Research Statistical Method Seemingly Non-Transferrable to Clinical Pathology Practice: A Case for D-Dimer Quantitative Testing
Ezekiel Uba Nwose, Phillip Taderera Bwititi and Ross Stuart Richards
Article Type: Brief Report | First Published: December 13, 2018
Plasma D-dimer data are often not normally distributed. In the research setting, such data is non-parametric and statistical analysis is often based on log-transformed data. In the clinical pathology, results are not transformed, but interpreted as it is. Plasma D-dimer data are often not normally distributed. In the research setting, such data is non-parametric and statistical analysis is often based on log-transformed data. In the clinical pathology, results are not transformed, but interprete...
Influence of Anticoagulants on Determination of H2O2 Levels in Blood: Comparison of Citrate and EDTA
Nwose EU, Bwititi PT and Chalada MJ
Article Type: Research Article | First Published: December 12, 2018
H2O2 is supposed to be part of the laboratory test panel for assessment of oxidative stress. This molecule contributes to oxidative stress by reacting with Fe2+ ions to produce hydroxyl radicals. Anticoagulants, including citrate and EDTA chelate Fe2+, possibly have implications in oxidative stress studies especially when H2O2 is measured. This brief commentary is on the measurability of H2O2 in citrated and EDTA blood samples....
Biological Role of Transcription Factor Twist1 in Diffuse Large B-Cell Lymphoma and Follicular Lymphoma
Vanessa Szablewski, Natacha Merindol, Sophie Ballazin, Valerie Costes-Martineau and Nathalie Bonnefoy
Article Type: Original Research | First Published: December 08, 2018
Twist1 expression was investigated by both real-time quantitative polymerase chain reaction (RT-QPCR) and immunohistochemistry in 8 samples from reactive lymphoid tissues, 38 samples from DLBCL and 25 samples from FL patients. Results were correlated with clinicopathologic features. Both RT-QPCR and immunohistochemistry demonstrated increased Twist1 in DLBCL and FL in comparison to benign lymph nodes, where only stromal cells expressed Twist1. Twist1 was higher in FL. In DLBCL there was a tenden...
Is p53 Overexpression a Predictor of Worse Outcomes in Endometrioid Endometrial Carcinomas?
Raid Jastania and Tahani Nageeti
Article Type: Review Article | First Published: November 22, 2018
Endometrial cancer (EC) is the most common neoplasm of the female genital tract. Although immunohistochemical methods have been used for detecting several biomarkers for several cancer types, this method is still underutilized in EC. We conducted this review to identify the currently available published evidence to support the utilization of immunohistochemical for p53 protein overexpression as prognostic and predictive biomarkers of disease outcomes in endometrioid endometrial carcinoma....
Intratubular Large Cell Hyalinizing Sertoli Cell Tumor of the Testes in Peutz-Jeghers Syndrome: A Case Report
Esra Polat, Yasemin Ozluk and Cagla Karaoglan
Article Type: Research Article | First Published: November 12, 2018
Polyposis disorders of the bowel in the pediatric population are associated with elevated risks of various cancers. The most common sites of the malignancies were the gastrointestinal system, breast, gynecological organs, testis, pancreas and lung. Testicular lesions are often overlooked as PJS predominantly appear in females. A 9-year-old boy was presented to gastroenterology policlinic due to pallor. He had a history of diagnostic laparotomy when he was nine dues to acute abdomen where intussu...
Liver Fibrosis Quantification by Digital Whole Slide Imaging and Two Photon Microscopy with Second Harmonic Generation
Jolanta Jedrzkiewicz, Mary P Bronner, Mohamed E Salama, Jessica Kohan, Leslie R Rowe, Dean Tai, Elisabeth Malmberg and Erinn Downs-Kelly
Article Type: Original Article | First Published: October 12, 2018
The progression of fibrosis in liver disease is the single most important pathologic process guiding patient prognosis and treatment decisions. Unfortunately, its histologic assessment is subjective, descriptive and non-quantitative. A more objective and uniform method is needed to assess fibrosis in order to optimize patient care. To that end, we employed two new quantitative imaging technologies to evaluate fibrosis....
Gastric Composite Tumor: A Mixed Adenocarcinoma and Neuroendocrine Tumor with Goblet Cell Carcinoid Component
Archana Lakshmanan, Ann Kurian and Annapurneswari Subramanyan
Article Type: Case Report | First Published: October 12, 2018
Goblet cell carcinoids are distinct neoplasms with combined histologic features of carcinoid and adenocarcinoma with the intermediate prognosis. They are initially thought to arise only from the appendix, however, in the recent past, a few cases have been described in extra appendiceal locations. Mixed adenoneuroendocrine tumors of the stomach are uncommon and that including Goblet cell carcinoid component is exceedingly rare. We report a case of composite tumor involving the stomach with four d...
