Cellular Ependymoma is a term losing in the new WHO 2016 criteria, actually are classified as classical or anaplastic or associated to RELA fusion. We presented a rare case report of classical cellular ependymoma in supratentorial location, which presented a neuronal differentiation and desmoplasia in a young man of 29-yr-old, Immunohistochemistry tumor cells expressed Neu-N, Synaptophysin, SNE, α-synuclein, beta tubulin, ubiquitin, neurofilament, D2DR, and GFAP and vimentin. This rare tumor is a very controversial. It was classified as intermediated grade and recently is named as anaplastic or associated to RELA fusion with neuronal differentiation and with dense and diffuse desmoplastic stroma. Genetic expression of RELA gene was required to make a better diagnostic according with the new classification of Central Nervous System classification according with the WHO.