Cardiovascular disease and myocardial infarction comprise the leading causes of more than half of the total death often among elderly people. Psychological stresses, imbalanced diet, sedentary lifestyle, obesity, tobacco, alcohol, and metabolic diseases such as hypothyroidism and diabetes mellitus are the main risk factors for the disease. In order to better understand the underlying risk factor for the disease we performed complete analyses of biochemical factors in sera of obese, non-diabetic and non-hypothyroid male (174) and female patients (213). Among the determinant parameters, TSH, BUN, Creatinine, AST, ALT, FBS, LDL, and TG/HDL ratio, which show correlation and suit structural equation models were selected for path analysis. The averages of these parameters were also compared by one way ANOVA test. In addition, for more detailed comparison, their two-tailed correlations were assessed by Person's test. Our path models indicate that LDL was the central factor mediating causal effects of studied parameters on TG/HDL ratio, the ratio reflecting increased probability for cardiovascular problems. Higher total regression coefficient in female group (twice that of male group) reveals higher susceptibility of female in contrast to male for increased risk of myocardial infarction, the process which we think to be induced primarily by liver abnormality.