International Journal of

Brain Disorders and TreatmentISSN: 2469-5866


 Open Access DOI:10.23937/2469-5866/1410029

The Role of Prolyl Oligopeptidase in Microtubule-Associated Processes and Cognitive Impairment

Nuria Trallero, Ariadna Anunciacion-Llunell, Roger Prades and Teresa Tarrago

Article Type: Review Article | First Published: June 29, 2019

Prolyl oligopeptidase (POP) is a cytosolic serine protease with prominent expression in the brain. Inhibition of this enzyme leads to cognition-enhancing and neuroprotective effects in animal models with cognitive deficits. However, the biological function of POP remains unknown. Although in the past it was though that its catalytic activity was responsible for its physiological role, lately it has been hypothesized that POP is involved in the inositol pathway and that it interacts with several ...

 Open Access DOI:10.23937/2469-5866/1410028

Pressure Pain Threshold in Depression: Is There a Difference between Unipolar and Bipolar Depressed Patients?

Ozlem Kazan Kizilkurt, Buket Niflioglu, Fusun Mayda Domac and Sermin Kesebir

Article Type: Original Article | First Published: June 06, 2019

complex relationship exists between mood and pain, which is supported by different pain tolerance in clinically depressed patients compared to healthy people. In the present study we aimed to investigate pressure pain threshold (PPT) in unipolar and bipolar depressed patients and assess any differences between these two diagnoses. This study included 40 patients diagnosed with unipolar depression and 89 patients diagnosed with bipolar depression according to DSM-IV criteria, also 40 healthy, age...

 Open Access DOI:10.23937/2469-5866/1410027

Recurrent Agressive Brain Radionecrosis or High-Grade Glioma: How to Treat?

Rascon-Ramirez Fernando Jose Salazar-Asencio OA and Trondin A

Article Type: Case Report | First Published: April 15, 2019

Brain radiation necrosis (BRN) is a side effect of radiotherapy (RT), affecting mainly the white matter and can appear from a few weeks to several years after RT. It's incidence of 3-9% is increasing as survival increases. Histopathology (HP) shows avascular damage, demyelination and direct necrosis. Brain radiation radionecrosis and the tumor progression are difficult to differentiate as both entities are presented with similar radiological and clinical characteristics, such as neurological def...

Volume 5
Issue 1