Mathematical Hegselmann-Krause (HK) Model Predicts Chemotherapeutic Resistance to Cisplatin in Human Cervical Cancer Cell Lines
John Zihou Chen, Rong Wu, Henry Simpkins, Zhendong Sun and Jianli Chen
Article Type: Original Research Article | First Published: September 25, 2019
Solid tumors usually have a complex cellular components and intercellular interactions in a complex tumor microenvironment. We used a mathematical HK model to predict the change of drug resistance to cisplatin in a mixed sensitive and resistant human cervical cancer cell population and then employed a cytosensitivity assay to evaluate if biological findings could confirm this change predicted by HK model. We used the HK model to predict the resistance to cisplatin in the mixed cell population. T...
A Mathematical Method to Easily and Accurately Measure the Tumor Volume of Prostate Cancer on Pathological Slides
John Zihou Chen, Monika Wrzolek, Lynne Opitz and Jianli Chen
Article Type: Original Research Article | First Published: September 21, 2019
For decades, it has been a big challenge to directly and accurately measure an irregularly shaped area for a tumor volume evaluation of prostate cancer. All current methods are not ideal for different reasons. An objective, practical, accurate, and reliable method for measuring of prostate cancer volume is needed, in particular in modern precision medicine setting, pursuing accuracy and quality of health care. In this study, we applied a mathematical method - the Gauss area calculation formula t...
Comparative Immunohistochemical Staining for Chromogranin A and Synaptophysin in Intestinal Carcinoids
Article Type: Research Article | First Published: September 16, 2019
Duodenal and ileal carcinoids were strongly positive for CgA, with or without invasion through intestinal wall. Small appendiceal carcinoids were weakly immunostained for CgA and SPY. Colorectal carcinoids were low-grade tumors especially those of small polypoid tumors (< 1.0 cm) with CgA-negative staining while larger tumors (> 2.0 cm) infiltrating through wall were more aggressive with often CgA positive staining. CgA positive carcinoids of duodenum, small intestine and colorectum of larger th...
Acrometastasis to Foot Revealing an Occult Lung Adenocarcinoma: Case Report and Literature Review
Ignez Candeloro and Bruno de Carvalho Dornelas
Article Type: Case Report and Literature Review | First Published: September 11, 2019
Metastases to the foot bones are uncommon and they mimic inflammatory conditions. Acrometastases may be the first manifestation of an unknown primary malignant disease. We report a case in which the first sign of lung adenocarcinoma was a pathological fracture due to metastasis to a proximal toe phalanx. A 68-year-old man was evaluated for pain in his fifth toe of the left foot after a trauma. Biopsy and immunohistochemistry reactions confirmed the metastatic lesion. Unfavorable clinical course ...
Extra-Nodal Non-Cutaneous Peripheral T cell Lymphoma: Common Peripheral Blood Findings and Clinical Follow Up
Hongwei Ma, Catherine Xie, Mohamed Masoud, Robin Williams and Ming Xie
Article Type: Research Article | First Published: September 07, 2019
Peripheral T cell lymphoma (TCL) is relatively uncommon and may involve lymph node, skin and extra-nodal non-cutaneous organs. Nodal TCL often presents as systemic disease with unfavorable outcomes. Extra-nodal non-cutaneous TCL, however, may remain as localized disease and be treated differently with favorable prognosis. This study revealed the common peripheral blood findings and clinical follow ups in patients with extra-nodal non-cutaneous mature TCL. There were 9 patients, 5 males and 4 fem...
Retroperitoneal Malignant Solitary Fibrous Tumor: A Case Report and Review of the Literature
Gumusay Ozge, Koseoglu Resit Dogan, Arici Akgul and Akin Ali
Article Type: Case Report | First Published: August 29, 2019
Solitary fibrous tumor is a rare soft-tissue neoplasm that is capable of metastasis of fibroblastic/ myofibroblastic cell origin. Although most of the cases are pleural in origin, extrapleural locations are reported with increasing frequency. Extrapleural cases are mostly seen in retroperitoneal location. Malignant forms are much rarer. The hemangiopericytomatous pattern is seen in many soft tissue tumors. Many cases with extrapleural/ extrathoracal locations that were previously diagnosed as he...
Adenomatoid Tumor in the Fallopian Tube - A Rare Case
Geetika Goyal, DNB, MD, Arati Inamdar, MD and Abraham Loo, MD
Article Type: Case Report | First Published: July 27, 2019
Adenomatoid tumors are benign tumors of mesothelial origin seen in female genitourinary tract, most commonly involving the uterus and rarely fallopian tubes. We herein report a case of 46-year-old female who presented with abnormal vaginal bleeding with complex cyst in left adnexa and multiple leiomyomata upon pelvic imaging. Hysterectomy and bilateral salpingectomy were done. A circumscribed red-tan nodule, measuring 3.0 cm in maximum dimensions was identified on the left fallopian tube with a ...
Influence of Image Manipulation Restricted to Global Alterations on Diagnosis by an Oral Cytologist
Aman Chowdhry, Keya Sircar and Deepika Bablani Popli
Article Type: Original Research | First Published: July 24, 2019
Cytology has always proudly been in forefront to absorb new technologic advances for practical use. The extensive and passionate implementation of digital imaging in telecytology, automated screening, education, training and certification, research, and publications is an appropriate example. Digitalization cytology records make its manipulation very simple. Several such manipulations, however, correspond to inappropriate changes and can affect final diagnosis of digital slides....
