International Journal of

Neurology and NeurotherapyISSN: 2378-3001

Early Online

 Open Access DOI:10.23937/2378-3001/1410098

Blood Blister-Like Aneurysm of the Intracranial Internal Carotid Artery Associated With Extracranial Dissection of the Artery

Riccardo Russo, Fabrizio Venturi, Mauro Bergui and Gianni Boris Bradac

Article Type: Case Report | First Published: April 23, 2020

Blood blister-like aneurysms (BBAs) have been described as small aneurysmal bulges, more frequently arising from non-branching sites on the supra-clinoid internal carotid artery (ICA). Their etiology is still controversial. In our case the association of the BBA, presenting with a severe subarachnoid bleeding, and extracranial ipsilateral ICA dissection in a patient with fibromuscular dysplasia, could suggest that both lesions were due to the same pathologic process. The aneurysm was treated in ...

 Open Access DOI:10.23937/2378-3001/1410091

Neuromodulation for Drug-Refractory Epilepsy and Chronic Heart Failure: Targets, Delivery, Composition and Titration

Inder S Anand, MD, FRCP, DPhil (Oxon), Marvin A Konstam, MD, Jeffrey L Ardel, PhD3, Imad Libbus, PhD, Lorenzo A DiCarlo, MD and Douglas L Mann, MD

Article Type: Original Articl e | First Published: September 23, 2019

Vagus nerve stimulation (VNS) is used currently in the management of drug-refractory epilepsy (DRE), and is in development for treating chronic heart failure (HF). HF is accompanied by autonomic nervous system (ANS) dysfunction, consisting of sustained sympathetic hyper-activation and withdrawal of parasympathetic tone, and associated with progressive worsening of cardiovascular (CV) function and increased morbidity and m ortality. We sought to compare how VNS is utilized for DRE and may potenti...

 Open Access DOI:10.23937/2378-3001/1410089

The Effects on the Cognitive Function of Healthy Volunteers of a Combination of Acetyl-L-Carnitine, Vinpocetine and Huperzine A Administered Over 28 Days

Keith A Wesnes and Josh Reynolds

Article Type: Original Article | First Published: September 14, 2019

This report on a 4 week, randomized, placebo controlled, parallel group, repeated measures, double-blind study clinical trial of a preparation containing Acetyl-L-Carnitine, Vinpocetine and Huperzine A administered to healthy volunteers has identified that the product significantly improves a well validated global score from six tests of working and episodic memory, with an effect sized improvement comparable to the current medications approved to treat Alzheimers disease. Procera AVH is a prop...

 Open Access DOI:10.23937/2378-3001/1410088

Posterior Circulation Infarcts and Carotid Disease. Is There a Correlation?

Ingram OD, Ali T, Khosla N, Burney K and Kakar P

Article Type: Case Report | First Published: August 14, 2019

We present a case of a 66-year-old man who presented with a history of Right Hemianopia and Right sided facial droop and weakness. CT and MRI brain imaging demonstrated areas of infarction affecting the vascular regions supplied by Left Middle Cerebral Artery and Left Posterior Cerebral Artery circulation. Carotid Duplex Arterial imaging demonstrated moderate Left Internal Carotid Artery Stenosis and CT Angiography demonstrated a dominant Left Posterior Communicating Artery. The origin of the mu...

 Open Access DOI:10.23937/2378-3001/1410087

Positive Airway Pressure Compliance in Patients with Epilepsy and Obstructive Sleep Apnea

Jacob Pellinen MD, Christopher K Cheng MD and Alcibiades J Rodriguez MD

Article Type: BRIEF REPORT | First Published: July 26, 2019

Obstructive sleep apnea (OSA) affects approximately one third of patients with epilepsy. Treatment with Continuous Positive Airway pressure (CPAP) is associated with improved seizure control, but is difficult for patients to tolerate. Patients with epilepsy and co morbid OSA may be at higher risk of recurrent seizures if they are noncompliant with CPAP. This study investigates short-term compliance with CPAP therapy in patients with OSA and epilepsy, as this can predict long-term adherence. Iden...

 Open Access DOI:10.23937/2378-3001/1410086

Unawareness of Olfactory Dysfunction in Older Adults

Amal Loudghi, Majed Alotaibi, Melissa Lessard-Beaudoin, Denis Gris, Kate Busch, Pierrette Gaudreau and Rona K Graham

Article Type: Research Article | First Published: July 15, 2019

Deterioration of olfaction is a common phenomenon observed in the senior population. A number of factors may cause this deficit including infections, aging and neurodegenerative diseases. The aim of this study was to evaluate the reliability of the self-report as a measure of olfactory function in seniors. A total of 93 community-dwelling participants (43 men and 50 women) from the Quebec NuAge cohort on Nutrition and Successful Aging participated in the Olfactory Response and Cognition in Aging...

