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International Journal of

Pathology and Clinical ResearchISSN: 2469-5807

Early Online

 Open Access DOI:10.23937/2469-5807/1510138

Study of Spectrum of Lesions in Bone Marrow Aspiration and Trephine Biopsy from a Tertiary Care Centre in South India

Gaurvi Piplani and Teerthanath S

Article Type: Original Article | First Published: October 28, 2022

Bone marrow examination is an important diagnostic tool widely used in various haematological and non-haematological disorders. Bone marrow evaluation may either confirm clinically suspected disease or may provide the previously unsuspected diagnosis. To study the spectrum of lesions, comparison and evaluation of diagnostic efficacy of the bone marrow aspiration and bone marrow biopsy findings in various haematological and non-haematological disorders....

 Open Access DOI:10.23937/2469-5807/1510137

Do Messenger RNA Vaccines Induce Pathological Syncytia?

Adonis Sfera, MD, Karina G Thomas, DAN O Sfera, Jonathan J Anton, Christina V Andronescu, Nyla Jafri, Sarvin Sasannia and Zisis Kozlakidis

Article Type: Review Article | First Published: October 20, 2022

The Pfizer and Moderna COVID-19 vaccines are composed of lipid nanoparticles (LNP) containing a modified messenger RNA (mRNA) that encodes for the Spike S protein. The LNP transfection likely involves particle engulfment by the host immune cells due to their resemblance to apoptotic bodies, vesicles with externalized phosphatidylserine (ePS). As the LNPs are decorated with PS-like ionizable phospholipids, including 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), they encourage human phagocyte...

 Open Access DOI:10.23937/2469-5807/1510136

Congenital Cystic Pulmonary Airway Malformation with Intralobar Sequestration in 15 Weeks Old Fetus- Peculiarity of Early Developmental Stage

Daria Kozlova, Sharon Perlman, Roee Birnbaum, Ori Mayer and Yinon Gilboa

Article Type: Case Report | First Published: August 20, 2022

Congenital pulmonary airway malformations (CPAMs) consist of a spectrum of cystic or non-cystic lung malformations often associated with bronchial atresia during in utero development. Several classifications for these lesions have been proposed using radiologic or pathologic criteria based on cyst size and histology, with the Stocker classification being perhaps the most commonly used in the pathology literature....

 Open Access DOI:10.23937/2469-5807/1510135

PRAME Expression in Mimickers of Melanoma in Situ: Paget’s Disease, Extramammary Paget’s Disease, and Pagetoid Squamous Cell Carcinoma in Situ

Cary Chisholm, MD, Michael Hatch, MD, Sage Post and Sage Chain

Article Type: Research Article | First Published: August 19, 2022

Antibodies towards Preferentially Expressed Antigen in Melanoma (PRAME) have shown promise to discriminate between melanoma in situ (MIS) and benign melanocytic lesions. Paget’s disease, extramammary Paget’s disease, and squamous cell carcinoma in situ may mimic the morphologic features of MIS, and PRAME expression in these lesions has not yet been described....

 Open Access DOI:10.23937/2469-5807/1510134

Monoclonal Light Chains in Multiple Myeloma: The Sinister Immunoglobulin

Gurmukh Singh, MD, PhD, MBA, Hongyan Xu, PhD and Roni J Bollag, MD, PhD

Article Type: Clinical Research | First Published: August 04, 2022

Multiple myelomas are the commonest hematological malignancy in adults, next to the heterogeneous group non- Hodgkin lymphomas, and account for about 10% of such tumors. About 21% of the multiple myelomas are associated with higher levels of free monoclonal light chains. This subgroup of patients exhibits high incidence of renal disease manifested by significantly lower estimated glomerular filtration rate, higher incidence of dialysis and significantly shorter survival....

