Open Access DOI:10.23937/2378-3001/1410125
Validation of a Suitable Housekeeping Gene in Human Neuroblastoma SHSY-5Y Cell-Line Treated with Steroid Hormones Progesterone and Testosterone
Paula Maria Neufeld, Jonas Frai, Veronika Matschke, Carsten Theiss and Sarah Stahlke
Article Type: Original Article | First Published: 2023/12/30
In this study, we evaluated the stability of three common housekeeping genes, GAPDH, beta-Actin, and 18S-rRNA, in human neuroblastoma SHSY-5Y cells exposed to varying levels of steroid hormones like progesterone (P4) and testosterone. Housekeeping genes serve as reliable internal controls, assumed to maintain consistent expression across diverse tissues and experimental conditions. Since steroid hormones act as ligand-activated transcription factors, directly impacting gene transcription, the id...
Open Access DOI:10.23937/2378-3001/1410124
Feasibility, Cooling Efficacy and Precisionofa Novel System for Temperature Management in Cardiac Arrest, Neurogenic Fever and Covid-19
Johanna Kämpe, Akil Awad, Mohammad Fazel Bakhsheshi, PhD, Svensson L MD, PhD and Per Nordberg, MD, PhD
Article Type: Research Article | First Published: 2023/09/29
In critically ill patients, induced hypothermia or active temperature control to avoid fever are used for neuroprotection. The aim of this study was to determine the feasibility and performance of a novel temperature management system inpatients after cardiac arrest, with neurological fever or due to COVID-19 infection....
Open Access DOI:10.23937/2378-3001/1410114
Incidence of Skeletal Muscle Injury with SARS-CoV-2 Infection in Tertiary Care Hospitals in Qatar
Liaquat Ali, Adnan Khan, Mohammad Alhatou, Osama Elalamy, Beatriz Canibano, Ghulam Adeli, Ahmed Mohammad, Khawaja Haroon, Suhail Hussain, Suha Elmaki, Yahya Imam, Mary Metreenj, Ansaf Ahmed, Jessy Jacob, Lucy Karugu, Neelima John, Kazi Muntaha, Mirza Baig and Ambreen Iqrar
Article Type: Research Article | First Published: November 08, 2021
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is new genus of beta coronavirus that produces diverse neurologic manifestations like myalgia, headache, delirium, anosmia, ageusia, acute ischemic or hemorrhagic stroke, seizures, encephalopathy and rarely Guillain Barr syndrome (GBS), meningoencephalitis and acute disseminated encephalomyelitis (ADEM). 20% of severe COVID-19 intensive care unit admissions are because of some neurological deficits. SARSCoV- 2 virus are very resemblanc...