Research Article 

Clinical Risk Factors and Multi-Antimicrobial Resistance Pattern in Community-Acquired Outpatient Urinary Tract Isolates of Escherichia Coli

M Nadeem Ahmed, Debby Vannoy, Ann Frederick and Xuan Bi
Abstract

Urinary tract infections (UTIs) are one of the most commonly treated bacterial infections in ambulatory care clinics and emergency departments (ED). The management of UTIs has been complicated by the emergent resistance to most commonly prescribed antibiotics causing increased patient morbidity, cost of reassessment and retreatment, and rates of hospitalization.

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Research Article 

Assessment of Hand-Cut Injuries among Pathologists and the Efficacy of Cut-Resistant Gloves in Preventing Them

Mohammed Alorini
Abstract

Cutting injuries and needle-stick injuries constitute a potentially fatal danger to pathologists. We evaluated such injuries in four french university anatomic pathology laboratories and analyzed the effect of the using of cut-resistant gloves to prevent these injuries.

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Original Article 

Histologic Evidence of the "Sick Lobe" Carcinogenesis Theory and the Frequency of Intraepithelial Lesions in the Mammary Glands of Female Canines with no Clinical Signs of Neoplasia

Jahnier Andres Caicedo Martinez and Carlos Arturo Iregui Castro
Abstract

Intraepithelial Lesions (IELs) are focal outgrowths of the Mammary Gland (MG), some of which are considered early precursors of tumors. The early detection of IELs has improved the survival rate in women. IELs in female canines have been proposed as a comparative model of IELs in humans.

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short commentary 

A Glance on Nail Involvement by Pemphigus Vulgaris

Vitorino Modesto dos Santos
Abstract

Nail involvement by pemphigus vulgaris is uncommon and has been associated with the severity of disease. Paronychia, onychomadesis, Beau's lines, nail hemorrhages, cross riding, discoloration, hyperkeratosis, pitting, pterygium, onychodystrophy, onycholysis, onychorrhexis, onychoschizia and trachyonychia have been reported. These nail disorders may appear before, concomitantly or after the typical manifestations of pemphigus flare ups.

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Clinical Images 

Endometrioid Adenofibroma: A Case of This Uncommon Benign Tumor of the Ovary Not Associated to Borderline or Endometrioid Carcinoma

Santiago Ortiz and Francisco Tortosa
Abstract

Endometrioid adenofibroma is a benign epithelial and stromal tumor with an endometrioid epithelial component. Less than 20% of the surface epithelial tumors of the ovary have endometrioid differentiation. The majority of endometrioid ovarian neoplasms are carcinomas and the benign form is rarely find.

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Original Research 

Investigation of the Relationship between Malignant Tumors Originated from Peritoneal and Müllerian Epithelium with the Primary and Secondary Müllerian Systems-Immunohistochemical Analysis with Six Markers

Ayse Ciftci, Handan Aker and Hatice Ozer
Abstract

The origin of ovarian epithelial tumors is still indistinct. Müllerian and coelomic hypothesis are controversial. Recently, there is also a small number of reports that tubo-peritoneal junction may play an important role in the development of tubo-ovarian tumors. Therefore, we aimed to investigate the relationship between tumors originating from Mullerian epithelium and peritoneal mesothelium, in other words primary and secondary Müllerian systems.

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Short Commentary 

Radiological Pathology

Shoichi D. Takekawa
Abstract

Pathology and radiology have become pivotal in the clinical practice of daily medicine. Diagnostic radiology and pathology are indeed indispensable wheels of medical practice. Clinicians achieve tentative diagnoses based on laboratory data and medical images in addition to their physical findings and patient medical history. Based on all available findings and on patient characteristics, clinicians finally decide on further therapeutic management strategies, including medical and surgical therapies. Medical images are interpreted and reported by radiologists, yet with current hospital-wide image distribution and viewing systems (PACS) images are immediately and largely available for second reading and interpretation by clinicians.