Craniopharyngioma Brain Invasion Forms
Martha Lilia Tena-Suck, Ma Elena Hernandez-CaMartha Lilia Tena-Suck, Ma Elena Hernandez-Campos, Alma Ortiz Plataa, Carlos Sanchez-Garibay, Citlaltepetl Salinas Lara and Carlos Penafielmpos, Alma Ortiz Plataa, Carlos Sanchez-Garibay, Citlaltepetl Salinas Lara and Carlos Penafiel
Article Type: Original Research | First Published: July 11, 2019
Craniopharyngiomas constitute 2 to 4% of intracranial neoplasms. Although this tumors exhibit a benign histopathological pattern, recurrence is commonly reported by cerebrospinal fluid seeding and direct brain invasion. The aim of this study was to analyses and recognizes craniopharyngioma pathological features in relationship to brain invasion as a prognostic factor. One hundred patients who were surgically treated for Craniopharyngiomas extending outside the sellar and suprasellar regions were...
Primary Myxofibrosarcoma of the Breast: Case Report and Review
Raid Jastania and Tahani Nageeti
Article Type: Case Report | First Published: June 17, 2019
Soft tissue sarcomas of the breast are very rare tumors and account for less than 1% of all primary malignant breast tumors. We are reporting a case of primary myxofibrosarcoma of the breast in a 55-year-old woman treated at King Abdulla Medical City and we conducted a literature review on primary soft tissue sarcomas of the breast....
Efficacy of n-Heptane as a Xylene Substitute in Routine Histopathology
Anubhuti Shrivastava, Shreenivas Kallianpur and Sandeep Gupta
Article Type: Research Article | First Published: June 17, 2019
The aim of our study was to evaluate the efficacy of n-Heptane (C7H16) as a xylene substitute for clearing, deparaffinizing and staining procedures in routine histopathology. 30 biopsied oral tissues were divided in two halves, each half was processed by xylene and n-Heptane respectively. Kappa statistical analysis established agreement between observers in all criteria's with significant p value < 0.05. The p value (> 0.05) was not statistically significant with Mann-Whitney U Test, for all cri...
Adult Glioblastoma and the Role of DAXX (Death Domain Associated Protein) Tumor Biomarker
Sean M Hacking, Cao Jin, Seungjun Ahn, Deepika Savant and Mansoor Nasim
Article Type: Retrospective Study | First Published: May 18, 2019
Glioblastoma, also known as glioblastoma multiforme (GBM), is the most aggressive primary brain cancer. GBM comprises 16% of all primary brain neoplasms with an incidence rate of 3.2 per 100,000 people. Patients with GBM have a poor prognosis, less than 5% of them survive for more than 5 years. In the treatment of GBM there is currently insufficient information to improve disease management because conventional treatments universally fail. Currently there is a crucial need to identify relevant t...
Proteinuria Level and Associated Changes in Glomerular Podocytes and Renal Tubular Epithelium
Maha M Arafah
Article Type: Original Research Article | First Published: April 29, 2019
The correlation between glomerular podocytes and renal tubular cells involved in handling of leaked proteins and the level of proteinuria was evaluated. Retrospective 22 cases of clinical proteinuria in patients with various glomerulopathies were retrieved and analyzed. Glomerulopathies in the concerned patients were pathologically diagnosed through light and electron microscopic examination of the submitted renal biopsies. Three cases with protein levels in urine within the acceptable normal ra...
Cellular Desmoplastic or Anaplastic Supratentorial Ependymoma with Neuronal Differentiation in Probable Associated to RELA Fusion? Case Report
Martha Lilia Tena-Suck, Armando Ruiz-Trevino, Laura Chavez-Macias, Carlos Penafiel-Salgado and Carlos Sanchez-Garibay
Article Type: Case Report | First Published: April 20, 2019
Cellular Ependymoma is a term losing in the new WHO 2016 criteria, actually are classified as classical or anaplastic or associated to RELA fusion. We presented a rare case report of classical cellular ependymoma in supratentorial location, which presented a neuronal differentiation and desmoplasia in a young man of 29-yr-old, Immunohistochemistry tumor cells expressed Neu-N, Synaptophysin, SNE, α-synuclein, beta tubulin, ubiquitin, neurofilament, D2DR, and GFAP and vimentin. This rare tumor is...
Predictive Value of Cerebrovascular Reserve in Patients with Carotid Artery Stenosis for Choosing Treatment Strategy
Аliev VA, Semenyutin VB and Panuntsev GK
Article Type: Review Article | First Published: April 08, 2019
The choice of treatment of carotid artery stenosis is firstly based on assessment of the degree of stenosis and embologeneity of the atherosclerotic plaque. But even in "good-risk" population it is still difficult to identify the patients who are particularly at high threat of stroke and would most benefit from carotid reconstruction. Along with common criteria numerous studies also focus on a prognostic role of a cerebrovascular reserve (CVR) and its state which allows to carry out more objecti...
Clinical and Genetics Findings in Mobius Syndrome: Role of Hoxa1 and Hoxb1 Mutations
Lineu Perrone Jr, Felipe Perozzo Daltoe, Luiz Carlos Areas Araujo, Fabio Daumas Nunes, Marina Helena Cury Gallottini and Andrea Mantesso
Article Type: Original Article | First Published: January 14, 2019
Mobius syndrome (MBS) is a rare congenital neurological disorder typically characterized by the absence or underdevelopment of the 6th and 7th cranial nerves, causing a loss of facial expression and strabismus. Other cranial nerves may be affected in addition to other structures such as the jaw, limbs, and anterior chest. While the primary cause of MBS has not yet been identified different hypotheses have been enumerated, including a possible genetic alteration. The Hoxb1 gene may be a good cand...