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Clinical Medical Image Library

Geographic Atrophy: Ex Vivo Hyperspectral Autofluorescence (AF) Image of an Eye with Geographic Atrophy from 81-Year-Old Male Donor

R. Theodore Smith*, Tal Ben-Ami and Yuehong Tong

New York University, Department of Ophthalmology, Newyork, USA

*Corresponding author: R. Theodore Smith, New York University, Department of Ophthalmology, 550 First Avenue, New York, NY 10016, USA, Tel: 212-263-7300; E-mail:
Clin Med Img Lib, CMIL-1-006, (Volume 1, Issue 1); ISSN: 2474-3682
Published Date: August 25, 2015
Citation: Smith RT, Ben-Ami T, Tong Y (2015) Geographic Atrophy: Ex Vivo Hyperspectral Autofluorescence (AF) Image of an Eye with Geographic Atrophy from 81-Year-Old Male Donor. Clin Med Img Lib 1:006
Copyright: © 2015 Smith RT. This is an open-access content distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

The image is an overlay of 3 images representing the distribution of the 3 most abundant fluorophore signals that were extracted using advanced factorization algorithms. The 3 images were digitally colored red (1), green (2) and blue (3). Localization of the signals into different structures is illustrated by color mixing: Remaining RPE cells (light blue), Granule aggregates shed from dying RPE cells (yellow), Basal Laminar Deposits (orange). This method demonstrates that distinct fluorophore signals identify distinct pathological structures in AMD.

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