 Open Access DOI:10.23937/2469-5807/1510133

Assessment of Serum Copper and Zinc Status in Patients Receiving Highly Active Antiretroviral Therapy in A Tertiary Health Institution in Southwest Nigeria

Taiwo Oloyede, Elizabeth Oke, Taiwo Alatishe, Samson Ojedokun, Adeolu Akinboro, Kunle Oreagba and Abdulkareem Afolabi Salawu

Article Type: Original Research | First Published: July 30, 2022

The poor prognosis and mortality in HIV infection has been associated with deficiency of micronutrients such as zinc and copper. This study aimed to investigate the level and deficiency of some trace elements in HIV-seropositive subjects receiving HAART treatment....

 Open Access DOI:10.23937/2469-5807/1510132

Basal-Like Atypical Ductal Hyperplasia and Basal-Like Ductal Carcinoma In Situ: Evidence for Precursor of Basal-Like Breast Cancer

Jing Wang and Lavinia P. Middleton

Article Type: Original Article | First Published: July 28, 2022

Basal-like breast cancer (BLBC) is identified by gene expression profiling studies and is associated with worse overall survival. The identification of possible precursors of BLBC is important to gain insight into tumorigenesis and therapeutic targets. This retrospective study evaluated the characteristics of possible precursors of BLBC, including basal-like atypical ductal hyperplasia (bADH) and basal-like ductal carcinoma in situ (bDCIS); basal cytokeratin (CK) expression in bADH and bDCIS; an...

 Open Access DOI:10.23937/2469-5807/1510131

Cellular Angiofibroma: A Rare Tumor Behind the Ear

Canan Firat, Ayca Ersen Danyeli, Yuksel Olgun and Sulen Sarioglu

Article Type: Case Report | First Published: July 28, 2022

Cellular angiofibroma (CA) is an uncommon benign soft tissue tumor and typically arises in genitourinary region. There are only three reported cases at the head and neck region to the best of our knowledge; two different sites at eyelid and buccal mucosa. A 67-year-old man presented to the otorhinolaryngology unit with a painless nodule behind the left ear. Ultrasonography revealed a subcutaneous non-vascular, hyperechoic, homogenous, solid, 15×15 mm mass....

 Open Access DOI:10.23937/2469-5807/1510130

Hidradenocarcinoma Treated with Mohs Surgery

Jenna Lee, MS, Carolina Puyana, MD, MSPH, Wenhua Liu, MD, Vassilios Dimitropoulous, MD and Roger Haber, MD

Article Type: Case Report | First Published: August 18, 2022

Hidradenocarcinoma (HAC) is an exceedingly rare and aggressive malignant tumor of the adnexal eccrine and apocrine sweat gland. Due to its low incidence rate, nonspecific clinical presentation, and similar histopathological features to benign hidradenoma (HA), HAC is often misdiagnosed as its benign counterpart. Histologically, even the absence of cellular atypia does not rule out malignancy....

 Open Access DOI:10.23937/2469-5807/1510129

Primary Pulmonary Colloid Adenocarcinoma: A Case Report with Literature Review

Emna Braham, Farah Sassi, Mehdi Abdennadher, Mona Mlika and Faouzi El Mezni

Article Type: Case Report | First Published: July 16, 2022

Pulmonary colloid adenocarcinomas are uncommon tumors individualized as a distinct entity in the histological classification of World Health Organisation of lung tumors characterized by extensive pool of extracellular mucin distending and destroying alveolar walls. We herein report a case of a 63 year-old active man smoker who presented with a worsening dyspnea. A chest computed tomography scan showed a highly suspected irregular nodule of 23 mm in the left-upper lobe....

 Open Access DOI:10.23937/2469-5807/1510128

IMP3 Expression in Thyroid Cancers and its Relationship with Prognostic Parameters

Gamze Ozcan, Mihriban Gurbuze, MD and Serap Pamak Bulut, MD

Article Type: Original Article | First Published: May 26, 2022

The study included 60 cases diagnosed with thyroid carcinoma in the pathology department of Haseki Hospital. As the control group, two follicular adenomas, three Hurthle cell adenomas, and five nodular hyperplasia cases were included in the study....

