Open Access DOI:10.23937/2469-5750/1510128
Extramedullary Acute Undifferentiated Leukemia Presenting in the Skin and Lymph Nodes
Jeremy O'Brien, MD, Zern Chantel, MD and Ikpatt Offiong Francis, MD
Article Type: Case Report | First Published: 2024/05/31
Extramedullary presentation of acute undifferentiated leukemia is uncommon, and it is unclear if this is an initial manifestation of a subsequent systemic disease. We present a 67-year-old Caucasian female with skin lesions and multiple enlarged lymph nodes. Microscopy showed diffuse leukemic infiltrates, positive for dim CD45, CD34, CD117, TdT, CD56 and CD43, but negative for HLADR, MPO, CD4, CD68, CD3, CD4, CD20, CD19, and CD79a. We discuss the differential diagnosis of acute undifferentiated ...
Open Access DOI:10.23937/2469-5750/1510127
Case Series of Kaposi Sarcoma in HIV-negative Men who have Sex with Men: Potential Novel Therapies
N.T. Hilhorst, B. Devocht, E. Verhaeghe, L. Lapeire, L. Vandekerckhove, S. Desmet, MA. De Scheerder and L. Brochez
Article Type: Case Series | First Published: 2024/05/18
Kaposi sarcoma (KS) is a tumor originating from endothelial cells, both vascular and lymphatic, and is associated with human herpesvirus 8 (HHV-8). Four distinct KS subtypes have been defined: Classic, endemic, iatrogenic, and epidemic or acquired immunodeficiency syndrome (AIDS)-related KS. More recently a fifth subtype has been recognized in men having sex with men (MSM) in the absence of human immunodeficiency virus (HIV) infection....
Open Access DOI:10.23937/2469-5750/1510126
Sweet Syndrome Induced by AFINITOR: Case Report
Edgar Bedang Mone Keby da Costa, El khalil El Bakali, Papys Mendes, Youssef Zemmez, Rachid Frikh and Naoufal Hjira
Article Type: Case Report | First Published: 2024/05/13
This is the most common neutrophilic dermatosis and the prototype of superficial dermal acute neutrophilic dermatoses. Its incidence is rare. Sweet's syndrome predilection is for adults aged 30 to 50, but children have also been reported. There is a female predilection [1]. It is distributed worldwide, with no racial predilection. The typical picture is of a sudden-onset rash, accompanied by high fever and neutrophilic leukocytosis [2]. Recombinant granulocyte-colony stimulating factor (G-CSF) h...
Open Access DOI:10.23937/2469-5750/1510125
Rapidly Transforming Mycosis Fungoides
Edgar Bedang Mone Keby da Costa, El Khalil El Bakali, Mohamed Amine Ennaciri, Asmae Benzekri, Youssef Zemmez, Rachid Frikh and Naoufal Hjira
Article Type: Case Report | First Published: 2024/03/03
Mycosis fungoides and its variants account for almost 50% of all cutaneous lymphomas and around 65% of cutaneous T-cell lymphomas. We report the clinical case of a patient with a tumoral nodule, with progressive evolution and rapid transformation. Our patient was undergoing chemotherapy. After mycosis fungoides, CD30+ cutaneous lymphoproliferations are the most frequent pathologies among cutaneous T-cell lymphomas, accounting for 20% of this group....
Open Access DOI:10.23937/2469-5750/1510123
Paraneoplastic Pemphigus Pemphigoid Like
Edgar Bedang Mone Keby da Costa, El khalil El Bakali, Hasna Kerrouche, Mohamed Amine Essaudi, Youssef Zemmez, Rachid Frikh and Naoufal Hjira
Article Type: Case Report | First Published: 2024/02/11
Paraneoplastic pemphigus is a very rare disease. However, it has been described in many countries. It most often affects middle-aged adults, but a few pediatric cases have also been reported. We report the clinical case of a patient being followed for colon cancer who developed erythematous plaques topped by clear and hemorrhagic bullae. Our patient was undergoing treatment with oral corticosteroids and chemotherapy. Paraneoplastic pemphigus was first described in 1990. Since then, numerous case...
