Current Issue

Perspective Article Open Access

C3orf21 and Notch Signaling in Cancer:A Potential Biomarker

Yongjun Zhang, Dehou Deng and Wenlong Bao
Int J Pathol Clin Res Volume 4, Issue 1

Abstract: C3orf21 (chromosome 3 open reading frame 21), also known as xyloside xylosyltransferase 1 (XXYLT1), is located on chromosome 3q29. C3orf21 belongs to the glycosyltransferase 8 family, furthermore, it is a retaining glycosyltransferase. In the extracellular domain of target proteins, XXYLT1 catalyzes addition of the second sylose, and then elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats. XXYLT1 negatively regulates Notch signaling, and aberrations in the Notch signaling pathway were associated with a few types of cancers.

PDF   Full Text   DOI: 10.23937/2469-5807/1510069

Short Review Open Access

Improvement in the Selection of Patients for Anti-PD1 Immunotherapy in Non-Small Cell Lung Cancer (NSCLC) Analyzing Tumor Mutational Burden and Retrotransposon Activity as Possible New Biomarker of Effectiveness

Manuel Cobo-Dols
Int J Pathol Clin Res Volume 4, Issue 1

Abstract: Cancer is one of the leading causes of death. Most patients are diagnosed during the late stages of the disease in several tumors. Unfortunately, current treatment options are limited. Habitually, patients receive first- or second-line chemotherapy and a few patients (5-7%) are candidates for treatment with target agents, that eventually go on to develop resistance to these agents.

PDF   Full Text   DOI: 10.23937/2469-5807/1510068

Case Report Open Access

Cytological Diagnosis of Duodenal Gangliocytic Paraganglioma on Ultrasound-Guided Fine Needle Aspirate: A Case Report with Review of the Literature

Arti Easwar, Dion Middleton and Saverio Ligato
Int J Pathol Clin Res Volume 4, Issue 1

Abstract: Duodenal gangliocytic paraganglioma (DGP) is a rare neoplasm usually found in the second portion of the duodenum and comprised of epithelioid neuroendocrine cells, Schwann cell-like spindle cells, and ganglion cells. We report a case of a 58-year-old male with a duodenal mass discovered incidentally during a staging PET scan for an oropharyngeal carcinoma. An ultrasound-guided fine needle aspirate (FNA) of the lesion revealed fascicles of spindle cells and sparse epithelioid cells with mild cytological atypia.

PDF   Full Text   DOI: 10.23937/2469-5807/1510067

Review Article Open Access

Effects of Residual Oil Fly Ash (ROFA) on the Development of Lung Cancer in Mice

Luis Fernando Antunes Pinheiro, Leonardo Fleury Orlandini, Mariana Scombatti Filipe, Jose Antonio Cordeiro and Patricia Maluf Cury
Int J Pathol Clin Res Volume 4, Issue 1

Abstract: Relationship between environmental pollution and lung cancer has not been fully clarified. There are particles with aerodynamic mass below 2.5 m, capable of directly injuring the lung due to their small size. The majority arise from the burning of fossil combustibles, and are called "residual oil fly ash" (ROFA). They have been demonstrated to damage cells in different ways; however, their relationship with lung cancer etiology has not been clarified.

PDF   Full Text   DOI: 10.23937/2469-5807/1510066

Research Article Open Access

Clinical Risk Factors and Multi-Antimicrobial Resistance Pattern in Community-Acquired Outpatient Urinary Tract Isolates of Escherichia Coli

M Nadeem Ahmed, Debby Vannoy, Ann Frederick and Xuan Bi
Int J Pathol Clin Res Volume 4, Issue 1

Abstract: Urinary tract infections (UTIs) are one of the most commonly treated bacterial infections in ambulatory care clinics and emergency departments (ED). The management of UTIs has been complicated by the emergent resistance to most commonly prescribed antibiotics causing increased patient morbidity, cost of reassessment and retreatment, and rates of hospitalization.

PDF   Full Text   DOI: 10.23937/2469-5807/1510065

Research Article Open Access

Assessment of Hand-Cut Injuries among Pathologists and the Efficacy of Cut-Resistant Gloves in Preventing Them

Mohammed Alorini
Int J Pathol Clin Res Volume 4, Issue 1

Abstract: Cutting injuries and needle-stick injuries constitute a potentially fatal danger to pathologists. We evaluated such injuries in four french university anatomic pathology laboratories and analyzed the effect of the using of cut-resistant gloves to prevent these injuries.

PDF   Full Text   DOI: 10.23937/2469-5807/1510064

Volume 4
Issue 1