Influence of BDNF Genotype on the Effect of Neuromodulation on Pain Signalling and Pain Perception in Humans
Magnus Thordstein, Walker S. Jackson, Mats Svantesson and Hedayat Rahin
Article Type: Case Series | First Published: May 10, 2021
Trans-spinal Direct Current Stimulation (tsDCS) can alleviate pain perception in humans through plastic processes. Brain Derived Neurotrophic Factor (BDNF) has been shown to influence a large number of physiological processes including those underpinning neural plasticity. A common polymorphism of BDNF (val66met), reduces the efficiency of plastic processes. We studied the effect of this BDNF polymorphism on the signalling and perception of thermal pain and to what degree these can be influenced...
CGRP Monoclonal Antibodies for Prevention of Migraine: There are Many Adverse Effects
Article Type: Letter to the Editor | First Published: April 18, 2021
This letter is in response to the excellent July, 2020 article “Migraine and CGRP Monoclonal Antibodies: A Review of Cardiovascular Side Effects and Safety Profile” (Boldig and Butala). The package insert (PI) for the CGRP mAbs, as with many of the new drugs, identifies few AEs. The reasons for this include: 1. trial investigators did not use a checklist of AEs (a checklist is almost never utilized during drug trials) 2. As with most drug trials, the studies were powered for efficacy but wou...
Multiple Mononeuropathy in Churg-Strauss Syndrome Presenting as a Subacute Ascending Polineuropathy: A Case Report
Michele Pistacchi, Manuela Gioulis, MD, Sergio Ferrari, MD, Tiziana Cavallaro, MD and Sandro Zambito Marsala, MD
Article Type: Case Report | First Published: March 13, 2021
Multiple mononeuropathy is not unusual in Churg-Strauss Syndrome. Presenting symptoms may be subacute and the differential diagnosis became complicated, particularly when neuropathy is the sole manifestation of disease. We report a clinical case of an adult man hospitalized complaining symptoms of subacute neuropathy successively recognized as multiple mononeuropathy. Histological examination of sural nerve showed the evidence of systemic necrotizing vasculitis with eosinophils infiltration, con...
Peripheral Neuropathies after Bariatric Surgery: A Current Review
Aluísio Stoll, MD, MsC, Dedi Ferreira Alves Neto, Évelin Pereira da Silva, Kéli Daiane Papes, Maria Carolina MianoSelbach, Matheus Fellipe Nascimento de Souza, Letícia Caroline Breis, Laura Fiuza Parolim, MD, Pedro José Tomaselli, MD, MsC, PhD4 and Marcus Vinícius Magno Gonçalves, MD, PhD
Article Type: Non-Systematic Review | First Published: February 06, 2021
Bariatric surgery (BS) is an effective method for sustained weight loss and better quality of life. However, it has its complications. Among those, peripheral neuropathies are important, although underdiagnosed, complications after the surgery. The objective of this article is to describe the most prevalent peripheral neuropathies that may happen after BS, especially focusing on small fiber neuropathies, and the main nutritional deficits involved in these neuropathies. Further studies are needed...