CASE REPORT | OPEN ACCESS DOI: 10.23937/2474-3658/1510067
Intraleukocytic Yeast Inclusions and Toxic Granulation Neutrophils on Peripheral Blood Smear: An Interesting Synergy between Hematology and Microbiology
Fabio Miglietta1, Claudio Palumbo1, Fernando Parente2, Luciano Velardi3, Rosella Matera4, Luigi Conte4, Michela Dargenio4, Maurizio Quarta5, Milva Maria Nuzzo5, Nicola Di Renzo4 and Giambattista Lobreglio6
1Laboratory of Microbiology, Vito Fazzi Regional Hospital, Lecce, Italy
2Medicine Unit, Vito Fazzi Regional Hospital, Lecce, Italy
3Istituto di Nanotecnologia, CNR-Nanotec, Bari, Italy
4Department of Hematology, Vito Fazzi Regional Hospital, Lecce, Italy
5Infectious Diseases Unit , Vito Fazzi Regional Hospital, Lecce, Italy
6Laboratory of Clinical Pathology, Vito Fazzi Regional Hospital, Lecce, Italy
Abstract
The presence of yeast neutrophil inclusions was observed and discussed several times in other reports; moreover some works demonstrated how Toxic Granulation Neutrophils (TGNs) are especially helpful in predicting acute bacterial infection, while the development of candidaemia-related TGNs was rarely described and in-depth.
We describe two occasional findings of neutrophil inclusions and marked TGNs respectively due to Candida tropicalis and Candida guillermondi on peripheral blood smear.
We proved how the microscopic observation of marked toxic granulations can afford to suspect a systemic microbial infection without the potential to discriminate between bacterial or fungal infections.