Mastroianni A, Greco S, Vangeli V, Mauro MV, Manfredi R (2023) Acute Thyroiditis Complicating a Systemic Parvovirus B-19 Infection: A Unique Adult Case Report in Italy and Literature Review. J Infect Dis Epidemiol 9:297.

Letter to the Editor | OPEN ACCESS DOI: 10.23937/2474-3658/1510297

Acute Thyroiditis Complicating a Systemic Parvovirus B-19 Infection: A Unique Adult Case Report in Italy and Literature Review

Antonio Mastroianni, MD1*, Sonia Greco, MD1, Valeria Vangeli, MD1, Maria Vittoria Mauro, MD2 and Roberto Manfredi, MD3

1Infectious & Tropical Diseases Unit, "Annunziata" Hub Hospital, Cosenza, Italy

2Microbiology & Virology Unit, Annunziata Hospital, Cosenza, Italy

3Infectious Diseases Institute, Alma Mater Studiorum University of Bologna, Bologna, Italy


Acute thyroiditis, Adult, Parvovirus B 19 infection, Virus-induced autoimmune disorders, Graves-Basedow disease

The etiopathogenetic link between Graves' disease, COVID-19 and vaccination is of current and intriguing importance [1]. A very rare case of acute Graves-Basedow adult disease prompted by a systemic Parvovirus B-19 infection is presented and discussed, on the basis of the most recent literature evidences in this field. Parvovirus B19 is a small virus parasiting erythrocytes frequently underestimated in clinical practice, when excluding patients with severe hematological diseases [1]. A cutaneous rash involving upper extremities, polyarthralgia, and the association with the chronic fatigue syndrome have been described in otherwise immunocompetent subjects.

A 40-year-old previously healthy male was hospitalized through the Emergency Room of our Hospital because of hyperpyrexia, chills, tachycardia, a diffuse significant polyarthralgia of small joints, and the subsequent appearance of a cutaneous rash involving upper limbs. The patient also complained of diarrhoea, restlessness, especially during the night with sleep disturbances and tremors. Concurrently, an acute severe thyroiditis appeared (Graves-Basedow disease), treated with corticosteroids, thiamazole and a beta-blocker. A frankly positive anti-Parvovirus IgM and IgG serology accompanied a very elevated Parvovirus B19 viremia (139,000 copies/mL), thus confirming the systemic Parvoviral infection. As a part of a periodic laboratory screening, thyreotropin and thyroideal hormone levels were performed. Moreover, a few months before hospitalization our patient performed an endocrinological assessment at a public endocrinological service of our city due to a persistent infertility issue, which excluded any endocrinological-thyroideal problem. Upon admission, very high free thyroxine levels (77.7 ng/L), completely suppressed TSH levels, elevated anti-thyroid peroxidase antibodies (342 KUI/L), intensely positive anti-TSH receptor antibodies (> 40 U/L, together with positive serum anti-thyroglobulin antibodies (1,232 KUI/L), confirmed the diagnosis of autoimmune thyroiditis. All other microbiological assays tested negative for EBV, CMV, HBV, HCV, HIV, HTLV-I, SARS-CoV-2 and other pathogens, while a full laboratory workup for all searchable autoimmune diseases also proved negative. A neck ultrasonography showed a thyroideal gland of increased volume with dyshomogeneous structure and a diffusely increased vascularization, as for an acute thyroiditis, in the absence of neck adenopathies and thyroid nodules. Parvoviral detection in the gland tissue was not available at our teaching Hospital, while this invasive procedure was deemed unreasonable in a real life context, where an etiologic treatment for Parvovirosis is not available. The subsequent monthly follow-up did not disclose complications, save a mild and self-limiting skin rash, probably due to thiamazole. Residual hypothyroidism was ruled out after a prolonged endocrinological monitoring. We hypothesized that parvovirus infection triggered a thyroid autoimmune response that caused hyperthyroidism, similarly to what was reported for EBV infection as well as HIV and HTLV-I.

Prolonged viral infections represent a known trigger for autoimmune-related disorders, with HCV, HBV and EBV as the major determinants of Hashimoto thyroiditis [2], apart from recent observations regarding the potential role of SARS-CoV-2, too [3]. Several reports discussed about the emerging role of Parvovirus B19 in the setting of acute thyroiditis especially in children, while adult cases are not represented until now, as to the best of our knowledge. A long-term persistence of Parvovirus B19 together with the continued expression of Parvovirus antigens in non-erythroid tissues may play a key role in triggering autoimmune diseases like thyroiditis. In parallel, the progress of all diagnostic virological testing potentially allow a direct Parvovirus detection in tissues, thus improving current diagnostic tools available on thyroid specimens, too. The wise observation regarding the questioned role of viral infection in autoimmunity remains extremely up-do-date: the pathogenetic association between autoimmune disorders and a prolonged Parvovirus B19 infection deserves in -depth investigation, and further clinical description. In conclusion, our report of an acute thyroiditis during a documented, systemic Parvovirus B19 infection in adulthood adds significantly to the present knowledge. We suggest it is reasonable to routinely assess the thyroid functions both in the acute phase and during the convalescence of Parvovirus B19 infection. Human parvovirus B19 may be a candidate virus for environmental factors determinant for the appearance of autoimmune thyroid diseases (AITD) in susceptible subject and the exact relationship between Parvovirus B19 and thyroid disorders needs to be more extensively investigated.





Conflicts of Interest


Patient's Consent

A signed informed consent for publication was obtained, and the manuscript is in accordance with the institution's ethics committee.


  1. Famularo G, Baldelli R (2022) Graves' disease, COVID-19, and vaccination. Minerva Endocrinol (Torino) 47: 476-477.
  2. Fallahi P, Ferrari SM, Vita R, Benvenga S, Antonelli A (2016) The role of human parvovirus B19 and hepatitis C virus in the development of thyroid disorders. Rev Endocr Metab Disord 17: 529-535.
  3. Muller I, Cannavaro D, Dazzi D, Covelli D, Mantovani G, et al. (2020) SARS-CoV-2-related atypical thyroiditis. Lancet Diabetes Endocrinol 8: 739-741.


Mastroianni A, Greco S, Vangeli V, Mauro MV, Manfredi R (2023) Acute Thyroiditis Complicating a Systemic Parvovirus B-19 Infection: A Unique Adult Case Report in Italy and Literature Review. J Infect Dis Epidemiol 9:297.