Ben HKA, Tuoni C, Ciantelli M, Di Marco S, Ghirri P (2019) Implication of Enteric Viruses in the Digestive Surgical Pathologies in Tunisian Children. J Infect Dis Epidemiol


© 2019 Ben HKA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

RESEARCH ARTICLE | OPEN ACCESS DOI: 10.23937/2474-3658/1510091

Implication of Enteric Viruses in the Digestive Surgical Pathologies in Tunisian Children

Ben Haj Khalifa A1,2*, Jerbi A2,3 and Trabelsi A2,3

1Laboratory of Microbiology, Hospital Tahar Sfar, Tunisia

2Research laboratory (LR 14 SP 02) Immunogenetics Laboratory of Epidemiology of Human viral infections, Hospital Sahloul, Tunisia

3Laboratory of Microbiology, Hospital Sahloul, Tunisia



Recent virological studies have shown the association between digestive diseases and some enteric viruses: adenovirus, rotavirus, enterovirus, .... Our objectives were to show the impact of viral infections of the digestive complications and interactions between enteric viruses and digestive tract cells.


During the period 2010-2011, the tissue samples preserved in paraffin obtained after reduction surgery in children hospitalized for digestive diseases (appendicitis, IIA, BA, peritonitis) in the pediatric surgery department of the CHU Fatouma Bourguiba, Monastir, Tunisia. Enteric viruses were detected by PCR of rotavirus, genotyping by RT-semi-nested multiplex PCR.


During the study period, 64 samples were collected from children with gastrointestinal surgical pathologies. The AdV were detected in 9 cases (14%) and rotavirus in 1 case (1.5%). A male predominance was observed, with a sex ratio of 1.9. The age ranges from 1 day to 8 years. The child found positive in rotavirus was among have 5-months-old and had an array of ileo-IIA Cecile. Children detected positive in adenovirus were aged 2 months to 7 years. All subjects had surgical treatment with systematic appendectomy.


To our knowledge this is the first study carried out in our country etiology. About viral etiology of these diseases in our study, adenovirus was present in 13% of children and involved in 20% of children with acute appendicitis, rotavirus was found in one child invaginated.