A 73-year-old female patient, without any notable pathological history, who presented with an intertrigo of the 4th inter-toe space of the right foot for 6 years and refractory to antifungal treatment, evolving to a protruding lesion. Clinical examination revealed a bulging nodular lesion, filling the entire 4th inter-toe space, 2 × 1.5 cm in size, with a small ulceration and crusts on the surface and the lesion associated with deep cracking of the inter-toe space (Figure 1a, Figure 1b and Figure 1c), without satellite adenopathy. Histological examination showed a tumour proliferation of squamous cells of the epidermis, with hyperchromatic and nucleolated enlarged nuclei, with infiltration of the underlying dermis, in favour of an invasive squamous cell carcinoma. The patient was then referred to plastic surgery for further management.
Figure 1: (A, B & C) Squamous cell carcinoma of the 4th inter-toe space.