Clinical Medical

Reviews and Case ReportsISSN: 2378-3656

Current Issue

 Open Access DOI:10.23937/2378-3656/1410237

Low Saturation Readings in a Patient with Congenital Methemoglobinemia Exposed to Patent Blue Dye: A Case Report

Claudia Jong Chie TIEN and Priscilla Hui Yi PHOON

Article Type: CASE REPORT | First Published: September 29, 2018

Pulse oximetry is widely used perioperatively to detect respiratory events. Abnormal haemoglobins such as methemoglobin can result in inaccurate readings. Here we present the clinical challenges of managing a patient with congenital methemoglobinemia who went for surgery involving injection of patent blue dye and subsequently had a prolonged duration of poor saturation readings post-operatively. Differentials include desaturation due to respiratory causes, worsening of methemoglobinemia and dela...

 Open Access DOI:10.23937/2378-3656/1410236

Transfer Factor Revisited: Treatment of Chronic Mucocutaneous Candidiasis in a Child with Autoimmune Polyendocrinopathy Syndrome Type-1

J Kelly Smith

Article Type: CASE REPORT | First Published: September 15, 2018

A 5-year-old boy was diagnosed as having chronic mucocutaneous candidiasis at the age of three months. He showed no improvement despite treatment with two courses of intravenous amphotericin B, 2½ years of oral 5-fluorocytosine, and daily treatment with topical Mycostatin. An immune assessment revealed that he was anergic and had low levels of circulating FCγR+ monocytes. Buccal smears revealed numerous candida and no inflammatory response. On treatment with transfer factor his FCγR+ monocyte...

 Open Access DOI:10.23937/2378-3656/1410235

Painless Thyroiditis Induced by Immune Checkpoint Inhibitors in a Patient with Small Cell Lung Cancer

Maria Jose Burches Feliciano, Antonia Perez Lazaro and Juan Francisco Merino Torres

Article Type: CASE REPORT | First Published: September 14, 2018

New antineoplastic agents consisting of specific monoclonal antibodies which enhance the host's immune response against the tumoral cells are becoming more common in clinical practice. Ipilimumab, an antibody that blocks the cytotoxic T-lymphocyte antigen 4 (CTLA-4), and nivolumab, a programmed cell death 1 (PD-1) inhibitor are now approved for several advanced neoplasias such as melanoma, non-small cell lung cancer and renal cell carcinoma....

 Open Access DOI:10.23937/2378-3656/1410234

Fatal Side Effect of Treprostinil - Hypoglycemia: A Case Report

Dongling Luo, Caojin Zhang and Yigao Huang

Article Type: CASE REPORT | First Published: September 12, 2018

Treprostinil is generally safe and efficacious prostacyclin analog that is recommended for patients with NYHA class III/IV pulmonary hypertension. The reported side effects of standard dosing of treprostinil include fatigue, facial flush, headache, chest pain, dyspnea, right ventricular heart failure and pallor. Other side effects include abdominal cramping, diarrhea, jaw pain, edema, vasodilation and nausea [1]. Hypoglycemia as a side effect of treprostinil is extremely rare. We report the firs...

 Open Access DOI:10.23937/2378-3656/1410233

Consecutive Successful Pregnancies after Conservative Management of Early Stage Endometrial Carcinoma

Chia-Chi Yen, Chieh-Yi Kang, Hsing-Chun Tsai, Ming-Ting Chung, Meng-Chen Tsai and Yung-Chieh Tsai

Article Type: Case Report | First Published: September 06, 2018

Endometrial cancer is one of the most frequent gynecological cancers in women. According to a recent national survey, endometrial cancer has increased rapidly in the past 30 years in Taiwan and the incidence of endometrioid adenocarcinoma has increased more and more quickly in younger age. Although total hysterectomy is usually recommended to eradicate the malignant lesion, this procedure may not be suitable for a young nulliparous woman, especially when the endometrial cancer is early stage. We...

Volume 5
Issue 9