Citation

Hossain MF, Rashid M, Burniston T, Wu MAW, Kataye KA, et al. (2019) Evaluation of Fucoxanthin Content in Popular Weight Loss Supplements: The Case for Stricter Regulation of Dietary Supplements. J Obes Weight-Loss Medic 5:031. doi.org/10.23937/2572-4010.1510031

Copyright

© 2019 Hossain MF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

ORIGINAL RESEARCH ARTICLE | OPEN ACCESS DOI: 10.23937/2572-4010.1510031

Evaluation of Fucoxanthin Content in Popular Weight Loss Supplements: The Case for Stricter Regulation of Dietary Supplements

Mohammad Faisal Hossain*, Mamoon Rashid, Thomas Burniston, Mohammed Ahmed, Winnie Wu, Kolawole Adeshina Kataye, Rajjit Sidhu, Michael Justice and Shamly Abdelfattah

Appalachian College of Pharmacy, Oakwood, USA

Abstract

Misbranded and counterfeit dietary supplements have been an issue on which the US Food and Drug Administration has been vigilantly regulating. The ubiquity of online-shoppable weight-loss supplements and their unrestricted consumption by obese people are serious matters of concern. Fucoxanthin, a brown-seaweed-extracted carotenoid has exhibited anti-obesity property in some clinical trials through its ability to over express uncoupling protein (UCP1) in the white adipose tissue, which leads to fat burning. However, since the clinical trials apply pure fucoxanthin instead of fucoxanthin-bearing dietary supplements, a critical analysis is warranted to quantify fucoxanthin in brown seaweeds to validate their rationale in weight loss mechanism. This study examined ten randomly chosen online-sourced brands of fucoxanthin-containing dietary supplements and analyse the content using High-Performance Liquid Chromatography (HPLC) equipped with UV-Vis and photodiode array detector. Our exploration revealed that, of these 10 products, 3 (30%) did not have any detectable quantity of fucoxanthin, 5 (50%) contained only trace amount of it, ranging from 0.001-0.01 mg per capsule, and only 2 (20%) products contained 0.4 mg or 2 mg of fucoxanthin, meeting their label claim. This worrying finding may be interpreted that the existing ease-of-access and pervasive nature of online-sourced dietary supplements require more stringent regulatory screening.