International Journal of

Blood Research and DisordersISSN: 2469-5696


 Open Access DOI:10.23937/2469-5696/1410019

In vitro Influence of Fibrinogen and Factor XIII on Viscoelastic Characteristics of Clot Formation under Hypothermia and Acidosis

DA Ammon, H Andruszkow, L Sieg, M Wilhelmi, CF Weber, N Rahe-Meyer and AA Hanke

Article Type: Research Article | First Published: November 27, 2015

Hypothermia and acidosis are risk factors for coagulopathy during trauma. We investigated influence of fibrinogen and factor XIII on whole blood coagulation under hypothermia and acidosis in an In vitro model. Fibrinogen, but not FXIII improved coagulation significantly. Furthermore, combined administration of fibrinogen and FXIII did not show differences to administration of fibrinogen alone....

 Open Access DOI:10.23937/2469-5696/1410018

The Management of Mucositis of Pediatric Hematopoietic Stem-Cell Transplantation


Article Type: Perspective | First Published: September 23, 2015

Hematopoietic stem-cell transplantation (HSCT) is used primarily for hematologic and lymphoid cancers but also for many other disorders. Autologous HSCT (in which stem cells are derived from the patient) is mainly used to treat chemosensitive malignancies. Allogeneic HSCT (in which the stem cells are derived from a donor) is often the preferred treatment option, particularly in patients with acute leukaemia. Oral complications are a significant cause of morbidity and potential mortality for chil...

 Open Access DOI:10.23937/2469-5696/1410017

The Evaluation of Serum Protein and Serum Immunofixation Electrophoresis Results in Patients with Monoclonal and Polyclonal Gammopathy: A Single Center Experience

Koksal Deveci, Serdal Korkmaz, Enver Sancakdar, Duygu Acibucu, Filiz Alkan, Hatice Terzi and Mehmet Sencan

Article Type: Research Article | First Published: September 17, 2015

A monoclonal gammopathy is defined as the electrophoretically and antigenically homogeneous protein product of a single clone of B lymphocytes and/or plasma cells that has proliferated beyond the constraints of normal control mechanisms. Monoclonal gammopathies are detected in serum and/or urine from individuals with a wide variety of neoplastic, potentially neoplastic, neurological and infectious conditions....

 Open Access DOI:10.23937/2469-5696/1410016

The Levels of PAI-1, Urokinase uPA, Thrombomodulin and TFPI in Essential Thrombocythemia

Oktay Bilgir, Ferda Bilgir, Mehmet Calan and Giray Bozkaya

Article Type: Research Article | First Published: September 05, 2015

Generally, ET is a myeloproliferative disorder characterized by persistent peripheral thrombocytosis and abnormal megakaryocytic proliferation in the bone marrow. ET is a rare cause of thrombocytosis and may be associated with both venous and arterial thrombosis in 10-75% of cases, depending largely on the study and whether vasomotor symptoms are included in thrombotic manifestations....

 Open Access DOI:10.23937/2469-5696/1410015

The Role of Positron Emission Tomography Imaging in the Risk-Adapted Treatment of Stage I-II Hodgkin's Lymphoma - A Retrospective Analysis

Tom Rider, John Jones, John Brewin, Gillian Horne, Jack Wills, Hannah Barton, Kevin Boyd, Timothy Corbett, Sabina Dizdarevic and Timothy Chevassut

Article Type: Research Article | First Published: July 09, 2015

Early stage Hodgkin's Lymphoma (HL) has excellent outcomes and recent research has focused on minimising treatment-related toxicities. However, the role of 18F-florodeoxyglucose positron emission tomography (FDG PET) imaging in this setting is not fully determined. We retrospectively calculated overall survival (OS) and relapse free survival (RFS) in stage I-II HL when radiotherapy was omitted if post-chemotherapy FDG PET imaging was negative....

Volume 2
Issue 2