Tocia C, Alexandrescu L, Șuța VC, Dumitru E (2019) Inflammatory Bowel Diseases (IBD) - Associated Spondyloarthropathy in the Biologic Era: A Case Series. J Clin Gastroenterol Treat 5:065.


© 2019 Tocia C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

CASE SERIES | OPEN ACCESS DOI: 10.23937/2469-584X/1510065

Inflammatory Bowel Diseases (IBD) - Associated Spondyloarthropathy in the Biologic Era: A Case Series

Cristina Tocia, MD1,2, Luana Alexandrescu, MD1,2*, Victoria Cristina Șuța, MD1,2 and Eugen Dumitru, MD1,2

1Faculty of Medicine, Ovidius University of Constanța, Romania

2County Clinical Emergency Hospital of Constanța, Romania


Articular manifestations are the most common extraintestinal manifestations in inflammatory bowel diseases and are classified into axial spondyloarthritis (SpA) and peripheral SpA. EIM may occur before or after IBD diagnosis, being the proof that IBD is not only limited to gut. Here we present a case series of three patients with Crohn's disease and extraintestinal manifestations admitted to our hospital. Patients had in common young age, Crohn's disease with moderate or severe clinic and endoscopic activity, axial spondyloarthropathy and some particularities: One case associated type 1 peripheral arthritis, another case type II peripheral arthritis with enthesitis and oral aphtous ulcers and the last case associated uveitis and erythema nodosum. After failure of conventional therapy, treatment with TNF-inhibitors was initiated and remission was achieved. These case reports highlight the importance of TNF inhibitors, this therapy being currently the only effective treatment for patients with aggressive disease, associated SpA or who failed to respond to conventional therapy.