols before TAVI, provides detailed anatomic assessment of the aortic root and valve annulus assesses the suitability of iliofemoral access, and determines appropriate coaxial angles to optimize the valve implantation procedure. At minimum, an MSDCT scanner with 64-detectors technology is recommended for image acquisition. The specific scan protocols used for TAVI assessment vary, but typically include imaging of the entire aorta including the aortic root, thoracoabdominal aorta, and iliofemoral arteries. Because of the cyclic motion of the aortic valve, root, and ascending aorta, ECG-synchronized imaging of the root is critical to avoid image degradation secondary to motion artifacts. Two-options to achieve synchronization to the ECG are available, retrospective gating and prospective triggering. ECG-synchronization with retrospective gating acquires CT data throughout the entire cardiac cycle, and subsequently reconstructs images gated to a specific phase of the cardiac cycle. Alternatively, ECG-synchronization can be achieved with prospective triggering, which is associated with significantly lower radiation exposure [23].

On the basis of multislice computed tomography it is possible to evaluate:

- Ileo-femoral anatomy, vessel size, tortuosity and calcifications (Figure 1).

Figure 1: 3-d MSCT reconstruction allows to evaluate ileo-femoral anatomy, tortuosity and calcifications. View Figure 1

- Valve anatomy (bicuspid, tricuspid) location and degree of valve calcifications as well as annulus perimeter to choose the right TAVI size (Figure 2).

Figure 2: Double oblique transverse reconstruction of the aortic root below the commissural insertion of aortic valve allows to evaluate annulus size (perimeter, diameter). View Figure 2

- Ascending aorta anatomy, presence and location of calcification, root angulation (Figure 3).

Figure 3: 3-d MSCT reconstruction of ascending aorta allows to evaluate ascending aorta anatomy, presence and location of calcification. View Figure 3

- Coronary height and the relationship between leaflet height and distance between annulus and coronary ostia, which identifies patients at risk for coronary occlusion during the TAVI procedure.

- In case of patient that underwent prior myocardial revascularization, the location of proximal graft anastomosis and location of internal mammary artery grafts (Figure 4).

Figure 4: 3-d MSCT reconstruction of ascending aorta allows to evaluate the location of proximal graft anastomosis and location of internal mammary artery grafts. View Figure 4

- Evaluate coaxial trajectory from entry site on the ascending aorta to aortic annulus (Figure 5).

Figure 5: Multislice computed tomography allows to evaluate coaxial trajectory from entry site on the ascending aorta to aortic annulus in case of direct aortic approach. View Figure 5

- Moreover, on the basis of pre-operative MCT it is possible to consider if right anterior mini-thoracotomy or upper-mini-sternotomy is more convenient for valve implantation (Figure 6).

Figure 6: Cross-section image at the level of second costal cartilage allows to choose, in case of direct aortic approach, between right anterior thoracotomy or upper mini-sternotomy. Yellow line is drawn at the right edge of the sternum to determine percentage of aorta to its right; A) Example of a case suitable for right anterior thoracotomy; B) Example of a case suitable for mini-sternotomy. View Figure 6

- Predict appropriate angle of deployment for trans-catheter valve implantation.


Since the first case of a successful transcatheter implantation of an aortic bioprosthesis made by Cribier, et al. in April 2002 done via the femoral vein with an antegrade (trans-septal) access, trans-catheter aortic valve implantation has been successfully adopted in hundreds of centers across the world and more than 200,000 patients affected by severe aortic stenosis have been treated. The only access site during the initial phase was the femoral approach but during the years several different access routes have been developed (transapical, subclavian) and successfully adopted in many centers.

The subclavian/axillary approach was the first alternative approach that gained CE mark approval for CoreValve implantation on December 2010. Trans-subclavian/axillary approach has the advantage that axillary artery is easily accessible after surgical cut-down and that the procedure should be performed with local anesthetic and mild sedation. However the axillary is a fragile artery and patients are not eligible for the subclavian approach in case of vessel diameter < 6 mm, heavy calcification, excessive tortuosity, or tight subclavian stenosis not amenable to percutaneous balloon angioplasty [24-26]. Moreover, the subclavian approach has to be considered cautiously in patients with patent left internal mammary artery graft.

Direct aortic approach gained CE mark on November 2011, is theoretically more invasive as compared to axillary approach, requiring a mini-thoracotomy or upper mini-sternotomy. The advantage is that no limitation in vessel size is present and in severe horizontal aorta the procedure is feasible.

Direct aortic TAVI should be considered either a mirror image of the transapical procedure or a trans-femoral procedure through the aorta, with the special advantages of high control of valve deployment with no adverse effect on the left ventricle structure or function. Exposure of the aorta is a common skill for a cardiac surgeon; moreover, the majority of open heart operations are performed with cannulation of the aorta within two purse-string sutures, like in direct-aortic. For TAVI, the surgeon must be trained in the principles of catheterization techniques such as the Seldinger technique, wire exchanges and maintaining wire positions, shifting his focus from the surgical field to the imaging screen [27,28].

The advantage of performing the implantation through a right anterior mini-thoracotomy is more evident in re-do patients, in whom a repeat sternotomy, even if partial, is a challenging procedure; indeed, right thoracotomy requires only limited dissection at the entry site on the ascending aorta and is feasible also in patients with patent venous grafts' proximal anastomosis on the ascending aorta [29].

This approach allows TAVI deployment to truly avoid the aortic arch contact, as there is neither a delivery system nor a wire placement in the arch, avoiding the risk of dislodging atherosclerotic plaque during valve passage, this may translate into lowering the incidence of stroke. The only contraindications for this approach are a complete porcelain aorta where there is presence of calcium at entry side zone and when the ascending aorta is not accessible.

All non-iliofemoral and proximal arterial accesses had the advantage of overcoming challenging aorto-ileo-femoral vascular disease, and avoids the risk of dislodging atherosclerotic plaque during valve passage through the aorta. The control of the delivery system is dramatically enhanced because any force is directly transmitted one-to-one without any loss of pushability and tractability compared with a TF approach. A co-axial trajectory to the aortic valve plane allows a perfect alignment of the TAVI device in the aortic annulus. This undoubtedly facilitates more accurate valve deployment, which might be particularly useful in patients with complex anatomical or pathophysiological conditions (horizontal ascending aorta, large annular sizes and primary aortic regurgitation) [22,27,28].

Multislice computed tomography has assumed an increasingly important, complementary role before and after TAVI, and provides detailed anatomic assessment of the aortic root structures and iliofemoral access, adding to the information obtained with echocardiography and angiography. Therefore routine screening with MSCT is utilized by several groups to evaluate TAVI patients, and it is mandatory in patients evaluated for a direct aortic approach to improve the safety and potential application of TAVI in the management of symptomatic aortic stenosis patient considered high risk for surgery.


Dr. G. Bruschi is consultant for Medtronic and St. Jude-Abbott.


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