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Journal of
Infectious Diseases and Epidemiology ISSN: 2474-3658

Citation

Miglietta F, Palumbo C, Parente F, Velardi L, Matera R, et al. (2019) Intraleukocytic Yeast Inclusions and Toxic Granulation Neutrophils on Peripheral Blood Smear: An Interesting Synergy between Hematology and Microbiology. J Infect Dis Epidemiol 5:067. doi.org/10.23937/2474-3658/1510067

Copyright

© 2019 Miglietta F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

CASE REPORT | OPEN ACCESS DOI: 10.23937/2474-3658/1510067

Intraleukocytic Yeast Inclusions and Toxic Granulation Neutrophils on Peripheral Blood Smear: An Interesting Synergy between Hematology and Microbiology

Fabio Miglietta1, Claudio Palumbo1, Fernando Parente2, Luciano Velardi3, Rosella Matera4, Luigi Conte4, Michela Dargenio4, Maurizio Quarta5, Milva Maria Nuzzo5, Nicola Di Renzo4 and Giambattista Lobreglio6

1Laboratory of Microbiology, Vito Fazzi Regional Hospital, Lecce, Italy

2Medicine Unit, Vito Fazzi Regional Hospital, Lecce, Italy

3Istituto di Nanotecnologia, CNR-Nanotec, Bari, Italy

4Department of Hematology, Vito Fazzi Regional Hospital, Lecce, Italy

5Infectious Diseases Unit , Vito Fazzi Regional Hospital, Lecce, Italy

6Laboratory of Clinical Pathology, Vito Fazzi Regional Hospital, Lecce, Italy

Abstract

The presence of yeast neutrophil inclusions was observed and discussed several times in other reports; moreover some works demonstrated how Toxic Granulation Neutrophils (TGNs) are especially helpful in predicting acute bacterial infection, while the development of candidaemia-related TGNs was rarely described and in-depth.

We describe two occasional findings of neutrophil inclusions and marked TGNs respectively due to Candida tropicalis and Candida guillermondi on peripheral blood smear.

We proved how the microscopic observation of marked toxic granulations can afford to suspect a systemic microbial infection without the potential to discriminate between bacterial or fungal infections.