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Case Report 

Orbital Necrobiotic Xanthogranuloma: A Case Report

Hind M. Alkatan and Abdul Elah A. Al-Abdullah
Abstract

Xanthogranulomatous ocular and periocular lesions in adults have been reported in 3 main forms: adult-onset xanthogranuloma (AXG), necrobiotic xanthogranuloma (NXG), and Erdheim-Chester disease. The three forms differ in regards to laterality, systemic associations, and prognosis. NXG is a rare chronic progressive disease considered to be systemic with mostly asymptomatic internal organ involvement. Ophthalmic manifestations include conjunctival, corneal and scleral involvement. We are presenting a case of NXG with initial presentation as bilateral scleritis and eventual posterior eye and orbital involvement resulting in loss of vision and exenteration. The diagnosis of NXG was not made until 28 years following her initial presentation.

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Review Article 

Squamous Morules (Microcarcinoids) in Gastroesophageal Polyps; a Mimicker of Invasive Carcinoma

Safia N Salaria and Elizabeth Montgomery
Abstract

Colorectal lesions termed squamous morules or microcarcinoids display predominantly squamous and variable endocrine differentiation and are often found in colorectal adenomas with high grade dysplasia thus mimicking invasion. Herein, we describe histopathologic, immunohistochemical classification and clinical correlation of analogous lesions in the esophagus and stomach. We identified five cases (3 men, 2 women) from November 2004-March 2013 of gastric and gastroesophageal polyps with squamous morules. Four of the patients were white. The median age was 70 years (range 59-85 years). Two patients presented with gastrointestinal bleeding, one was undergoing routine screening, and two were followed up for Barrett esophagus (BE) and a history of gastric polyps respectively. Three lesions were gastric, one gastroesophageal (GE), and one patient had both GE and proximal gastric lesions.

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Review Article 

Cancer Stem Cell Microenvironment in Canine Glioblastoma Development: Animal Model for Human Disease

George Stoica
Abstract

Understanding the cancer stem cells (CSCs) role in malignancy is based on a comprehensive understanding of normal stem cells role and plasticity in maintaining the normal homeostasis or regeneration in various organ tissues. The niche microenvironment that sustains and regulates stem cells is tightly regulated by physical factors and hormonal signals. In the central nervous system (CNS) malignancy the CSCs niche is deregulated by intrinsic and extrinsic factors, which disrupt the homeostatic balance from quiescence state to proliferation and differentiation that characterized glioblastoma development.

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Research Article 

Liquid Biopsy: A Future Tool for Post Treatment Surveillance in Head and Neck Cancer?

Joost H Van Ginkel, Manon MH Huibers, Rob Noorlag, Remco de Bree, Robert JJ van Es and Stefan M Willems
Abstract

The prognosis of head and neck squamous cell carcinoma (HNSCC) is largely based on disease stage. Despite improvements in treatment, recurrence rates are still considered high. Currently, disease progression or regression after curative treatment is monitored by clinical evaluation combined with flexible endoscopy and/or imaging.

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Commentary 

Balancing the Harm and Benefit of Disclosure: A Laboratory Physician's Perspective

Chantale Pambrun
Abstract

The four principles of medical ethics that so often appear in the literature encourage physicians to uphold them whenever possible. We are to respect the autonomy of our patients, try to bring them clinical benefit, refrain from harming them, and to be just and fair.

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Case report 

An Uncommon Cause of Skin Discoloration: Purpura Pigmentosa Progressiva

Charles Joseph Haddad, Judella Haddad Lacle and Charles Michael Haddad
Abstract

Purpura Pigmentosa Progressiva is also known as Progressive Pigmentary Dermatitis or Schamberg's Disease. It is a disorder causing skin discoloration on the trunk and extremities, and is a lymphocytic capillaritis of unknown etiology. The disease can occur at any age. It is important to be aware of this disorder since it can mimic other diseases and problems including child and elder abuse, thrombocytopenia purpura.

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