Sporadic studies have investigated the influence of administration time (morning versus evening) on the efficacy and safety of once-daily medications. It is necessary to let clinicians know the developments during the last ten years. Focusing on chronotherapeutic topic, a literature search on randomized controlled trials (RCTs) of oral once-daily cardiovascular agents was conducted using PubMed, Cochrane Library, Scopus and Web of Science from Jan 01, 2008 to Sept 30, 2018....

A 71-year-old man with low back pain for more than a year, cortical erosion and vertebral cyst formation of L4 vertebral body were diagnosed on lumbar MRI. There was no compression fracture or bone marrow edema. The fusiform unruptured aneurysmatic dilatation of abdominal aorta was seen adjacent to the vertebral cyst (Figure 1 and Figure 2). The vertebral cyst was thought to be associated with abdominal aortic aneurysm (AAA). The aortic wall defect or paraaortic hematoma was not established. Aft...

Socio-demographic data, the Charlson Comorbidity Index (CCI), and UEF clinical frailty syndrome classification (non-frail versus pre-frail/frail) were assessed prior to colonoscopy, and acute colonoscopy outcomes were stratified into three severity categories. Logistic regression and ANOVA/ANCOVA were employed. 41% of non-frail had one or more complications, versus 70% of pre-frail/frail group. Those in the pre-frail/frail group had nearly three times the number of acute colonoscopy complication...