International Journal of

Neurology and NeurotherapyISSN: 2378-3001

Archive

 Open Access DOI:10.23937/2378-3001/1410084

Prevention and Treatment of Basic Diseases: A Potential Direction to Intervene Alzheimer's Disease

Wei Jiangping and Xu Shijun

Article Type: Review Article | First Published: May 22, 2019

As the life span of human beings increases, the number of dementia patients such as Alzheimer's disease (AD) is increasing. AD may be one of the major diseases faced by the whole world in the future. It is an unresponsive for single drug according to the current stage of AD pathogenesis and drug research. Combined use of various drugs may be the inevitable trend of AD drug research in the future. Personalized treatment of metabolic diseases, vascular diseases and chronic inflammatory risk diseas...

 Open Access DOI:10.23937/2378-3001/1410083

Involvement of Oxidative Stress, Inflammation, and Glutamate in Ototoxicity, and their Attenuation by Simultaneous Activation of Nrf2 and Elevation of Antioxidant Compounds

Kedar N Prasad

Article Type: Review Article | First Published: May 20, 2019

Diverse groups of ototoxic agents and gene mutation induce hearing disorders. Several studies showed that increased oxidative stress, inflammation, and glutamate are involved in the initiation and progression of hearing disorders. Therefore, reducing these biochemical defects before and after exposure to ototoxic agents may prevent and improve the management of hearing loss. Previous studies with a single agent have yielded variable benefits in hearing disorders. This review briefly presents evi...

 Open Access DOI:10.23937/2378-3001/1410082

Changes in Connectivity between Caudate and Frontal Lobe in Patient with Psychosis Induced for Cannabis - Case Report

Hernandez JF, Marin JH, Naranjo L, Rodriguez and Ramirez SF

Article Type: Case Report | First Published: May 16, 2019

The use of marihuana is becoming more frequent in young people, the association between psychosis and cannabis has been described, especially in young people, we present a clinical case of psychosis associated with cannabis in a young man with normal Brain Magnetic resonance, but abnormalities in tractography mainly in the connectivity between cuadate nucleus and frontal lobe. Several longitudinal population studies strongly association between cannabis and psychosis, particularly in individuals...

 Open Access DOI:10.23937/2378-3001/1410081

Recent Updates on Essential Tremor

Fariha Jamal, MD

Article Type: Review Article | First Published: May 10, 2019

Essential Tremor is the most common movement disorder, but many aspects of this common condition are unclear. There have been multiple updates in the field of Essential Tremor in last few years, that has improved our understanding to some extent. Recently, consensus criteria for classifying tremor disorders was published. Special emphasis was on Essential Tremor, to facilitate better phenotyping and understanding of underlying etiology. Purpose was to identify homogenous population of different ...

 Open Access DOI:10.23937/2378-3001/1410080

Charcot-Marie-Tooth Disease Type 1A and Inflammatory-Demyelinating Lesions in the Central Nervous System

Daniel A Garcia-Estevez, Carmen Cid-Rodriguez and Guillermo Ozaita-Arteche

Article Type: CASE REPORT | First Published: February 23, 2019

Charcot-Marie-Tooth disease (CMT) is a hereditary sensorimotor polyneuropathy which is occasionally associated with demyelinating lesions in the central nervous system, although it remains unclear whether this finding is coincidental or whether the two processes share a common pathogenic mechanism. A male patient with sensorimotor polyneuropathy presented with symptoms consistent with cauda equina syndrome at age 47 in relation to an inflammatory lesion in the conus medullaris. Six years later, ...

 Open Access DOI:10.23937/2378-3001/1410079

Cognitive-Functional Interaction in Patients with Vascular Dementia

Edith Labos, Karina Zabala, Miriam Del Rio, Sofia Trojanowski, Alejandro Renato and Osvaldo Fustinoni

Article Type: Review Article | First Published: February 16, 2019

Vascular Dementia (VD) is the most frequent type of dementia after dementia of the Alzheimer's type (DAT). Its prevalence increases exponentially with age and its risk doubles every 5.3 years. Nevertheless, up to 32% of DAT cases have coexisting cerebrovascular lesions. Cognitive deficits appear very early in patients with cerebrovascular risk. In more than 1000 patients with arterial hypertension recently studied in Argentina, global cognitive impairment was 22.1%. Executive function and semant...

Volume 6
Issue 1