Effect of Antihypertensive Agents on Biochemical Parameters in Diabetic Patients in Taif - KSA
Niveen M. Daoud, Ola A. Qadi, Dania O. Al-talhi and Hanan Kamal Al-sharabi
Article Type: Clinical Study | First Published: October 21, 2019
Hypertension and diabetes mellitus are chronic medical conditions that frequently coexist. Our objective is to evaluate the effect of Angiotensin converting enzyme inhibitors and Angiotensin II receptor blockers comparatively and in integration with Metformin, dipeptidyl 4 inhibitors and insulin on lipid profile, serum creatinine, liver enzymes and electrolytes in type II diabetic patients. Hypertension and diabetes mellitus are chronic medical conditions that frequently coexist. Obesity, high s...
Insulin Acts as Stimulatory Agent in Diabetes-Related Escherichia Coli Pathogenesis
amelija Madacki-Todorovic, Izet Eminovic, Nadira Ibrisimovic Mehmedinovic and Mirza Ibrisimovic
Article Type: Research Article | First Published: December 05, 2018
In general, diabetic patients are more prone to microbial infections, which is believed to be caused due to high glucose levels in blood which compromise components of the immune system. However, it is little known about role of therapeutic insulin administration on dissemination of infectious diseases in people with diabetes mellitus. The study included the clinically isolated strains of Escherichia coli (E. coli) with biofilm forming capacity as well as referent non-biofilm former E. coli stra...
Insulin Resistance Modification is a Game Changer for Type 2 Diabetes Treatment Strategy
Article Type: Review Article | First Published: October 15, 2018
Insulin resistance, appearing years before diabetes main diagnostic sign, hyperglycemia, stands in the origin of type 2 diabetes (T2DM), generated by complex impairment of a spectrum biochemical processes the most important of which is the failure of phosphatidylinositol 3-kinase enzymatic chain responsible for glucose uptake and endothelial nitric oxide (NO) synthase activation. Therefore in conditions with insulin resistance the impairment of glucose uptake is strongly coupled with NO deficit ...