SAYYİGİT E, PEKKOLAY Z, TUZCU AK (2018) Influence of Insulin Resistance and TSH on the Risk of Malignancy of Thyroid Nodule. Int Arch Endocrinol Clin Res 4:014.


© 2018 SAYYİGİT E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

ORIGINAL ARTICLE | OPEN ACCESS DOI: 10.23937/2572-407X.1510014

Influence of Insulin Resistance and TSH on the Risk of Malignancy of Thyroid Nodule

Erdal SAYYİGİT1, Zafer PEKKOLAY2* and Alpaslan Kemal TUZCU2

1Internal Medicine, Dicle University Medical Faculty, Turkey

2Department of Adult Endocrinology and Metabolism, Dicle University Medical Faculty, Turkey



The incidence of thyroid cancer has increased in recent years. This increase may be due to the change of metabolic parameters in patients. This study was designed to clarify the association of malignancy of thyroid nodules with metabolic parameters.

Materials and methods

This study designed as a cross-sectional study between January 2018 and May 2018. Samples were collected from the patients by thyroid fine needle biopsy and patients who had thyroid surgery. Group 1 patients were pathologically benign patients; Group 2 patients were pathologically malignant. In both groups, preoperative TSH, fasting insulin were measured and HOMA-IR calculated. Statistical analysis was performed.


A total of 84 patients were included in the study. The benign group was 41 (F/M: 33/8) and the malignant group was 43 (F/M: 36/7). TSH levels (1.44 (0.0-9.4) versus 0.41 (0.0-8.9); p < 0.01), fasting insulin levels (13.0 (5.0-40.0) versus 9.4 (3.2-25); p < 0.05) and HOMA-IR levels (2.75 (1.06-13.19) versus 2.24 (0.68-6.3); p < 0.05) were significantly higher in the malignant group.


TSH elevation and insulin resistance may be associated with a risk of malignancyof thyroid nodule.