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International Journal of
Diabetes and Clinical Research ISSN: 2377-3634

Citation

Aljabri KS, Alnasser IM, Bokhari SA, Alshareef MA, Khan PM, et al. (2019) The Prevalence of Hypothyroidism in Patients with Metabolic Syndrome in Saudi Community Based Hospital: A Retrospective Single Centre Study. Int J Diabetes Clin Res 6:103. doi.org/10.23937/2377-3634/1410103

Copyright

© 2019 Aljabri KS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

RESEARCH ARTICLE | OPEN ACCESSDOI: 10.23937/2377-3634/1410103

The Prevalence of Hypothyroidism in Patients with Metabolic Syndrome in Saudi Community Based Hospital: A Retrospective Single Centre Study

Khalid S Aljabri, MD, FRCPC, FACP1, Ibrahim M Alnasser, MD, Facharatz2, Samia A Bokhari, MD, SBEM1, Muneera A Alshareef, MD,SBIM1, Patan M Khan, MD, MRCP1, Abdulla M Mallosho, MD1, Hesham M AbuElsaoud, MD1, Mohammad M Jalal, MD1, Rania F Safwat, MD1, Rehab El Boraie, MD1, Nawaf K Aljabri, MLT3, Waleed O Bawzeer, MD1, Mohammad A Melibari, MD1, Bandari K Aljabri, MS4, Arwa Y Alsuraihi, MS4 and Amjad I Hawsawi, MS4

1Department of Endocrinology, King Fahad Armed Forces Hospital, Jeddah, Kingdom of Saudi Arabia

2Department of Radiology, King Fahad Armed Forces Hospital, Jeddah, Kingdom of Saudi Arabia

3Department of Laboratory, Northern Armed Forces Hospital, Haffr Albatin, Kingdom of Saudi Arabia

4College of Medicine, Umm Al Qura University, Makkah, Kingdom of Saudi Arabia

Abstract

Background and objective

The burden of thyroid diseases in the general population and patients with Metabolic syndrome (MetS) is enormous. To estimate retrospectively the prevalence of hypothyroidism in patients with MetS in Saudi community based hospital.

Design

We analyzed retrospectively 3632 participants whom are between the age 18 to 105 years. All patients were from the population of the Primary health centre at King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia. All data were collected on the basis of a review of electronic medical data. Patients with thyroid stimulating hormone (TSH) above the normal range of TSH for our laboratory reference, history of hypothyroidism and taking thyroid replacement therapy were included. Metabolic risk factors were defined using the 2006 IDF criteria. The total number of cohort were separated on basis of age values into four groups: < 40 years, 40-49 years, 50-59 years and μ 60 years.

Results

3632 subjects were included. There were 830 (22.9%) male and 2802 (77.1%) were female with mean age 44.4 ± 15.6. Hypothyroidism was present in 684 (18.8%). The mean TSH and FT4 values were 3.3 ± 5.4 mIU/l and 15.0 ± 3.0 pmol/l respectively. There were 1556 (42.8%) cases with MetS where female was 1130 (72.6%) and male was 426 (27.4%) with male to female ratio of 1 to 2.6, p < 0.0001, Table 1. Cases with hypothyroidism were significantly more prevalent in patients with MetS, 21.8 vs. 16.6%, p < 0.0001. Regression analysis of odd ratio of risk factors for patients with MetS showed that age and presence of hypothyroidism were associated with higher likely hood of MetS, (OR = 1.095; 95% confidence interval [CI] = 1.088, 1.101), p < 0.0001) and (OR = 1.301; 95% CI = 1.064, 1.589), p = 0.01) respectively. Hypothyroidism was significantly more prevalent in all decades (p < 0.0001) and non-significantly higher across each age groups. Hypothyroidism was non-significantly more prevalent in females below the age 60 years.

Conclusion

The prevalence of hypothyroidism was high in the patients with MetS. The majority of our patients with primary hypothyroidism were old and predominantly females.