Neuromodulation for Drug-Refractory Epilepsy and Chronic Heart Failure: Targets, Delivery, Composition and Titration
Inder S Anand, MD, FRCP, DPhil (Oxon), Marvin A Konstam, MD, Jeffrey L Ardel, PhD3, Imad Libbus, PhD, Lorenzo A DiCarlo, MD and Douglas L Mann, MD
Article Type: Original Articl e | First Published: September 23, 2019
Vagus nerve stimulation (VNS) is used currently in the management of drug-refractory epilepsy (DRE), and is in development for treating chronic heart failure (HF). HF is accompanied by autonomic nervous system (ANS) dysfunction, consisting of sustained sympathetic hyper-activation and withdrawal of parasympathetic tone, and associated with progressive worsening of cardiovascular (CV) function and increased morbidity and m ortality. We sought to compare how VNS is utilized for DRE and may potenti...
Posterior Circulation Infarcts and Carotid Disease. Is There a Correlation?
Ingram OD, Ali T, Khosla N, Burney K and Kakar P
Article Type: Case Report | First Published: August 14, 2019
We present a case of a 66-year-old man who presented with a history of Right Hemianopia and Right sided facial droop and weakness. CT and MRI brain imaging demonstrated areas of infarction affecting the vascular regions supplied by Left Middle Cerebral Artery and Left Posterior Cerebral Artery circulation. Carotid Duplex Arterial imaging demonstrated moderate Left Internal Carotid Artery Stenosis and CT Angiography demonstrated a dominant Left Posterior Communicating Artery. The origin of the mu...
Positive Airway Pressure Compliance in Patients with Epilepsy and Obstructive Sleep Apnea
Jacob Pellinen MD, Christopher K Cheng MD and Alcibiades J Rodriguez MD
Article Type: BRIEF REPORT | First Published: July 26, 2019
Obstructive sleep apnea (OSA) affects approximately one third of patients with epilepsy. Treatment with Continuous Positive Airway pressure (CPAP) is associated with improved seizure control, but is difficult for patients to tolerate. Patients with epilepsy and co morbid OSA may be at higher risk of recurrent seizures if they are noncompliant with CPAP. This study investigates short-term compliance with CPAP therapy in patients with OSA and epilepsy, as this can predict long-term adherence. Iden...
Unawareness of Olfactory Dysfunction in Older Adults
Amal Loudghi, Majed Alotaibi, Melissa Lessard-Beaudoin, Denis Gris, Kate Busch, Pierrette Gaudreau and Rona K Graham
Article Type: Research Article | First Published: July 15, 2019
Deterioration of olfaction is a common phenomenon observed in the senior population. A number of factors may cause this deficit including infections, aging and neurodegenerative diseases. The aim of this study was to evaluate the reliability of the self-report as a measure of olfactory function in seniors. A total of 93 community-dwelling participants (43 men and 50 women) from the Quebec NuAge cohort on Nutrition and Successful Aging participated in the Olfactory Response and Cognition in Aging...