Dayer MR, Vahideh-Sadat N, Dayer MS, Alavi SMR (2018) Sex-Related Risk of Myocardial Infarction: Insights from Path Analysis. Int Arch Cardiovasc Dis 2:011 10.23937/iacvd-2017/1710011


© 2018 Dayer MR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

RESEARCH ARTICLE | OPEN ACCESS DOI: 10.23937/iacvd-2017/1710011

Sex-Related Risk of Myocardial Infarction: Insights from Path Analysis

Mohammad Reza Dayer1*, Vahideh-Sadat Nazemi1, Mohammad Saaid Dayer2 and Sayed Mohammad Reza Alavi3

1Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran

2Department of Parasitology and Medical Entomology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

3Department of Statistics, Faculty of Mathematics and Computer Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran


Cardiovascular disease and myocardial infarction comprise the leading causes of more than half of the total death often among elderly people. Psychological stresses, imbalanced diet, sedentary lifestyle, obesity, tobacco, alcohol, and metabolic diseases such as hypothyroidism and diabetes mellitus are the main risk factors for the disease. In order to better understand the underlying risk factor for the disease we performed complete analyses of biochemical factors in sera of obese, non-diabetic and non-hypothyroid male (174) and female patients (213). Among the determinant parameters, TSH, BUN, Creatinine, AST, ALT, FBS, LDL, and TG/HDL ratio, which show correlation and suit structural equation models were selected for path analysis. The averages of these parameters were also compared by one way ANOVA test. In addition, for more detailed comparison, their two-tailed correlations were assessed by Person's test. Our path models indicate that LDL was the central factor mediating causal effects of studied parameters on TG/HDL ratio, the ratio reflecting increased probability for cardiovascular problems. Higher total regression coefficient in female group (twice that of male group) reveals higher susceptibility of female in contrast to male for increased risk of myocardial infarction, the process which we think to be induced primarily by liver abnormality.