Neuromodulation for Drug-Refractory Epilepsy and Chronic Heart Failure: Targets, Delivery, Composition and Titration
Inder S Anand, MD, FRCP, DPhil (Oxon), Marvin A Konstam, MD, Jeffrey L Ardel, PhD3, Imad Libbus, PhD, Lorenzo A DiCarlo, MD and Douglas L Mann, MD
Article Type: Original Articl e | First Published: September 23, 2019
Vagus nerve stimulation (VNS) is used currently in the management of drug-refractory epilepsy (DRE), and is in development for treating chronic heart failure (HF). HF is accompanied by autonomic nervous system (ANS) dysfunction, consisting of sustained sympathetic hyper-activation and withdrawal of parasympathetic tone, and associated with progressive worsening of cardiovascular (CV) function and increased morbidity and m ortality. We sought to compare how VNS is utilized for DRE and may potenti...
Posterior Circulation Infarcts and Carotid Disease. Is There a Correlation?
Ingram OD, Ali T, Khosla N, Burney K and Kakar P
Article Type: Case Report | First Published: August 14, 2019
We present a case of a 66-year-old man who presented with a history of Right Hemianopia and Right sided facial droop and weakness. CT and MRI brain imaging demonstrated areas of infarction affecting the vascular regions supplied by Left Middle Cerebral Artery and Left Posterior Cerebral Artery circulation. Carotid Duplex Arterial imaging demonstrated moderate Left Internal Carotid Artery Stenosis and CT Angiography demonstrated a dominant Left Posterior Communicating Artery. The origin of the mu...
Positive Airway Pressure Compliance in Patients with Epilepsy and Obstructive Sleep Apnea
Jacob Pellinen MD, Christopher K Cheng MD and Alcibiades J Rodriguez MD
Article Type: BRIEF REPORT | First Published: July 26, 2019
Obstructive sleep apnea (OSA) affects approximately one third of patients with epilepsy. Treatment with Continuous Positive Airway pressure (CPAP) is associated with improved seizure control, but is difficult for patients to tolerate. Patients with epilepsy and co morbid OSA may be at higher risk of recurrent seizures if they are noncompliant with CPAP. This study investigates short-term compliance with CPAP therapy in patients with OSA and epilepsy, as this can predict long-term adherence. Iden...
Unawareness of Olfactory Dysfunction in Older Adults
Amal Loudghi, Majed Alotaibi, Melissa Lessard-Beaudoin, Denis Gris, Kate Busch, Pierrette Gaudreau and Rona K Graham
Article Type: Research Article | First Published: July 15, 2019
Deterioration of olfaction is a common phenomenon observed in the senior population. A number of factors may cause this deficit including infections, aging and neurodegenerative diseases. The aim of this study was to evaluate the reliability of the self-report as a measure of olfactory function in seniors. A total of 93 community-dwelling participants (43 men and 50 women) from the Quebec NuAge cohort on Nutrition and Successful Aging participated in the Olfactory Response and Cognition in Aging...
Prevention and Treatment of Basic Diseases: A Potential Direction to Intervene Alzheimer's Disease
Wei Jiangping and Xu Shijun
Article Type: Review Article | First Published: May 22, 2019
As the life span of human beings increases, the number of dementia patients such as Alzheimer's disease (AD) is increasing. AD may be one of the major diseases faced by the whole world in the future. It is an unresponsive for single drug according to the current stage of AD pathogenesis and drug research. Combined use of various drugs may be the inevitable trend of AD drug research in the future. Personalized treatment of metabolic diseases, vascular diseases and chronic inflammatory risk diseas...
Changes in Connectivity between Caudate and Frontal Lobe in Patient with Psychosis Induced for Cannabis - Case Report
Hernandez JF, Marin JH, Naranjo L, Rodriguez and Ramirez SF
Article Type: Case Report | First Published: May 16, 2019
The use of marihuana is becoming more frequent in young people, the association between psychosis and cannabis has been described, especially in young people, we present a clinical case of psychosis associated with cannabis in a young man with normal Brain Magnetic resonance, but abnormalities in tractography mainly in the connectivity between cuadate nucleus and frontal lobe. Several longitudinal population studies strongly association between cannabis and psychosis, particularly in individuals...
Recent Updates on Essential Tremor
Fariha Jamal, MD
Article Type: Review Article | First Published: May 10, 2019
Essential Tremor is the most common movement disorder, but many aspects of this common condition are unclear. There have been multiple updates in the field of Essential Tremor in last few years, that has improved our understanding to some extent. Recently, consensus criteria for classifying tremor disorders was published. Special emphasis was on Essential Tremor, to facilitate better phenotyping and understanding of underlying etiology. Purpose was to identify homogenous population of different ...
Charcot-Marie-Tooth Disease Type 1A and Inflammatory-Demyelinating Lesions in the Central Nervous System
Daniel A Garcia-Estevez, Carmen Cid-Rodriguez and Guillermo Ozaita-Arteche
Article Type: CASE REPORT | First Published: February 23, 2019
Charcot-Marie-Tooth disease (CMT) is a hereditary sensorimotor polyneuropathy which is occasionally associated with demyelinating lesions in the central nervous system, although it remains unclear whether this finding is coincidental or whether the two processes share a common pathogenic mechanism. A male patient with sensorimotor polyneuropathy presented with symptoms consistent with cauda equina syndrome at age 47 in relation to an inflammatory lesion in the conus medullaris. Six years later, ...
Cognitive-Functional Interaction in Patients with Vascular Dementia
Edith Labos, Karina Zabala, Miriam Del Rio, Sofia Trojanowski, Alejandro Renato and Osvaldo Fustinoni
Article Type: Review Article | First Published: February 16, 2019
Vascular Dementia (VD) is the most frequent type of dementia after dementia of the Alzheimer's type (DAT). Its prevalence increases exponentially with age and its risk doubles every 5.3 years. Nevertheless, up to 32% of DAT cases have coexisting cerebrovascular lesions. Cognitive deficits appear very early in patients with cerebrovascular risk. In more than 1000 patients with arterial hypertension recently studied in Argentina, global cognitive impairment was 22.1%. Executive function and semant...