Hodgkin Lymphoma Involving the Oesophagus: A Case Report
Ban Sulaiman, Iram Naaz and Anne Crotty
Article Type: Case Report | First Published: September 29, 2018
Lymphomas of the gastrointestinal tract are very rare. Primary and secondary oesophageal lymphoma account for less than 1% of all gastrointestinal lymphomas. Secondary oesophageal involvement is by contiguous spread from the stomach or surrounding lymph nodes. Patients with oesophageal lymphoma have varying presentations and complications which include perforation with a tracheo-oesophageal fistula, mass and haemorrhage....
Chromatin Lipid Microdomains
Carmela Conte, Michela Codini and Elisabetta Albi
Article Type: Commentary | First Published: September 19, 2018
In nuclear membrane, the precise relation among these lipids is responsible for maintenance of normal fluidity in no stimulated cells. During rat liver regeneration, in which the cells are stimulated to proliferate, lipid composition and consequently fluidity of nuclear membranes modify, favoring an increase of mRNA transport that...
The Study of Ductal Carcinoma In Situ (DCIS) with Microinvasion Using Myoepithelial Markers
Sana Firdous, Anjaneyulu, Daphne Fonseca, Sudha Murthy, Sundaram Challa and CK Naidu
Article Type: Research Article | First Published: September 14, 2018
DCIS is a premalignant condition characterized by proliferation of neoplastic cells within the ducts with intact myoepithelial cell layer and when there is a breach in myoepithelial cell layer it indicates invasion and in both these condition treatment protocols and prognosis is different. Myoepithelial markers can be used to identify breach and hence invasion....
Ambiguity in Diagnosis of Extra-Pulmonary Breast Tuberculosis as Breast Abscess/Duct Ectasia
Hemlata Panwar, T Santosh, Bharti Kumari, Vandita Singh and RK Ramchandani
Article Type: Case Report | First Published: September 03, 2018
Tubercular mastitis is a great masquerader and is an extremely rare entity as extra-pulmonary tuberculosis even in endemic countries like India and incidence accounts for 4% of breast lesions. We report a case of primary TB of breast in a elderly female presenting as diffuse upper left breast lump with indurated and ulcerated overlying skin along with retraction of nipple. Clinically suspicion was of abscess and duct ectasia. Fine needle aspiration cytology (FNAC) of breast lump with touch impri...
Malignant Melanoma Arising of Gland Pigmentary Disorders
Vitorino Modesto dos Santos and Lister Arruda Modesto dos Santos
Article Type: Letter To Editor | First Published: September 03, 2018
Malignant melanoma represents up to 5% of cutaneous cancers, but up to 75% of the cases have fatal outcomes. The early diagnosis and prompt treatment can reduce the impressive mortality rate of this ominous malignancy. Both amelanotic and melanotic melanoma may be associated with delayed clinical suspicion and late diagnosis, harmful occurrence that may be related to lack of awareness of health care workers or unusual site of the tumors. The manuscripts herein commented described exceeding rare ...
Bilateral Vulvar Ectopic Breast Tissue in a 38-Year-Old Woman Who is Breastfeeding: Case Report and Review of the Literature
Maria Sol Peremateu, Maria Lucrecia Absi, Maria Celeste Sluga, Alejandra Wernicke and Claudia Marchitelli
Article Type: Case Report | First Published: August 29, 2018
Though long considered to be ectopic breast tissue representing the caudal remnants of the milk ridges, anogenital mammary-like glands are nowadays believed to represent a normal constituent of the anogenital area. Lesions involving these glands are histologically similar to their mammary counterparts and can develop the same benign and malignant tumors as the normally located breast. Because of their infrequent presentation, they represent a challenge for physicians....
A 68-Year-Old Man with Apathetic Hyperthyroidism and Lung Cancer
Vitorino Modesto dos Santos and Lister Arruda Modesto dos Santos
Article Type: Case Report | First Published: August 23, 2018
The case study of a non-small cell lung carcinoma confirmed by complete necropsy study is reported in an old man with apathetic hyperthyroidism, atrial fibrillation and heart failure. The authors emphasize diagnostic challenges related to effects of hyperthyroidism on nutritional status versus under nutrition caused by unsuspected development of a coexistent malignancy....