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International Journal of

Neurology and NeurotherapyISSN: 2378-3001

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 Open Access DOI:10.23937/2378-3001/1410092

Biological Warfare and Snake Venom for Poliomyelitis and ALS: The Little Known Entwined History of Failed Ethics and a Reasonable Therapeutic Hypothesis

Victor M Rivera, MD, FAAN

Article Type: Review Article | First Published: October 14, 2019

This paper describes a complicated history taken place during World War II (WWII) when military intentions for acquiring biological weapon superiority knowledge was obtained in some cases through atrocious investigations in human beings disregarding ethical and moral principles. After the war, Murray Sanders (1910-1988), a young military officer and American scientist became incidentally entwined with the U.S. military concern over the Japanese bacteriological knowledge, unbeknown by the Allies ...

 Open Access DOI:10.23937/2378-3001/1410091

Neuromodulation for Drug-Refractory Epilepsy and Chronic Heart Failure: Targets, Delivery, Composition and Titration

Inder S Anand, MD, FRCP, DPhil (Oxon), Marvin A Konstam, MD, Jeffrey L Ardel, PhD3, Imad Libbus, PhD, Lorenzo A DiCarlo, MD and Douglas L Mann, MD

Article Type: Original Articl e | First Published: September 23, 2019

Vagus nerve stimulation (VNS) is used currently in the management of drug-refractory epilepsy (DRE), and is in development for treating chronic heart failure (HF). HF is accompanied by autonomic nervous system (ANS) dysfunction, consisting of sustained sympathetic hyper-activation and withdrawal of parasympathetic tone, and associated with progressive worsening of cardiovascular (CV) function and increased morbidity and m ortality. We sought to compare how VNS is utilized for DRE and may potenti...

 Open Access DOI:10.23937/2378-3001/1410089

The Effects on the Cognitive Function of Healthy Volunteers of a Combination of Acetyl-L-Carnitine, Vinpocetine and Huperzine A Administered Over 28 Days

Keith A Wesnes and Josh Reynolds

Article Type: Original Article | First Published: September 14, 2019

This report on a 4 week, randomized, placebo controlled, parallel group, repeated measures, double-blind study clinical trial of a preparation containing Acetyl-L-Carnitine, Vinpocetine and Huperzine A administered to healthy volunteers has identified that the product significantly improves a well validated global score from six tests of working and episodic memory, with an effect sized improvement comparable to the current medications approved to treat Alzheimers disease. Procera AVH is a prop...

 Open Access DOI:10.23937/2378-3001/1410088

Posterior Circulation Infarcts and Carotid Disease. Is There a Correlation?

Ingram OD, Ali T, Khosla N, Burney K and Kakar P

Article Type: Case Report | First Published: August 14, 2019

We present a case of a 66-year-old man who presented with a history of Right Hemianopia and Right sided facial droop and weakness. CT and MRI brain imaging demonstrated areas of infarction affecting the vascular regions supplied by Left Middle Cerebral Artery and Left Posterior Cerebral Artery circulation. Carotid Duplex Arterial imaging demonstrated moderate Left Internal Carotid Artery Stenosis and CT Angiography demonstrated a dominant Left Posterior Communicating Artery. The origin of the mu...

 Open Access DOI:10.23937/2378-3001/1410087

Positive Airway Pressure Compliance in Patients with Epilepsy and Obstructive Sleep Apnea

Jacob Pellinen MD, Christopher K Cheng MD and Alcibiades J Rodriguez MD

Article Type: BRIEF REPORT | First Published: July 26, 2019

Obstructive sleep apnea (OSA) affects approximately one third of patients with epilepsy. Treatment with Continuous Positive Airway pressure (CPAP) is associated with improved seizure control, but is difficult for patients to tolerate. Patients with epilepsy and co morbid OSA may be at higher risk of recurrent seizures if they are noncompliant with CPAP. This study investigates short-term compliance with CPAP therapy in patients with OSA and epilepsy, as this can predict long-term adherence. Iden...

 Open Access DOI:10.23937/2378-3001/1410086

Unawareness of Olfactory Dysfunction in Older Adults

Amal Loudghi, Majed Alotaibi, Melissa Lessard-Beaudoin, Denis Gris, Kate Busch, Pierrette Gaudreau and Rona K Graham

Article Type: Research Article | First Published: July 15, 2019

Deterioration of olfaction is a common phenomenon observed in the senior population. A number of factors may cause this deficit including infections, aging and neurodegenerative diseases. The aim of this study was to evaluate the reliability of the self-report as a measure of olfactory function in seniors. A total of 93 community-dwelling participants (43 men and 50 women) from the Quebec NuAge cohort on Nutrition and Successful Aging participated in the Olfactory Response and Cognition in Aging...

Volume 6
Issue 2