International Journal of

Neurology and NeurotherapyISSN: 2378-3001


 Open Access DOI:10.23937/2378-3001/1410111

Not All Severe Primary Headaches are Migraines - Tension Type Headaches are Far More Common Yet often Labelled as Migraines

Roy G Beran

Article Type: Review Article | First Published: June 07, 2021

This paper reinforces the concept that headaches reside on a continuum with migraine type headache at one end of the spectrum and Tension Type Headache (TTHs) at the other with what used to be referred to as tension/ vascular headaches, along that continuum. This brief overview of headaches is based upon almost half a century of clinical neurological experience by the author, rather than an in depth analysis of definitions and is also dependent upon impressions of patient responses to treatment....

 Open Access DOI:10.23937/2378-3001/1410110

Influence of BDNF Genotype on the Effect of Neuromodulation on Pain Signalling and Pain Perception in Humans

Magnus Thordstein, Walker S. Jackson, Mats Svantesson and Hedayat Rahin

Article Type: Case Series | First Published: May 10, 2021

Trans-spinal Direct Current Stimulation (tsDCS) can alleviate pain perception in humans through plastic processes. Brain Derived Neurotrophic Factor (BDNF) has been shown to influence a large number of physiological processes including those underpinning neural plasticity. A common polymorphism of BDNF (val66met), reduces the efficiency of plastic processes. We studied the effect of this BDNF polymorphism on the signalling and perception of thermal pain and to what degree these can be influenced...

 Open Access DOI:10.23937/2378-3001/1410109

CGRP Monoclonal Antibodies for Prevention of Migraine: There are Many Adverse Effects

Lawrence Robbins

Article Type: Letter to the Editor | First Published: April 18, 2021

This letter is in response to the excellent July, 2020 article “Migraine and CGRP Monoclonal Antibodies: A Review of Cardiovascular Side Effects and Safety Profile” (Boldig and Butala). The package insert (PI) for the CGRP mAbs, as with many of the new drugs, identifies few AEs. The reasons for this include: 1. trial investigators did not use a checklist of AEs (a checklist is almost never utilized during drug trials) 2. As with most drug trials, the studies were powered for efficacy but wou...

 Open Access DOI:10.23937/2378-3001/1410108

Multiple Mononeuropathy in Churg-Strauss Syndrome Presenting as a Subacute Ascending Polineuropathy: A Case Report

Michele Pistacchi, Manuela Gioulis, MD, Sergio Ferrari, MD, Tiziana Cavallaro, MD and Sandro Zambito Marsala, MD

Article Type: Case Report | First Published: March 13, 2021

Multiple mononeuropathy is not unusual in Churg-Strauss Syndrome. Presenting symptoms may be subacute and the differential diagnosis became complicated, particularly when neuropathy is the sole manifestation of disease. We report a clinical case of an adult man hospitalized complaining symptoms of subacute neuropathy successively recognized as multiple mononeuropathy. Histological examination of sural nerve showed the evidence of systemic necrotizing vasculitis with eosinophils infiltration, con...

 Open Access DOI:10.23937/2378-3001/1410107

Peripheral Neuropathies after Bariatric Surgery: A Current Review

Aluísio Stoll, MD, MsC, Dedi Ferreira Alves Neto, Évelin Pereira da Silva, Kéli Daiane Papes, Maria Carolina MianoSelbach, Matheus Fellipe Nascimento de Souza, Letícia Caroline Breis, Laura Fiuza Parolim, MD, Pedro José Tomaselli, MD, MsC, PhD4 and Marcus Vinícius Magno Gonçalves, MD, PhD

Article Type: Non-Systematic Review | First Published: February 06, 2021

Bariatric surgery (BS) is an effective method for sustained weight loss and better quality of life. However, it has its complications. Among those, peripheral neuropathies are important, although underdiagnosed, complications after the surgery. The objective of this article is to describe the most prevalent peripheral neuropathies that may happen after BS, especially focusing on small fiber neuropathies, and the main nutritional deficits involved in these neuropathies. Further studies are needed...

Volume 8
Issue 1