 Open Access DOI:10.23937/2469-5807/1510127

Evaluation of Pathological Parameters of Two-Year Bladder Urothelial Carcinomas in Association with Literature

Mürüvvet Akçay Çelik, MD and Yeliz Kaşko Arıcı

Article Type: Research Article | First Published: April 21, 2022

In this study, it was aimed to evaluate the pathological parameters in cases with bladder urothelial carcinoma diagnosed in our department, and to investigate the relationship between the cases in the literature and age, gender correlation. In our Faculty of Medicine, Department of Pathology, 68 bladder biopsy cases diagnosed with urothelial carcinoma between 2018-2019 were included in the study. The pathology reports of the cases were evaluated retrospectively. According to the one-way chi-squa...

 Open Access DOI:10.23937/2469-5807/1510126

Lung Abscess as a Complication of SARS-CoV-2 Infection Associated with Mucormycosis in a Romanian Patient

Maria Sajin, Florina Almarii, MD, Iona Eliza Gaianu and George Simion

Article Type: Case Report | First Published: April 08, 2022

Formation of lung abscesses after Covid-19 is a newly emerging complication and superimposed mucormycosis infection is quite rare. We report the case of 62-years-old male who developed a lung abscess after being infected with SARS-COV-2. Because of the unresponsiveness to pharmacological treatment and ongoing lung damage, surgical approach was required. This is the case of a 62-years-old patient who was transferred to our hospital for the management of a non-resolving lung abscess. He was treate...

 Open Access DOI:10.23937/2469-5807/1510125

Criteria for Presumptive Diagnosis of IgD Multiple Myeloma

Gurmukh Singh, MD, PhD, MBA

Article Type: Research Article | First Published: March 25, 2022

IgD myelomas constitute about 1% of myelomas, have worse prognosis, have higher association with lambda light chains, and are associated with excess free involved light chains. Standard immunofixation protocols stain only for IgG, IgM and IgA heavy chains. Proper attribution of a monoclonal gammopathy as having a delta heavy chain requires additional testing that is not available in most clinical laboratories. Retrospective review of protein electrophoresis and other laboratory results showed ch...

 Open Access DOI:10.23937/2469-5807/1510124

Diffuse Intestinal Ganglioneuromatosis: A Case Report with Review of Literature

Hussein Kaouk, Josiane Mansour, Layla Abou Khana, Rosy Feghaly and Georges Aftimos

Article Type: Case Report | First Published: February 19, 2022

Intestinal ganglioneuromatosis is a rare neoplastic disease characterized by an important proliferation of Schwann cells, nerve fibers and ganglion cells in the intestinal wall. We present a case of 36-years-old male who presented with abdominal pain, constipation and vomiting of several days duration. On admission, intestinal occlusion was suspected and urgent laparotomy was done during which numerous nodules were found in the small bowel. Eventually, a segment of the bowel was resected and his...

 Open Access DOI:10.23937/2469-5807/1510123

High Expression of RAGE and HMGB1 in Lung Tissue of Decedents with COVID-19 and Diabetes

Yared Tekabe, Anjali Saqi, Geping Zhang, Monica Goldklang and Lynne L Johnson

Article Type: Original Research | First Published: February 17, 2022

Serum biomarker studies on patients with severe COVID-19 lung disease indicate that increased ligands for Receptor for Advanced Glycation End-products (RAGE) and diabetes are risk factors for severe acute respiratory distress syndrome (ARDS). To investigate in situ RAGE expression in coronavirus disease-19 (COVID-19) ARDS, we obtained lung tissue from autopsies performed on COVID-19 decedents with clinical ARDS and corresponding pathology showing diffuse alveolar damage (DAD) both with and witho...

Volume 8
Issue 1