Effect of CoQ10 Supplementation on Oxidative Stress and Muscle Bioenergetics in Type II Diabetes: A Pilot Study
Joohee Sanders, PhD, Sinclair Smith, PhD and Carsten Sanders, PhD
Article Type: Original Article | First Published: January 30, 2020
To compare oxidative stress, mitochondrial oxidative phosphorylation capacity, microvascular function, and exercise performance of type II diabetics (T2D) to that of control subjects and to determine whether Co-enzyme Q10 (CoQ10) supplementation has any effects on these measures. Noted reduction in MDA seen in healthy, older individuals suggests a positive antioxidant effect of CoQ10 supplementation. However, when PAD is present, as can be the case of T2D, two weeks of CoQ10 supplementation at 2...
Prevalence of Diabetes Mellitus in Outpatients with Essential Hypertension in a Rural Tertiary Hospital
Ogunmola Olarinde Jeffrey, Ajani Gbadebo Oladimeji and Olabinri Eunice Oluremi
Article Type: Original Article | First Published: December 16, 2019
To determine the prevalence of diabetes mellitus (DM) in patients with essential hypertension attending outpatient medical clinic in a rural community setting of a developing country. This cross-sectional study included patients of a medical outpatient clinic in Federal Teaching Hospital Ido Ekiti, Ekiti State, Nigeria. Study patients were consecutively recruited from Cardiac clinic and baseline investigations obtained from the patients’ files were evaluated including Fasting Blood Glucose (FB...
Type 2 Diabetes Prevalence, Distribution and Risk Factors in St. Kitts and Nevis, West Indies
Jeanita W Richardson, Kelsie D Kelly, Trina K Kumodzi, Nicole Slack Liburd and Hazel Laws, MD
Article Type: Original Article | First Published: November 28, 2019
This study in collaboration with the St. Kitts & Nevis Ministry of Health (MOH) investigated the prevalence of type 2 diabetes and its risk factors, the second leading cause of death in the country. Medical records of patients between the ages of 18 and 75 as of January 1, 2010 treated between January 1, 2010 and December 31, 2015 in the government-funded health centers (HCs) were eligible for inclusion (N = 2737). All HC visits (n = 4169) generated by a representative sample of patients (n = 76...
Effect of Antihypertensive Agents on Biochemical Parameters in Diabetic Patients in Taif - KSA
Niveen M. Daoud, Ola A. Qadi, Dania O. Al-talhi and Hanan Kamal Al-sharabi
Article Type: Clinical Study | First Published: October 21, 2019
Hypertension and diabetes mellitus are chronic medical conditions that frequently coexist. Our objective is to evaluate the effect of Angiotensin converting enzyme inhibitors and Angiotensin II receptor blockers comparatively and in integration with Metformin, dipeptidyl 4 inhibitors and insulin on lipid profile, serum creatinine, liver enzymes and electrolytes in type II diabetic patients. Hypertension and diabetes mellitus are chronic medical conditions that frequently coexist. Obesity, high s...
Insulin Acts as Stimulatory Agent in Diabetes-Related Escherichia Coli Pathogenesis
amelija Madacki-Todorovic, Izet Eminovic, Nadira Ibrisimovic Mehmedinovic and Mirza Ibrisimovic
Article Type: Research Article | First Published: December 05, 2018
In general, diabetic patients are more prone to microbial infections, which is believed to be caused due to high glucose levels in blood which compromise components of the immune system. However, it is little known about role of therapeutic insulin administration on dissemination of infectious diseases in people with diabetes mellitus. The study included the clinically isolated strains of Escherichia coli (E. coli) with biofilm forming capacity as well as referent non-biofilm former E. coli stra...
Insulin Resistance Modification is a Game Changer for Type 2 Diabetes Treatment Strategy
Article Type: Review Article | First Published: October 15, 2018
Insulin resistance, appearing years before diabetes main diagnostic sign, hyperglycemia, stands in the origin of type 2 diabetes (T2DM), generated by complex impairment of a spectrum biochemical processes the most important of which is the failure of phosphatidylinositol 3-kinase enzymatic chain responsible for glucose uptake and endothelial nitric oxide (NO) synthase activation. Therefore in conditions with insulin resistance the impairment of glucose uptake is strongly coupled with NO deficit ...