 Open Access DOI:10.23937/2378-3001/1410085

Views on the Effectiveness of a Google Jam Session for Interdisciplinary Collaborative Brainstorming to Solve Clinical Issues on a Geriatric Dementia Unit

Wally J Bartfay, Brenda Gamble, Andra Duff-Woskosky, Zuhra Mazik and Karen Zavitz

Article Type: Original Article | First Published: June 29, 2019

Dementia is a leading cause of death, disability and hospitalization in Canada and globally. A partnership between Ontario Shores Centre for Mental Health Sciences and Ontario Tech University, both located in the Durham Region in the province of Ontario, Canada was established to create a space of technological innovation in front line dementia care on a Geriatric Dementia Unit (GDU). Our goals are to improve patient quality of life and recovery, enhance the health and well-being of patients wit...

 Open Access DOI:10.23937/2378-3001/1410084

Prevention and Treatment of Basic Diseases: A Potential Direction to Intervene Alzheimer's Disease

Wei Jiangping and Xu Shijun

Article Type: Review Article | First Published: May 22, 2019

As the life span of human beings increases, the number of dementia patients such as Alzheimer's disease (AD) is increasing. AD may be one of the major diseases faced by the whole world in the future. It is an unresponsive for single drug according to the current stage of AD pathogenesis and drug research. Combined use of various drugs may be the inevitable trend of AD drug research in the future. Personalized treatment of metabolic diseases, vascular diseases and chronic inflammatory risk diseas...

 Open Access DOI:10.23937/2378-3001/1410083

Involvement of Oxidative Stress, Inflammation, and Glutamate in Ototoxicity, and their Attenuation by Simultaneous Activation of Nrf2 and Elevation of Antioxidant Compounds

Kedar N Prasad

Article Type: Review Article | First Published: May 20, 2019

Diverse groups of ototoxic agents and gene mutation induce hearing disorders. Several studies showed that increased oxidative stress, inflammation, and glutamate are involved in the initiation and progression of hearing disorders. Therefore, reducing these biochemical defects before and after exposure to ototoxic agents may prevent and improve the management of hearing loss. Previous studies with a single agent have yielded variable benefits in hearing disorders. This review briefly presents evi...

 Open Access DOI:10.23937/2378-3001/1410082

Changes in Connectivity between Caudate and Frontal Lobe in Patient with Psychosis Induced for Cannabis - Case Report

Hernandez JF, Marin JH, Naranjo L, Rodriguez and Ramirez SF

Article Type: Case Report | First Published: May 16, 2019

The use of marihuana is becoming more frequent in young people, the association between psychosis and cannabis has been described, especially in young people, we present a clinical case of psychosis associated with cannabis in a young man with normal Brain Magnetic resonance, but abnormalities in tractography mainly in the connectivity between cuadate nucleus and frontal lobe. Several longitudinal population studies strongly association between cannabis and psychosis, particularly in individuals...

 Open Access DOI:10.23937/2378-3001/1410081

Recent Updates on Essential Tremor

Fariha Jamal, MD

Article Type: Review Article | First Published: May 10, 2019

Essential Tremor is the most common movement disorder, but many aspects of this common condition are unclear. There have been multiple updates in the field of Essential Tremor in last few years, that has improved our understanding to some extent. Recently, consensus criteria for classifying tremor disorders was published. Special emphasis was on Essential Tremor, to facilitate better phenotyping and understanding of underlying etiology. Purpose was to identify homogenous population of different ...

 Open Access DOI:10.23937/2378-3001/1410080

Charcot-Marie-Tooth Disease Type 1A and Inflammatory-Demyelinating Lesions in the Central Nervous System

Daniel A Garcia-Estevez, Carmen Cid-Rodriguez and Guillermo Ozaita-Arteche

Article Type: CASE REPORT | First Published: February 23, 2019

Charcot-Marie-Tooth disease (CMT) is a hereditary sensorimotor polyneuropathy which is occasionally associated with demyelinating lesions in the central nervous system, although it remains unclear whether this finding is coincidental or whether the two processes share a common pathogenic mechanism. A male patient with sensorimotor polyneuropathy presented with symptoms consistent with cauda equina syndrome at age 47 in relation to an inflammatory lesion in the conus medullaris. Six years later, ...

 Open Access DOI:10.23937/2378-3001/1410079

Cognitive-Functional Interaction in Patients with Vascular Dementia

Edith Labos, Karina Zabala, Miriam Del Rio, Sofia Trojanowski, Alejandro Renato and Osvaldo Fustinoni

Article Type: Review Article | First Published: February 16, 2019

Vascular Dementia (VD) is the most frequent type of dementia after dementia of the Alzheimer's type (DAT). Its prevalence increases exponentially with age and its risk doubles every 5.3 years. Nevertheless, up to 32% of DAT cases have coexisting cerebrovascular lesions. Cognitive deficits appear very early in patients with cerebrovascular risk. In more than 1000 patients with arterial hypertension recently studied in Argentina, global cognitive impairment was 22.1%. Executive function and semant...

Volume 6
Issue 1